Issue 23, 2016

Homochiral crystal generation via sequential dehydration and Viedma ripening

Abstract

1,2-Bis(N-benzoyl-N-methylamino)benzene (2) forms centrosymmetric hydrate crystals (2·xH2O) and non-centrosymmetric anhydrous crystals. Dehydration of this hydrate (30 min at 140 °C) resulted in the formation of chiral crystals (i.e. a physical racemate of the conglomerate crystals) as verified using solid-state circular dichroism and powder X-ray diffraction. Subsequent attrition-enhanced deracemization, also known as Viedma ripening, was used to obtain homochiral crystals of 2 within 5 h.

Graphical abstract: Homochiral crystal generation via sequential dehydration and Viedma ripening

Supplementary files

Article information

Article type
Communication
Submitted
16 ינו 2016
Accepted
16 מרץ 2016
First published
16 מרץ 2016

CrystEngComm, 2016,18, 4277-4280

Homochiral crystal generation via sequential dehydration and Viedma ripening

R. Sivakumar, M. S. Askari, S. Woo, C. Madwar, X. Ottenwaelder, D. S. Bohle and L. A. Cuccia, CrystEngComm, 2016, 18, 4277 DOI: 10.1039/C6CE00119J

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