In situ setup for screening of drug permeation by NMR spectroscopy

Malte Mildner; Simon Hanio; Sebastian Endres; Lena Scheller; Bettina Engel; Laura Castañar; Lorenz Meinel; Ann-Christin Pöppler

doi:10.1039/D3AY01995K

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

In situ setup for screening of drug permeation by NMR spectroscopy†

Malte Mildner,‡^a Simon Hanio,

‡^b Sebastian Endres,^a Lena Scheller,

^b Bettina Engel,^b Laura Castañar,

^c Lorenz Meinel

^b and Ann-Christin Pöppler

*^a

Author affiliations

* Corresponding authors

^a Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany
E-mail: ann-christin.poeppler@uni-wuerzburg.de

^b Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany

^c Department of Organic Chemistry, Faculty of Chemical Science, Complutense University of Madrid, Madrid, Spain

Abstract

There are various commercially available setups for studying drug permeation, which differ in cost and manual labor. We explore an artificial membrane in an NMR tube to assess drug permeation with automated measurements. NMR-based concentrations were validated with HPLC and compared to a conventional setup. Setup-specific challenges and workarounds as well as future setup-designs for this and other applications are discussed.

This article is part of the themed collection: Analytical Methods HOT Articles 2024

Download options Please wait...

Supplementary files

Supplementary information PDF (1142K)

Article information

DOI: https://doi.org/10.1039/D3AY01995K
Article type: Communication
Submitted: 11 נוב 2023
Accepted: 30 דצמ 2023
First published: 08 ינו 2024

Download Citation

Anal. Methods, 2024,16, 1468-1472

Permissions

Request permissions

In situ setup for screening of drug permeation by NMR spectroscopy

M. Mildner, S. Hanio, S. Endres, L. Scheller, B. Engel, L. Castañar, L. Meinel and A. Pöppler, Anal. Methods, 2024, 16, 1468 DOI: 10.1039/D3AY01995K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Analytical Methods

In situ setup for screening of drug permeation by NMR spectroscopy†

Abstract

Supplementary files

Article information

Download Citation

Permissions

In situ setup for screening of drug permeation by NMR spectroscopy

Social activity

Search articles by author

Spotlight

Advertisements