Issue 41, 2017

Multilayered upconversion nanocomposites with dual photosensitizing functions for enhanced photodynamic therapy

Abstract

The energy transfer from upconversion nanoparticles (UCNPs) to photosensitizers has been widely used for generating reactive oxygen species (ROS) in photodynamic therapy (PDT) by near infrared (NIR) excitation. However, the poor spectral overlap of lanthanide ions and conventional photosensitizers leads to low PDT efficiency. In this study, we construct a multilayered upconversion nanoplatform with dual photosensitizers to efficiently use the UV and visible upconversion emissions in NIR-responsive PDT. The nanoplatform consists of three functional layers, which are the upconversion nanoparticle as a core, and light-sensitive conjugated polymer and apo-transferrin-titanocene (Tf@Tc) as shells. Under NIR irradiation, apparent energy transfer occurs from the core to the polymer and Tc components in the shell, producing reactive oxygen species and free radicals for cancer cell killing. In vitro cellular assays show the synergistic therapeutic effect of the conjugated polymer and Tc as photosensitizers. In vivo animal studies show that tumor growth is significantly inhibited in the mice receiving the theranostic platform and NIR irradiation. Based on these observations, the multilayered upconversion nanocomposites can find potential applications in NIR-mediated anti-tumor therapy.

Graphical abstract: Multilayered upconversion nanocomposites with dual photosensitizing functions for enhanced photodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
21 जुलाई 2017
Accepted
21 सितम्बर 2017
First published
25 सितम्बर 2017

J. Mater. Chem. B, 2017,5, 8169-8177

Multilayered upconversion nanocomposites with dual photosensitizing functions for enhanced photodynamic therapy

S. Liu, Y. Yuan, Y. Yang, Z. Liu, S. Yin, W. Qin and C. Wu, J. Mater. Chem. B, 2017, 5, 8169 DOI: 10.1039/C7TB01968H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements