Issue 22, 2013

Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling

Abstract

We herein report on the pharmacophore determination of the ERK docking domain inhibitor (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione, which has led to the discovery of compounds with greater selectivities for inhibiting the proliferation of melanoma cells containing active ERK signaling.

Graphical abstract: Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling

Article information

Article type
Paper
Submitted
30 जनवरी 2013
Accepted
09 अप्रैल 2013
First published
09 अप्रैल 2013

Org. Biomol. Chem., 2013,11, 3706-3732

Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling

K. Jung, R. Samadani, J. Chauhan, K. Nevels, J. L. Yap, J. Zhang, S. Worlikar, M. E. Lanning, L. Chen, M. Ensey, S. Shukla, R. Salmo, G. Heinzl, C. Gordon, T. Dukes, A. D. MacKerell, Jr., P. Shapiro and S. Fletcher, Org. Biomol. Chem., 2013, 11, 3706 DOI: 10.1039/C3OB40199E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements