Issue 43, 2023

An efficient metal-free desulfurization strategy promoted by Togni-II reagent

Abstract

Desulfurization is a versatile synthetic tool in organic synthesis, particularly in peptide chemistry, where it offers an effective conversion strategy for compounds that contain mercaptan groups. In this study, we present a metal-free desulfurization method for amino acids and peptides using a Togni-II reagent as a radical initiator. Our method showed excellent efficiency and extensive substrate tolerance, circumventing the formation of radical adducts caused by VA-044. The obtained results further expand the applicability of Togni-II reagent as a key promotor in radical-based reactions.

Graphical abstract: An efficient metal-free desulfurization strategy promoted by Togni-II reagent

Supplementary files

Article information

Article type
Communication
Submitted
29 מרץ 2023
Accepted
27 אפר 2023
First published
27 אפר 2023

Chem. Commun., 2023,59, 6513-6516

An efficient metal-free desulfurization strategy promoted by Togni-II reagent

J. Zhang, H. Liu, S. Teng, Z. Liao, L. Meng, Q. Wan and S. Dong, Chem. Commun., 2023, 59, 6513 DOI: 10.1039/D3CC00983A

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