A halogen bond-donor amino acid for organocatalysis in water†
Greta
Bergamaschi, 
*a
Luisa
Lascialfari,
‡a
Andrea
Pizzi,
a
Maria Isabel
Martinez Espinoza,
a
Nicola
Demitri,
b
Alberto
Milani,
a
Alessandro
Gori
*c
and
Pierangelo
Metrangolo
a
*a
Luisa
Lascialfari,
‡a
Andrea
Pizzi,
a
Maria Isabel
Martinez Espinoza,
a
Nicola
Demitri,
b
Alberto
Milani,
a
Alessandro
Gori
*c
and
Pierangelo
Metrangolo
a
Abstract
Herein we report a halogen bond-donor amino acid, 4-iodotetrafluorophenylalanine, which behaves as a catalyst for the aqueous synthesis of bis-(heterocyclic)methanes. We also provide experimental evidence that halogen bonding is a plausible explanation for the observed catalytic effect.
- This article is part of the themed collection: Fluorine Chemistry
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