Issue 32, 2016

Fortified interpenetrating polymers – bacteria resistant coatings for medical devices

Abstract

Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical device-associated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-bound Klebsiella pneumoniae and methicillin resistant Staphylococcus aureus.

Graphical abstract: Fortified interpenetrating polymers – bacteria resistant coatings for medical devices

Supplementary files

Article information

Article type
Paper
Submitted
04 מאי 2016
Accepted
15 יול 2016
First published
18 יול 2016
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2016,4, 5405-5411

Fortified interpenetrating polymers – bacteria resistant coatings for medical devices

S. Venkateswaran, O. D. Henrique Dos Santos, E. Scholefield, A. Lilienkampf, P. J. Gwynne, D. G. Swann, K. Dhaliwal, M. P. Gallagher and M. Bradley, J. Mater. Chem. B, 2016, 4, 5405 DOI: 10.1039/C6TB01110A

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