Issue 8, 2018

Porous gold nanocluster-decorated manganese monoxide nanocomposites for microenvironment-activatable MR/photoacoustic/CT tumor imaging

Abstract

Stimuli-responsive nanoprobes that integrate multi-modal imaging capacities are highly desirable for precise tumor visualization. Herein, novel porous gold nanocluster-decorated manganese monoxide nanocomposites (MnO@Au NCs) were synthesized via a facile approach. The porous gold nanocluster layer was germinated on the surface of the as-prepared MnO@DMSA NPs through simple reduction of chloroauric acid in the presence of hydroxylamine hydrochloride. The MnO@Au NCs could be effectively internalized by tumor cells and slowly release Mn2+ ions within the acidic tumor microenvironment, improving the visualization of the tumor morphology. Benefitting from the porous architecture, the enhanced accessibility of Mn centers to proximal water molecules greatly augmented T1-weighted MRI contrast capacity. Compared with the conventional Mn-based contrast agents, the porous Au nanoclusters on MnO@Au NCs could delay the release of Mn2+ ions and thus effectively prolong the diagnostic time window. The broad near-infrared absorption of MnO@Au NCs features a high photoacoustic imaging depth than that of conventional gold nanospheres. Moreover, the Au nanoclusters exhibited desirable X-ray computed tomography contrast and rapid clearance from the living body. The as-prepared MnO@Au NCs hold great potential for accurate tumor imaging.

Graphical abstract: Porous gold nanocluster-decorated manganese monoxide nanocomposites for microenvironment-activatable MR/photoacoustic/CT tumor imaging

Supplementary files

Article information

Article type
Communication
Submitted
15 נוב 2017
Accepted
06 ינו 2018
First published
09 ינו 2018

Nanoscale, 2018,10, 3631-3638

Porous gold nanocluster-decorated manganese monoxide nanocomposites for microenvironment-activatable MR/photoacoustic/CT tumor imaging

Y. Liu, X. Lv, H. Liu, Z. Zhou, J. Huang, S. Lei, S. Cai, Z. Chen, Y. Guo, Z. Chen, X. Zhou and L. Nie, Nanoscale, 2018, 10, 3631 DOI: 10.1039/C7NR08535D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements