Issue 24, 2024

Role of aptamer technology in extracellular vesicle biology and therapeutic applications

Abstract

Extracellular vesicles (EVs) are cell-derived nanosized membrane-bound vesicles that are important intercellular signalling regulators in local cell-to-cell and distant cell-to-tissue communication. Their inherent capacity to transverse cell membranes and transfer complex bioactive cargo reflective of their cell source, as well as their ability to be modified through various engineering and modification strategies, have attracted significant therapeutic interest. Molecular bioengineering strategies are providing a new frontier for EV-based therapy, including novel mRNA vaccines, antigen cross-presentation and immunotherapy, organ delivery and repair, and cancer immune surveillance and targeted therapeutics. The revolution of EVs, their diversity as biocarriers and their potential to contribute to intercellular communication, is well understood and appreciated but is ultimately dependent on the development of methods and techniques for their isolation, characterization and enhanced targeting. As single-stranded oligonucleotides, aptamers, also known as chemical antibodies, offer significant biological, chemical, economic, and therapeutic advantages in terms of their size, selectivity, versatility, and multifunctional programming. Their integration into the field of EVs has been contributing to the development of isolation, detection, and analysis pipelines associated with bioengineering strategies for nano-meets-molecular biology, thus translating their use for therapeutic and diagnostic utility.

Graphical abstract: Role of aptamer technology in extracellular vesicle biology and therapeutic applications

Article information

Article type
Review Article
Submitted
15 जनवरी 2024
Accepted
06 मई 2024
First published
25 मई 2024

Nanoscale, 2024,16, 11457-11479

Role of aptamer technology in extracellular vesicle biology and therapeutic applications

R. Chowdhury, S. Eslami, C. V. Pham, A. Rai, J. Lin, Y. Hou, D. W. Greening and W. Duan, Nanoscale, 2024, 16, 11457 DOI: 10.1039/D4NR00207E

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