Multicavity macrocyclic hosts

Abstract

Multicavity macrocyclic hosts are host molecules comprising more than one macrocyclic guest binding components connected through multipoint linkages. Macrocycles, such as crown ethers, pillar[n]arenes, calix[n]arenes, and calix[4]pyrroles, have been used to fabricate multicavity hosts, either homotopic or heterotopic. This review is mainly focused on the molecular structures and host–guest behaviors of multicavity macrocyclic host molecules and their applications in the assembly of sophisticated supramolecular architectures.