This review summarizes the properties and synthesis methods of polyA-mediated SNAs, followed by their applications in biosensing. Discussion and an outlook on future challenges in this field are also presented.
By combining polyA-mediated spherical nucleic acids with toehold mediated strand displacement reaction, a fuel-initiated DNA molecular machine has been constructed for sensitively and selectively detecting microRNA-22 in fetal bovine serum.
PolyA-functionalized AuNPs as a nanoprobe for the detection of interleukin-6.
This review discusses the assembly methods of nucleic acid-functionalized metal nanoparticles (N-MNPs), metal nanoparticles supramolecular assembly strategies, and their representative applications in biological diagnosis and therapy.
PolyA-TDF enables PCR-free qualitative detection of drug-resistant genes, integrating biosensor recognition and probe immobilization via strong adsorption to gold.