Issue 12, 2017

Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin

Abstract

A diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin with potent anticancer activities was explored. The synthesis was based on a highly efficient gold-catalyzed glycosylation reaction with alkynylbenzoate 3-aminoglycosides as glycosyl donors. According to this strategy, a small library containing digitoxin and digoxin analogues with various 3-aminosugar scaffolds was successfully constructed.

Graphical abstract: Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin

Supplementary files

Article information

Article type
Research Article
Submitted
28 יול 2017
Accepted
05 ספט 2017
First published
06 ספט 2017

Org. Chem. Front., 2017,4, 2450-2454

Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin

J. Zeng, G. Sun, R. Wang, S. Zhang, S. Teng, Z. Liao, L. Meng and Q. Wan, Org. Chem. Front., 2017, 4, 2450 DOI: 10.1039/C7QO00648A

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