Novel pyrazolo[3,4-d]pyrimidine derivatives: design, synthesis, anticancer evaluation, VEGFR-2 inhibition, and antiangiogenic activity

Ahmed M. Abdelhamed, Rasha A. Hassan, Hanan H. Kadry and Amira A. Helwa

RSC Med. Chem., 2023, 14, 2640
DOI: 10.1039/D3MD00476G

Coumarin as an Elite Scaffold in Anti-Breast Cancer Drug Development: Design Strategies, Mechanistic Insights, and Structure–Activity Relationships

Atamjit Singh, Karanvir Singh, Kamaljit Kaur, Amandeep Singh, Aman Sharma, Kirandeep Kaur, Jaskirat Kaur, Gurleen Kaur, Uttam Kaur, Harsimran Kaur, Prabhsimran Singh and Preet Mohinder Singh Bedi

Biomedicines, 2024, 12, 1192
DOI: 10.3390/biomedicines12061192

Novel Pyrimidine-5-Carbonitriles as potential apoptotic and antiproliferative agents by dual inhibition of EGFRWT/T790M and PI3k enzymes; Design, Synthesis, biological Evaluation, and docking studies

Nada Reda, Khaled O. Mohamed, Kareem Abdou, Amira A. Helwa and Ahmed Elshewy

Bioorganic Chemistry, 2024, 145, 107185
DOI: 10.1016/j.bioorg.2024.107185

Design, synthesis, and in-silico studies of hydrazide-hydrazone linked coumarin glycoconjugates with possible antiproliferative activity

Ravendra Kumar, Deepanshi Chauhan, Vinay Kumar Singh, Ambuj Kumar Kushwaha and Divya Kushwaha

Carbohydrate Research, 2025, 556, 109620
DOI: 10.1016/j.carres.2025.109620

Electrochemical Synthesis of Versatile Pyrimidine and Oxadiazoles Tethered Triazoles as Inhibitors of VEGFR-2 in Human Breast Cancer Cells

Akshay Ravish, Tejaswini P. Siddappa, Zhang Xi, Divakar Vishwanath, Arunkumar Mohan, Shreeja Basappa, Niranjan Pattehalli Krishnamurthy, Peter E. Lobie, Vijay Pandey and Basappa Basappa

Catalysts, 2023, 13, 1353
DOI: 10.3390/catal13101353

Development of certain benzylidene coumarin derivatives as anti-prostate cancer agents targeting EGFR and PI3Kβ kinases

Lina M. A. Abdel Ghany, Tarek S. Ibrahim, Abdulrahman S. Alharbi, Mohamed S. Abdel-Aziz, Eman M. El-labbad, Mohamed Elagawany and Noha Ryad

Journal of Enzyme Inhibition and Medicinal Chemistry, 2024, 39
DOI: 10.1080/14756366.2024.2311157

One-Pot quaternization strategy for novel Poly(pyridinium-acetamide) ionic polymers as potential anticancer and anti-microbial agents

Salsabeel Al-Sodies, Mahmoud A. Hussein, Abdullah M. Asiri, Mohamed S. Nafie, Mohamed Reda Aouad, Nadjet Rezki, Kareem T. Abul-Nasr, Maha A. Alshubramy and Abrar S. Alnafisah

European Polymer Journal, 2025, 225, 113729
DOI: 10.1016/j.eurpolymj.2025.113729

Multi-target Triazole–Benzopyrone hybrids modulating cholinergic dysfunction, oxidative stress, and neuroinflammation through GFAP/NF-κB/APOE/NLRP3 axis in Alzheimer's disease

Omar K. El-Mokaddem, Ghada F. Elmasry, Abeer Salama, Heba M. Mansour, Walaa R. Mahmoud and Lina M.A. Abdel Ghany

European Journal of Medicinal Chemistry, 2026, 315, 118949
DOI: 10.1016/j.ejmech.2026.118949

Modulation of Human Colon Cell Activity by Synthetic Coumarin Derivatives Bearing a Phosphonate Group

Katarzyna Szwaczko, Roman Paduch, Kamil Dziuba, Krzysztof Szafrański and Adrian Wiater

Molecules, 2025, 30, 2846
DOI: 10.3390/molecules30132846

Design, Synthesis, and 2D QSAR Analysis of Some Novel Pyrazolo[1,5‐a]pyrimidine Derivatives as Pim‐1 Kinase Inhibitors for the Treatment of MCF‐7 Breast Cancer

Esraa Z. Mohammed, Nehad M. El‐Dydamony, Ahmed B. M. Mehany, Samar H. Fahim, Hatem A. Abdel Aziz and Noha M. Ibrahim

Drug Development Research, 2025, 86
DOI: 10.1002/ddr.70168

Facile Synthesis of Some Coumarin Derivatives and Their Cytotoxicity through VEGFR2 and Topoisomerase II Inhibition

Mohamed S. Gomaa, Ibrahim A. I. Ali, Gaber El Enany, El Sayed H. El Ashry, Samir M. El Rayes, Walid Fathalla, Abdulghany H. A. Ahmed, Samar A. Abubshait, Haya A. Abubshait and Mohamed S. Nafie

Molecules, 2022, 27, 8279
DOI: 10.3390/molecules27238279

Novel 3-phenylquinazolin-2,4(1H,3H)-diones as dual VEGFR-2/c-Met-TK inhibitors: design, synthesis, and biological evaluation

Abdelfattah Hassan, Ahmed M. Mosallam, Amal O. A. Ibrahim, Mohamed Badr and Aboubakr H. Abdelmonsef

Sci Rep, 2023, 13
DOI: 10.1038/s41598-023-45687-y

Dual Anticancer and COX‐2 Inhibitory Activity of Tailored Paracetamol‐Alkanesulfonate Conjugates: A Promising Therapeutic Approach

Asmaa F. Kassem, Marwa M. Mounier, Mostafa I. Abdelglil, Sameh Abdelwahed, Ahmed A. El‐Rashedy, Asmaa Saleh, Mahmoud G. A. Saleh and Aladdin M. Srour

Archiv der Pharmazie, 2025, 358
DOI: 10.1002/ardp.70125

Comparison between conventional, grinding, and microwave synthesis of methylpyrazoles as VEGFR-2/HSP90 dual inhibitors

Ebtehal M. Husseiny, Rana M. Abdelnaby, Najla Altwaijry, Asmaa Saleh and Kurls E. Anwer

Future Medicinal Chemistry, 2025, 17, 899
DOI: 10.1080/17568919.2025.2485866

Identification of novel thiazolyl-1,2,3-triazole hybrids as potent VEGFR-2 inhibitors for breast cancer treatment

Aya M. Almatary, Mohamed S.H. Salem, Mohamed R. Elnagar, Nahed Nasser Eid El-Sayed, Magda A.-A. El-Sayed, Mohammad M Al-Sanea, Abdelrahman Hamdi, Tarek S. Ibrahim and Mohamed H. Aboutaleb

Journal of Molecular Structure, 2026, 1357, 145203
DOI: 10.1016/j.molstruc.2025.145203