Issue 57, 2016

Palladium-catalyzed radical cascade difluoroalkylation/cyclization of acrylamide with ethyl difluorobromoacetate

Abstract

An efficient Pd(0)-catalyzed radical cascade difluoroalkylation/cyclization of acrylamide with ethyl difluorobromoacetate was described. In addition, the reaction can be extended to perfluoroalkyl iodides and bromodifluoromethyl phosphonate. Mechanistic studies demonstrated that a radical addition/cyclization process was involved in the sequences.

Graphical abstract: Palladium-catalyzed radical cascade difluoroalkylation/cyclization of acrylamide with ethyl difluorobromoacetate

Supplementary files

Article information

Article type
Paper
Submitted
04 मार्च 2016
Accepted
20 मई 2016
First published
20 मई 2016

RSC Adv., 2016,6, 51703-51709

Palladium-catalyzed radical cascade difluoroalkylation/cyclization of acrylamide with ethyl difluorobromoacetate

X. Xia, S. Zhu, Y. Li and H. Wang, RSC Adv., 2016, 6, 51703 DOI: 10.1039/C6RA05744F

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