Issue 31, 2011

Automated solid phase synthesis of teichoic acids

Abstract

This communication describes the first automated solid phase synthesis of teichoic acids (TAs) and the preparation by this method of a number of well-defined TA structures, which were probed for their antigenicity. An opsonophagocytic killing assay revealed a clear TA-length–activity relationship and indicated a promising candidate for future vaccine development.

Graphical abstract: Automated solid phase synthesis of teichoic acids

Supplementary files

Article information

Article type
Communication
Submitted
27 मई 2011
Accepted
27 जून 2011
First published
06 जुलाई 2011

Chem. Commun., 2011,47, 8961-8963

Automated solid phase synthesis of teichoic acids

W. F. J. Hogendorf, N. Meeuwenoord, H. S. Overkleeft, D. V. Filippov, D. Laverde, A. Kropec, J. Huebner, G. A. Van der Marel and J. D. C. Codée, Chem. Commun., 2011, 47, 8961 DOI: 10.1039/C1CC13132J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements