Issue 19, 2022

Natural product total synthesis using rearrangement reactions

Abstract

Total synthesis of natural products has been an important pursuit in chemical synthesis due to their fascinating structural complexity and/or interesting biological activities. In most synthetic designs, the rapid construction of the core skeletons, the precise control of stereochemistry, and the identification of suitable synthons are key concerns, which, to a large extent, account for the overall synthetic efficiency. This review will highlight how rearrangement reactions can contribute in addressing these three concerns, thus simplifying the total synthesis campaigns.

Graphical abstract: Natural product total synthesis using rearrangement reactions

Article information

Article type
Review Article
Submitted
01 יול 2022
Accepted
05 אוג 2022
First published
06 אוג 2022

Org. Chem. Front., 2022,9, 5383-5394

Natural product total synthesis using rearrangement reactions

L. Chen, G. Li and L. Zu, Org. Chem. Front., 2022, 9, 5383 DOI: 10.1039/D2QO01040B

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