Issue 24, 2021

Antitumor activity of tridentate pincer and related metal complexes

Abstract

Pincer complexes featuring tunable tridentate ligand frameworks are one of the most actively studied classes of metal-based complexes. Currently, growing attention is devoted to the cytotoxicity of pincer and related metal complexes. The antiproliferative activity of numerous pincer complexes has been reported. Pincer tridentate ligand scaffolds show different coordination modes and offer multiple options for directed structural modifications. This review summarizes the significant progress in the research studies of the antitumor activity of pincer and related platinum(II), gold(III), palladium(II), copper(II), iron(III), ruthenium(II), nickel(II) and some other metal complexes, in order to provide a reference for designing novel metal coordination drug candidates with promising antitumor activity.

Graphical abstract: Antitumor activity of tridentate pincer and related metal complexes

Article information

Article type
Review Article
Submitted
25 מרץ 2021
Accepted
04 מאי 2021
First published
04 מאי 2021

Org. Biomol. Chem., 2021,19, 5254-5273

Antitumor activity of tridentate pincer and related metal complexes

S. Wu, Z. Wu, Q. Ge, X. Zheng and Z. Yang, Org. Biomol. Chem., 2021, 19, 5254 DOI: 10.1039/D1OB00577D

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