Issue 13, 2024

Fabrication of an all-in-one self-enhanced solid-state electrochemiluminescence sensing platform for the selective detection of spermine

Abstract

The fabrication of an all-in-one solid-state ECL sensing platform is beneficial not only for expediting the miniaturization of sensing devices, but also, more importantly, for enabling point-of-care applications. In the present work, a self-enhanced solid-state ECL sensing platform is fabricated using newly synthesised silica polyethylene nanoparticles (SiO2-PEI NPs) which generate a co-reactant in situ and easily self-assemble with Ru(bpy)32+ and shows selective and sensitive detection of spermine at physiological pH (7.4). Spermine induces the maximum ECL emission intensity compared to other biogenic amines due to the presence of two secondary amines. A possible ECL reaction mechanism has been proposed based on CV and ECL experiments, DFT calculations, and in situ ECL spectrum analysis. The developed solid-state sensor showed a linear increase in ECL intensity with increasing spermine concentration in the range of 10 nM to 100 nM with an LOD of 12.2 nM. Compared to other biogenic amines in previous works, chemically synthesised SiO2-PEI NPs used in the present study act as an effective label- and enzyme-free sensor, and the new method is observed to be simple and cost-effective, to overcome various limitations of solution-phase ECL and to avoid the usage of any noble metals.

Graphical abstract: Fabrication of an all-in-one self-enhanced solid-state electrochemiluminescence sensing platform for the selective detection of spermine

Supplementary files

Article information

Article type
Paper
Submitted
05 מרץ 2024
Accepted
08 מאי 2024
First published
08 מאי 2024

Analyst, 2024,149, 3555-3563

Fabrication of an all-in-one self-enhanced solid-state electrochemiluminescence sensing platform for the selective detection of spermine

M. Sornambigai, A. S. Roselin Pavithra, S. Hansda and S. Senthil Kumar, Analyst, 2024, 149, 3555 DOI: 10.1039/D4AN00357H

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