Issue 8, 2018

Switching off the interactions between graphene oxide and doxorubicin using vitamin C: combining simplicity and efficiency in drug delivery

Abstract

Well-controlled, low-toxicity and highly efficient delivery systems for anticancer drugs are a key challenge for the development of a new class of nanocarrier systems for cancer chemotherapy. Graphene oxide (GO) has been developed to be a nanocarrier of anti-cancer drugs due to its large surface area and biocompatibility; however, understanding of the interface chemistry is very limited. In this work, we report efficient loading and controlled release of doxorubicin (DOX) using the tunable surface of GO. A deep understanding of the surface chemistry between GO and DOX is achieved using spectroscopies and atomic force microscopy. Hydrogen bonding and π–π stacking are confirmed to be the non-covalent interactions between the drugs and the carriers. As a result, improvement of DOX delivery from the GO surface can be achieved using vitamin C.

Graphical abstract: Switching off the interactions between graphene oxide and doxorubicin using vitamin C: combining simplicity and efficiency in drug delivery

Supplementary files

Article information

Article type
Paper
Submitted
26 נוב 2017
Accepted
20 ינו 2018
First published
22 ינו 2018

J. Mater. Chem. B, 2018,6, 1251-1259

Switching off the interactions between graphene oxide and doxorubicin using vitamin C: combining simplicity and efficiency in drug delivery

Z. Liu, J. Liu, T. Wang, Q. Li, P. S. Francis, C. J. Barrow, W. Duan and W. Yang, J. Mater. Chem. B, 2018, 6, 1251 DOI: 10.1039/C7TB03063K

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