Issue 10, 2023

Recent advancements in design of nucleic acid nanocarriers for controlled drug delivery

Abstract

Research of nanoscale nucleic acid carriers has garnered attention in recent years due to their distinctive and controllable properties. However, current knowledge is limited in how we can efficiently utilize these systems for clinical applications. Several researchers have pioneered new and innovative nanocarrier drug delivery systems, but understanding physiochemical properties and behavior in vivo is vital to implementing them as clinical drug delivery platforms. In this review, we outline the most significant innovations in the synthesis, physical properties, and utilization of nucleic acid nanocarriers in the past 5 years, addressing the crucial properties which improve nanocarrier characteristics, delivery, and drug release. The challenges of controlling the transport of nucleic acid nanocarriers and therapeutic release for biological applications are outlined. Barriers which inhibit effective transport into tissue are discussed with emphasis on the modifications needed to overcome such obstacles. The novel strategies discussed in this work summarize the pivotal features of modern nucleic nanocarriers and postulate where future developments could revolutionize the translation of these tools into a clinical setting.

Graphical abstract: Recent advancements in design of nucleic acid nanocarriers for controlled drug delivery

Article information

Article type
Review Article
Submitted
25 अक्तूबर 2022
Accepted
06 फरवरी 2023
First published
14 फरवरी 2023

J. Mater. Chem. B, 2023,11, 2078-2094

Recent advancements in design of nucleic acid nanocarriers for controlled drug delivery

R. J. Mosley, B. Rucci and M. E. Byrne, J. Mater. Chem. B, 2023, 11, 2078 DOI: 10.1039/D2TB02325C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements