Issue 28, 2016

A cascade reaction for the new and direct synthesis of indolofuroquinoxalines

Abstract

The 7H-indolo[3′,2′:4,5]furo[2,3-b]quinoxaline derivatives are synthesized directly from methyl 2-(2-chloro-1H-indol-3-yl)-2-oxoacetate or its N-alkyl derivatives under neutral or mildly acidic conditions. This new one-pot methodology was found to be general and greener as it avoids the use of environmentally harmful POCl3 and strong alkali required for the previously reported method. It is also amenable for scale-up.

Graphical abstract: A cascade reaction for the new and direct synthesis of indolofuroquinoxalines

Supplementary files

Article information

Article type
Paper
Submitted
07 फरवरी 2016
Accepted
19 फरवरी 2016
First published
22 फरवरी 2016

RSC Adv., 2016,6, 23489-23497

A cascade reaction for the new and direct synthesis of indolofuroquinoxalines

S. P. Nikumbh, A. Raghunadh, T. S. Rao, V. N. Murthy, S. C. Joseph, Y. L. N. Murthy and M. Pal, RSC Adv., 2016, 6, 23489 DOI: 10.1039/C6RA03556F

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