Issue 40, 2019

Tuning the reaction pathways of phenanthroline-Schiff bases: routes to novel phenanthroline ligands

Abstract

Pyrido-phenanthrolin-7-one compounds are structural analogues of the cytotoxic alkaloid, ascididemin, and would be expected to have interesting biological activities. Synthetic strategies are reported for a novel simple route to form this class of ligand. 1,10-Phenanthrolin-5,6-dione reacts with L-phenylalanine alkyl esters and their para-substituted analogues to form both a phenanthroline–oxazine and a pyrido-phenanthrolin-7-one product. The nature of the major product is dependent on the electronic properties of the para substituent. Successful metal coordination to the pyrido-phenanthrolin-7-one ligand is also presented.

Graphical abstract: Tuning the reaction pathways of phenanthroline-Schiff bases: routes to novel phenanthroline ligands

Supplementary files

Article information

Article type
Paper
Submitted
28 יול 2019
Accepted
23 ספט 2019
First published
03 אוק 2019

Dalton Trans., 2019,48, 15283-15289

Tuning the reaction pathways of phenanthroline-Schiff bases: routes to novel phenanthroline ligands

M. Ahmed, D. Rooney, M. McCann, J. Casey, K. O'Shea and B. Twamley, Dalton Trans., 2019, 48, 15283 DOI: 10.1039/C9DT03084K

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