Issue 37, 2023

Dual enzyme-mimicking carbon dots for enhanced antibacterial activity

Abstract

Carbon dot (CD)-based nanozymes have great potential in antibacterial applications. In order to achieve enhanced broad-spectrum antibacterial capacity, we synthesized Co-doped drug-based CDs (Co-Lvx-CDs) using levofloxacin and vitamin B12 as precursors by mimicking the catalysis of antibacterial activity of natural enzymes. The Co-Lvx-CDs retained not only the effective functional groups of the traditional antibiotic levofloxacin but also achieved oxidase-like and peroxidase-like activities to generate reactive oxygen species (ROS) through Co doping. Additionally, the Co-Lvx-CDs had superb fluorescence properties and could be applied in information encryption. The CDs were validated to have a broad-spectrum bactericidal effect against Gram-positive and -negative bacteria, compensating for the limitations of levofloxacin while also having enhanced sterilization ability. Importantly, the proposed Co-Lvx-CDs provide a new idea for the design of multifunctional CD-based nanozymes with preconceived outcomes.

Graphical abstract: Dual enzyme-mimicking carbon dots for enhanced antibacterial activity

Supplementary files

Article information

Article type
Paper
Submitted
17 יונ 2023
Accepted
25 יול 2023
First published
26 יול 2023

J. Mater. Chem. B, 2023,11, 8916-8925

Dual enzyme-mimicking carbon dots for enhanced antibacterial activity

G. Niu, F. Gao, C. Li, Y. Wang, H. Li and Y. Jiang, J. Mater. Chem. B, 2023, 11, 8916 DOI: 10.1039/D3TB01376F

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