Issue 34, 2018

Multimodal Prussian blue analogs as contrast agents for X-ray computed tomography

Abstract

Prussian blue analogs (PBAs) are versatile materials with a wide range of applications. Due to their tunability, intrinsic biocompatibility, as well as low toxicity, these nanoscale coordination polymers have been successfully studied as multimodal contrast agents for multiple imaging techniques. Herein, we report the expanded biomedical application of PBAs to X-ray computed tomography (CT). In our systematic study of the series A{MnII[FeIII(CN)6]} (A = K+, Rb+, Cs+), we showed that derivatives incorporating Rb+ and Cs+ ions in the tetrahedral sites of the parent face-centered cubic cyano-bridged networks exhibited substantially increased X-ray attenuation coefficients, thus yielding significant contrast compared to the clinically approved X-ray contrast agent iohexol at the same concentrations. Additionally, our μ-CT studies revealed that these PBAs could be useful as dual-energy CT contrast agents for different biological specimens by using the lower varying scanning X-ray tube voltages. Finally, in vitro studies using U87-Luc cells treated with PBAs, including cellular CT imaging and bioluminescence cell viability assays, revealed that PBAs were taken up by the glioblastoma cells, with moderate biocompatibility at concentrations below the mM range.

Graphical abstract: Multimodal Prussian blue analogs as contrast agents for X-ray computed tomography

Supplementary files

Article information

Article type
Paper
Submitted
27 אפר 2018
Accepted
16 יול 2018
First published
17 יול 2018

Dalton Trans., 2018,47, 11960-11967

Multimodal Prussian blue analogs as contrast agents for X-ray computed tomography

P. Promdet, B. Rodríguez-García, A. Henry, C. Nguyen, T. Khuu, J. Galan-Mascaros and K. Sorasaenee, Dalton Trans., 2018, 47, 11960 DOI: 10.1039/C8DT01687A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements