Issue 14, 2022

Applications of upconversion nanoparticles in analytical and biomedical sciences: a review

Abstract

Lanthanide-doped upconversion nanoparticles (UCNPs) have gained more attention from researchers due to their unique properties of photon conversion from an excitation/incident wavelength to a more suitable emission wavelength at a designated site, thus improving the scope in the life sciences field. Due to their fascinating and unique optical properties, UCNPs offer attractive opportunities in theranostics for early diagnostics and treatment of deadly diseases such as cancer. Also, several efforts have been made on emerging approaches for the fabrication and surface functionalization of luminescent UCNPs in optical biosensing applications using various infrared excitation wavelengths. In this review, we discussed the recent advancements of UCNP-based analytical chemistry approaches for sensing and theranostics using a 980 nm laser as the excitation source. The key analytical merits of UNCP-integrated fluorescence analytical approaches for assaying a wide variety of target analytes are discussed. We have described the mechanisms of the upconversion (UC) process, and the application of surface-modified UCNPs for in vitro/in vivo bioimaging, photodynamic therapy (PDT), and photothermal therapy (PTT). Based on the latest scientific achievements, the advantages and disadvantages of UCNPs in biomedical and optical applications are also discussed to overcome the shortcomings and to improve the future study directions. This review delivers beneficial practical information of UCNPs in the past few years, and insights into their research in various fields are also discussed precisely.

Graphical abstract: Applications of upconversion nanoparticles in analytical and biomedical sciences: a review

Article information

Article type
Tutorial Review
Submitted
01 दिसम्बर 2021
Accepted
01 जून 2022
First published
02 जून 2022

Analyst, 2022,147, 3155-3179

Applications of upconversion nanoparticles in analytical and biomedical sciences: a review

S. Borse, R. Rafique, Z. V. P. Murthy, T. J. Park and S. K. Kailasa, Analyst, 2022, 147, 3155 DOI: 10.1039/D1AN02170B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements