Amorphous metal–organic frameworks for drug delivery

Claudia Orellana-Tavra; Emma F. Baxter; Tian Tian; Thomas D. Bennett; Nigel K. H. Slater; Anthony K. Cheetham; David Fairen-Jimenez

doi:10.1039/C5CC05237H

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Amorphous metal–organic frameworks for drug delivery†

Claudia Orellana-Tavra,^a Emma F. Baxter,^b Tian Tian,^a Thomas D. Bennett,^b Nigel K. H. Slater,^a Anthony K. Cheetham^b and David Fairen-Jimenez

*^a

Author affiliations

* Corresponding authors

^a Department of Chemical Engineering & Biotechnology, University of Cambridge, CB2 3RA Cambridge, UK
E-mail: df334@cam.ac.uk

^b Department of Materials Science and Metallurgy, University of Cambridge, CB3 0FS Cambridge, UK

Abstract

We report the encapsulation of the hydrophilic model molecule calcein in the Zr-based MOF UiO-66, followed by amorphization of the framework by ball-milling. We show controlled release of calcein over more than 30 days, compared with the 2 day release period from crystalline UiO-66.

This article is part of the themed collections: Celebrating the 2017 RSC Prize and Award Winners and In celebration of Tony Cheetham’s 70th birthday

Download options Please wait...

Supplementary files

Supplementary information PDF (676K)

Article information

DOI: https://doi.org/10.1039/C5CC05237H
Article type: Communication
Submitted: 25 יונ 2015
Accepted: 21 יול 2015
First published: 21 יול 2015

Download Citation

Chem. Commun., 2015,51, 13878-13881

Author version available

Download author version (PDF)

Permissions

Request permissions

Amorphous metal–organic frameworks for drug delivery

C. Orellana-Tavra, E. F. Baxter, T. Tian, T. D. Bennett, N. K. H. Slater, A. K. Cheetham and D. Fairen-Jimenez, Chem. Commun., 2015, 51, 13878 DOI: 10.1039/C5CC05237H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Amorphous metal–organic frameworks for drug delivery†

Abstract

Supplementary files

Article information

Download Citation

Author version available

Permissions

Amorphous metal–organic frameworks for drug delivery

Social activity

Search articles by author

Spotlight

Advertisements