Issue 11, 2020

Ionophore-based pH independent detection of ions utilizing aggregation-induced effects

Abstract

Ionophores have been integrated into various electrochemical and optical sensing platforms for the selective detection of ions. Previous ionophore-based optical sensors rely on a H+ chromoionophore as the signal transducer and consequently, suffered from a pH cross-response. pH independent methods were proposed very recently by utilizing the solvatochromic dyes or the exhaustive mode. Here, we report a pH independent sensing principle based on nanospheres containing ionophores. As the ion-exchange occurs, the signal transducer undergoes aggregation-induced emission (AIE) or aggregation-caused quenching (ACQ), leading to a dramatic change in fluorescence intensity. The principle was evaluated on different ionophores including those selective for K+, Na+, Ca2+, and Pb2+. The nanospheres were also introduced into microfluidic chips and successfully applied for the determination of sodium and potassium ion concentrations in diluted blood serum and urine samples.

Graphical abstract: Ionophore-based pH independent detection of ions utilizing aggregation-induced effects

Supplementary files

Article information

Article type
Paper
Submitted
11 מרץ 2020
Accepted
07 אפר 2020
First published
07 אפר 2020

Analyst, 2020,145, 3846-3850

Ionophore-based pH independent detection of ions utilizing aggregation-induced effects

R. Wang, X. Du, X. Ma, J. Zhai and X. Xie, Analyst, 2020, 145, 3846 DOI: 10.1039/D0AN00486C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements