Issue 38, 2023

Iron-chelated semiconducting oligomer nanoparticles for NIR-II fluorescence imaging-guided enhanced chemodynamic/photothermal combination therapy

Abstract

Chemodynamic therapy (CDT) has attracted increasing attention owing to its high tumor specificity and low number of side effects. However, the low absolute concentration of reactive oxygen species (ROS) within tumor cells restricts the CDT efficacy. Herein, we use dihydroartemisinin (DHA) to enhance the CDT efficacy and combine photothermal therapy (PTT) to further improve the anticancer effect. To achieve such a goal, an iron-containing semiconducting oligomer nanoparticle (DHA@FePSOD) is prepared by loading DHA into a Fe3+-chelated NIR-II fluorescent semiconducting oligomer (FePSOD). The Fe3+ ion within DHA@FePSOD can be reduced to the Fe2+ ion by glutathione (GSH) and subsequently catalyze the decomposition of hydrogen peroxide (H2O2) into the highly toxic hydroxyl radical (˙OH) for CDT. The loaded DHA may be further reduced by Fe2+ and generate a DHA radical to enhance the CDT efficacy. In addition, DHA@FePSOD shows a good photothermal effect and intense NIR-II fluorescence signal under 808 nm laser irradiation. Both in vitro and in vivo studies prove the better anticancer effect of DHA@FePSOD than FePSOD, which is attributed to the loaded DHA. Furthermore, DHA@FePSOD can effectively accumulate into a tumor and delineate the tumor via NIR-II fluorescence imaging. This study thus provides an efficient approach for developing a NIR-II fluorescence imaging-guided enhanced chemodynamic/photothermal combination therapeutic nanoplatform.

Graphical abstract: Iron-chelated semiconducting oligomer nanoparticles for NIR-II fluorescence imaging-guided enhanced chemodynamic/photothermal combination therapy

  • This article is part of the themed collection: #MyFirstJMCB

Supplementary files

Article information

Article type
Paper
Submitted
07 יונ 2023
Accepted
01 ספט 2023
First published
01 ספט 2023

J. Mater. Chem. B, 2023,11, 9290-9299

Iron-chelated semiconducting oligomer nanoparticles for NIR-II fluorescence imaging-guided enhanced chemodynamic/photothermal combination therapy

S. Diao, W. Shi, Y. Liu, T. Liang, Z. Xu, W. Zhou, C. Xie and Q. Fan, J. Mater. Chem. B, 2023, 11, 9290 DOI: 10.1039/D3TB01305G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements