Issue 31, 2018

Copper-mediated regioselective C–H etherification of naphthylamides with arylboronic acids using water as an oxygen source

Abstract

The copper-mediated regioselective C–H activation and C–O bond formation of naphthylamides with arylboronic acids has been developed using water as an oxygen source. The kinetic isotope study suggests that C–H bond activation is the rate-determining step. The H2O18 labelling experiment reveals the incorporation of oxygen from water. The substrate scope, functional group diversity and post synthetic utilities are the important practical features.

Graphical abstract: Copper-mediated regioselective C–H etherification of naphthylamides with arylboronic acids using water as an oxygen source

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
17 מרץ 2018
Accepted
25 מרץ 2018
First published
26 מרץ 2018

Chem. Commun., 2018,54, 3899-3902

Copper-mediated regioselective C–H etherification of naphthylamides with arylboronic acids using water as an oxygen source

S. Roy, S. Pradhan and T. Punniyamurthy, Chem. Commun., 2018, 54, 3899 DOI: 10.1039/C8CC02158A

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