Issue 4, 2011

C–H functionalization logic in total synthesis

Abstract

In this critical review, the strategic and economic benefits of C–H functionalization logic will be analyzed through the critical lens of total synthesis. In order to illustrate the dramatically simplifying effects this type of logic can potentially have on synthetic planning, we take the reader through a series of case studies in which it has already been successfully applied. In the first section, a chronological look at key historical syntheses will be examined, leading into modern day examples. In the second section, our own experience with applying and executing synthesis with a C–H functionalization “mindset” will be discussed (114 references).

Graphical abstract: C–H functionalization logic in total synthesis

Article information

Article type
Critical Review
Submitted
15 נוב 2010
First published
07 פבר 2011

Chem. Soc. Rev., 2011,40, 1976-1991

C–H functionalization logic in total synthesis

W. R. Gutekunst and P. S. Baran, Chem. Soc. Rev., 2011, 40, 1976 DOI: 10.1039/C0CS00182A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements