Glycopeptoid nanospheres: glycosylation-induced coacervation of poly(sarcosine)

Yota Okuno; Tomoki Nishimura; Yoshihiro Sasaki; Kazunari Akiyoshi

doi:10.1039/D2NA00218C

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Glycopeptoid nanospheres: glycosylation-induced coacervation of poly(sarcosine)†

Yota Okuno,

^ab Tomoki Nishimura,

^c Yoshihiro Sasaki

^a and Kazunari Akiyoshi*^a

Author affiliations

* Corresponding authors

^a Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Kyoto Daigaku-Katsura, Nishikyo-ku, Kyoto 615-8510, Japan
E-mail: akiyoshi.kazunari.2e@kyoto-u.ac.jp

^b Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35, Yamanote-cho, Suita City, Osaka, Japan

^c Department of Chemistry and Materials, Faculty of Textile Science and Technology, Shinshu University, 3-15-1, Tokida, Nagano 386-8567, Japan

Abstract

Conjugation of maltopentaose to water-soluble homo-poly(sarcosine) induced self-association and formed nanospheres (−150 nm) in water although homo-poly(sarcosine) was water-soluble and did not form any aggregates. Fluorescent probe experiments showed that the spheres were non-ionic glycopeptoid coacervate-like particles with both hydrophobic and hydrophilic domains inside.

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Article information

DOI: https://doi.org/10.1039/D2NA00218C
Article type: Communication
Submitted: 07 अप्रैल 2022
Accepted: 25 जून 2022
First published: 27 जून 2022
This article is Open Access

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Nanoscale Adv., 2022,4, 3707-3710

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Glycopeptoid nanospheres: glycosylation-induced coacervation of poly(sarcosine)

Y. Okuno, T. Nishimura, Y. Sasaki and K. Akiyoshi, Nanoscale Adv., 2022, 4, 3707 DOI: 10.1039/D2NA00218C

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Glycopeptoid nanospheres: glycosylation-induced coacervation of poly(sarcosine)†

Abstract

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Glycopeptoid nanospheres: glycosylation-induced coacervation of poly(sarcosine)

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