Issue 22, 2016

Facile fabrication of amphiphilic AIE active glucan via formation of dynamic bonds: self assembly, stimuli responsiveness and biological imaging

Abstract

Fluorescent organic nanoparticles (FONs) with aggregation induced emission (AIE) properties have recently emerged as one of the most promising luminescent nanomaterials for biomedical applications due to their unique AIE feature. In this study, we reported the preparation of AIE active FONs through mixing AIE dye (TPE-CHO), 3-aminobenzeneboronic acids (ABBA) and glucan in one-pot. ABBA acted as a molecular “bridge” to conjugate TPE-CHO with glucan via formation of a Schiff base and phenyl borate. The resultant products (Glu–TPE FONs) showed amphiphilic properties and could self-assemble into nanoparticles in an aqueous solution. Glu–TPE FONs showed strong luminescence intensity and high water dispersibility because of the AIE properties of TPE-CHO and hydrophilic nature of glucan. To examine the biomedical application potential of glucan–AIE FONs, the responsiveness, biocompatibility and cell uptake behavior of Glu–TPE FONs were subsequently examined. We demonstrated that Glu–TPE FONs possess good biocompatibility and can be potentially used for biological imaging applications. More importantly, it is well known that the Schiff base and phenyl borate can respond to pH and glucose. Therefore, Glu–TPE FONs can be used for the fabrication of multifunctional biomaterials with stimuli responsiveness.

Graphical abstract: Facile fabrication of amphiphilic AIE active glucan via formation of dynamic bonds: self assembly, stimuli responsiveness and biological imaging

Supplementary files

Article information

Article type
Paper
Submitted
27 मार्च 2016
Accepted
03 मई 2016
First published
03 मई 2016

J. Mater. Chem. B, 2016,4, 4033-4039

Facile fabrication of amphiphilic AIE active glucan via formation of dynamic bonds: self assembly, stimuli responsiveness and biological imaging

Q. Wan, M. Liu, D. Xu, H. Huang, L. Mao, G. Zeng, F. Deng, X. Zhang and Y. Wei, J. Mater. Chem. B, 2016, 4, 4033 DOI: 10.1039/C6TB00776G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements