Issue 1, 2023

Visible light metallaphotoredox catalysis in the late-stage functionalization of pharmaceutically potent compounds

Abstract

The late stage functionalization (LSF) of complex biorelevant chemicals is a valuable approach for accelerating the discovery of structure–activity relationships (SARs) and optimising ADME (absorption, distribution, metabolism, and excretion) profiles. To this end, visible-light metallaphotocatalysis provides a unique opportunity to develop smooth and clean drug functionalization by realising site-specific reactivities under very mild reaction conditions. This study provides a comprehensive evaluation of the current research, highlighting recent advances in the discipline while emphasising predicted future advancements and prospective applications along with visible-light metallaphotocatalytic synthesis methods for the LSF of medicines and pharmaceutically potent compounds that are now accessible.

Graphical abstract: Visible light metallaphotoredox catalysis in the late-stage functionalization of pharmaceutically potent compounds

Article information

Article type
Review Article
Submitted
07 अक्तूबर 2022
Accepted
04 नवम्बर 2022
First published
08 नवम्बर 2022

Org. Chem. Front., 2023,10, 216-236

Visible light metallaphotoredox catalysis in the late-stage functionalization of pharmaceutically potent compounds

P. P. Singh, P. K. Singh and V. Srivastava, Org. Chem. Front., 2023, 10, 216 DOI: 10.1039/D2QO01582J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements