Issue 36, 2023

Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation

Abstract

Methyltransferases provide excellent specificity in late-stage alkylation of biomolecules. Their dependence on S-adenosyl-L-methionine (SAM) mandates efficient access to SAM analogues for biocatalytic applications. We directly compared halide methyltransferase (HMT) and methionine adenosyltransferase (MAT) to access SAM analogues and explored their utility in cascade reactions with NovO for regioselective, late-stage Friedel-Crafts alkylation of a coumarin. The HMT cascade efficiently provided SAM for methylation, while the MAT cascade also supplied high levels of SAM analogues for alkylation reactions.

Graphical abstract: Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation

Supplementary files

Article information

Article type
Communication
Submitted
01 מרץ 2023
Accepted
13 אפר 2023
First published
13 אפר 2023

Chem. Commun., 2023,59, 5463-5466

Comparative S-adenosyl-L-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation

A. Hoffmann, K. H. Schülke, S. C. Hammer, A. Rentmeister and N. V. Cornelissen, Chem. Commun., 2023, 59, 5463 DOI: 10.1039/D3CC01036H

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