Issue 98, 2016

Synthesis of 3-arylindole derivatives from nitroalkane precursors

Abstract

3-Arylindole derivatives were synthesized by Cu(I) catalysed intramolecular Ullmann coupling of 2-bromoarylaminoalkanes. 2-Bromoarylaminoalkanes were synthesized from 2-bromoarylnitroalkanes, which in turn prepared through AlCl3-mediated Friedel–Crafts alkylation of bromo-substituted β-nitrostyrenes and arenes.

Graphical abstract: Synthesis of 3-arylindole derivatives from nitroalkane precursors

Supplementary files

Article information

Article type
Paper
Submitted
23 अगस्त 2016
Accepted
02 अक्तूबर 2016
First published
03 अक्तूबर 2016

RSC Adv., 2016,6, 96049-96056

Synthesis of 3-arylindole derivatives from nitroalkane precursors

C. Huang, C. Kuo, A. Konala, T. Yang, L. Lin, Y. Chen, V. Kavala and C. Yao, RSC Adv., 2016, 6, 96049 DOI: 10.1039/C6RA21144E

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