Ru(ii)-catalysed, inherent-directing-group-enabled site-selective C–H vinyl trifluoromethylation of isoquinolones and benzamides

Abstract

Herein, we unveil an efficient and site-selective Ru(II)-catalysed route for synthesizing vinyltrifluoromethylated arenes by utilising amide carbonyl as an inherent directing group. 2-Bromo-3,3,3-trifluoropropene has been utilised as a sustainable surrogate of vinyltrifluoromethylation to provide diversely decorated isoquinolones and benzamides. Mechanistic studies have been performed to articulate the plausible mechanism. A vast array of substrates is amenable to this transformation, and post-synthetic modification of the products demonstrates the importance of the developed approach.