Issue 5, 2024

Recent advances of nanopore technique in single cell analysis

Abstract

Single cells and their dynamic behavior are closely related to biological research. Monitoring their dynamic behavior is of great significance for disease prevention. How to achieve rapid and non-destructive monitoring of single cells is a major issue that needs to be solved urgently. As an emerging technology, nanopores have been proven to enable non-destructive and label-free detection of single cells. The structural properties of nanopores enable a high degree of sensitivity and accuracy during analysis. In this article, we summarize and classify the different types of solid-state nanopores that can be used for single-cell detection and illustrate their specific applications depending on the size of the analyte. In addition, their research progress in material transport and microenvironment monitoring is also highlighted. Finally, a brief summary of existing research challenges and future trends in nanopore single-cell analysis is tentatively provided.

Graphical abstract: Recent advances of nanopore technique in single cell analysis

Article information

Article type
Critical Review
Submitted
14 נוב 2023
Accepted
18 ינו 2024
First published
05 פבר 2024

Analyst, 2024,149, 1350-1363

Recent advances of nanopore technique in single cell analysis

X. Zhang, Z. Su, Y. Zhao, D. Wu, Y. Wu and G. Li, Analyst, 2024, 149, 1350 DOI: 10.1039/D3AN01973J

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