This review provides an overview on recent developments in transition-metal-catalysed intermolecular saturated C(sp3)–N(sp3) bond-forming reactions. Moreover, limitations and perspectives on emerging opportunities in this area are also discussed.
Catalytic insertion of nitrenes into B–H bonds produces unique compounds with chiral boron atoms.
The three-component reaction of the diazo compound, azide and allylboronate for preparation of homoallylic amine derivatives was explored, and Rh2(esp)2 was utilized as the optimal catalyst.
Dirhodium-catalyzed transformations, not limited to carbene and nitrene transfer reactions, are reviewed, including cycloisomerization, hetero-Diels–Alder (HDA) reactions, ene reactions, arylation, radical oxidation reactions and C–H activation, etc.
Dirhodium tetracarboxylate complexes catalyze a number of useful carbenoid transformations including cyclopropanation and C–H functionalization.