Nano-enhanced Fenton/Fenton-like chemistry: integrating peroxidase nanozymes, MOFs, and MXenes for next-generation colorimetric biosensors

Hanh An Nguyen, Nguyen Tran Truc Phuong, Nguyen Bao Tran, Thi Ngoc Diep Trinh, Ngoc Xuan Dat Mai, Ngoc Quang Tran, Nhu Hoa Thi Tran and Kieu The Loan Trinh

Nanoscale Adv., 2025, 7, 4763
DOI: 10.1039/D5NA00387C

Detection of E. coli O157:H7 using a molecularly imprinted bacterial bipolar electrode and an Au@metal–organic framework

Yunlong Liu, Panpan Liu, Mengjuan Li, Fengyang Wang, Yusong Wan, Yan Qi, Lei Ji, Xiaohui Xiong and Yuanjian Liu

Anal. Methods, 2025, 17, 8005
DOI: 10.1039/D5AY01382H

Polymeric-protein-MOF nanoparticles with stimuli-responsive disassembly and highly reproducible synthesis

Justin Van Houten, Sarah E. S. Quail, Melissa C. D'Amaral, Kezia E. Suryoraharjo, Abigail Richards, Ruben Castillo Barberi, Rachel Leigh Mander and Alana F. Ogata

Nanoscale, 2026, 18, 1456
DOI: 10.1039/D5NR02870A

MOF-based spectrophotometric sensors for cholesterol detection: current trends and challenges

Heba Abed, Rana Sabouni and Mehdi Ghommem

RSC Adv., 2024, 14, 39472
DOI: 10.1039/D4RA07476A

Hierarchical mesoporous UiO-66-NH2(Ce) as a cascade-responsive platform for uric acid detection

Zhenyu Pan, Dongxue Feng, Ming Gong, Jian Yang and Jinlou Gu

New J. Chem., 2025, 49, 7804
DOI: 10.1039/D4NJ05486E

Metal–organic framework-based nanozymes: types, activity regulation and analytical applications

Mingyue Xie, Shidun Chen, Ke Chen, Qinghuan Gao, Jiake Li, Yiying Hao and Xingyue Lu

Analyst, 2025, 150, 3011
DOI: 10.1039/D5AN00365B

MoS2 phase transition-assisted sensitive detection of cholesterol on a copper oxide@molybdenum disulfide nanocomposite

Haritha Kuttoth, Resmi V. Nair and N. Sandhyarani

J. Mater. Chem. B, 2026
DOI: 10.1039/D5TB02549D

From trash to sensor: banana peel-derived silver nanocomposite as a mimic enzyme for cholesterol detection and antibacterial applications

Salman Ullah, Muhammad Asad, Farman Ullah, Mohibullah Shah, Khaled Fahmi Fawy, Xiaoping Zhang, Wei Sun, Umar Nishan and Amir Badshah

RSC Adv., 2025, 15, 49288
DOI: 10.1039/D5RA07350B

Application of copper based single-atom nanozymes in wound healing and tumor treatment

Huina He, Bin Cheng, Qianbing Wan and Xibo Pei

J. Mater. Chem. B, 2026, 14, 455
DOI: 10.1039/D5TB02348C

Smartphone-assisted portable swabs for thiram specific analysis based on target-regulated CuWO4 nanozyme activity combined with sample pretreatment

Jia Wu, Huimei Liang, Shulan Zeng, Shulin Zhao and Fanggui Ye

Food Chemistry, 2025, 484, 144370
DOI: 10.1016/j.foodchem.2025.144370

Multi-enzyme active temperature-sensitive hydrogel with reactive oxygen species scavenging and antimicrobial capacity for diabetic wound repair

Wenxuan Fan, Ji Cheng, Yonghai Wang, Hanjing Lu, Jiacheng Li, Hanbin Deng, Xingxin Guo, Huwen Wu, Peishen Zhang, Han Zhou, Ding Luo, Zuojia Guo, Jinghua Li and Shaowen Cheng

Burns & Trauma, 2026, 14
DOI: 10.1093/burnst/tkaf076

Sulfur/nitrogen co-doped carbon-based copper nanozyme with high peroxidase-like activity for dual-channel paper-based detection of melatonin

Chenyu Zhou, Nan Wang, Yu Su, Junxue Liu, Yuntai Lv and Xingguang Su

Sensors and Actuators B: Chemical, 2024, 418, 136246
DOI: 10.1016/j.snb.2024.136246

Molecular Imprinting‐Involving Highly Selective Tetracycline Detection Platform Based on Mn2V2O7 with Excellent Oxidase‐Mimicking Activity

Huanjun Zhao, Xinxin Xu and Jin Chen

ChemNanoMat, 2024, 10
DOI: 10.1002/cnma.202400196

Research on the application of metal-organic framework (MOF)-based nanozymes in colorimetric and electrochemical detection of biomolecules

Xingxing Li, Li Fu, Fei Chen, Yanfei Lv, Shichao Zhao and Hassan Karimi-Maleh

Inorganic Chemistry Communications, 2025, 179, 114752
DOI: 10.1016/j.inoche.2025.114752

Recent advances in metal-organic framework-based nanozymes and their enabled optical biosensors for food safety analysis

Huirong Hou, Li Wang, Yibo Gao, Jianfeng Ping and Fengnian Zhao

TrAC Trends in Analytical Chemistry, 2024, 173, 117602
DOI: 10.1016/j.trac.2024.117602

Multilayer graphene oxide-supported bimetallic synergistic MoCu-TCPP metal-organic frameworks for electrochemical detection of L-tyrosine

Haimei Zhao, Xiaodan Zhou, Yuxian Zhao, Yidi Wang, Huaixiao Geng, Lu Gao, Zhichao Zhang and Shuang Han

Journal of Electroanalytical Chemistry, 2025, 996, 119435
DOI: 10.1016/j.jelechem.2025.119435

Recent Advances in Nanozyme Sensors Based on Metal–Organic Frameworks and Covalent–Organic Frameworks

Xingliang Cheng, Shuojiang Liu and Yuling Hu

Biosensors, 2024, 14, 520
DOI: 10.3390/bios14110520

CTAB-Assisted Formation of Hierarchical Porosity in Cu-BDC-NH2 Metal–Organic Frameworks and Its Enhanced Peroxidase-like Catalysis for Xanthine Sensing

Chao Tan, Junjie He, Fei Zhou, Ruicheng Xu, Yilei Gao, Robert S. Marks and Junji Li

Processes, 2025, 13, 387
DOI: 10.3390/pr13020387

Colorimetric detection and quantification of glutathione in human serum using the peroxidase-like activity of MOF-808FA frameworks

Serveh Javaheri, Jamal Hallajzadeh, Maryam Saadat and Arian Azadnia

Current Pharmaceutical Analysis, 2025, 21, 375
DOI: 10.1016/j.cpan.2025.08.002

Coencapsulating TMB Probes and Bimetallic MOF Nanozymes in a Hydrogel Patch for Fabricating Reusable Visual VC Sensors

Xilong Zhou, Zhiying Shao, Sihan Yan, Yuhang Lin, Yuanhao Liu, Xujing Feng, Junling Sha, Lijun Ding and Kun Wang

Anal. Chem., 2024, 96, 17310
DOI: 10.1021/acs.analchem.4c03665

Multi-cascade signal amplification and structure modulation strategy for highly sensitive and selective detection of cysteine using bovine serum albumin-stabilized gold nanoflowers as signal mediator

Hongyu Chen, Mengjie Hou, Ruiting Li, Manman Sun, Wenping Zhu, Weijie Yang, Zengchen Liu and Yahong Chen

International Journal of Biological Macromolecules, 2025, 307, 142142
DOI: 10.1016/j.ijbiomac.2025.142142

Naked eye detection of hydrogen peroxide via curcumin functionalised gold nanoparticles

Priya Sudhesh, S. Sruthi, Mariya Jose, K. Vyshnavi, P. Aiswarya and R. Manu

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-01613-y

Electrochemical immunosensor based on Ag@MXene and Au@MoCu-2MI nanocomposites for sensitive detection of Cyfra21-1

Chunfang Cheng, Fangqin Han, Jingyu Zhao, Chunxiao Li, Nuo Zhang, Malik Saddam Khan, Yaoguang Wang and Guanhui Zhao

Microchemical Journal, 2025, 217, 115038
DOI: 10.1016/j.microc.2025.115038

The color code: MOFs unlocking new horizons in chemical sensing

Paulina Miklaszewska and Ewa Wagner-Wysiecka

Applied Materials Today, 2025, 47, 102966
DOI: 10.1016/j.apmt.2025.102966

Co-catalytic enhancement of peroxidase-like activity of Fe-MOFs nanozymes by AuNPs for efficient specific detection of Hg2+

Yue Ren, Zixiang Liao, Yi He, Libo Li and Tianyan You

Microchemical Journal, 2025, 208, 112536
DOI: 10.1016/j.microc.2024.112536

Advances in Metal–Organic Framework-Based Nanozymes for Biosensing and Point-of-Care Testing Applications

Qingjie Fu, Shuo Tian, Shun Wang, Guoming Sun, Mengke Wang and Kelong Fan

ACS Appl. Nano Mater., 2025, 8, 17339
DOI: 10.1021/acsanm.5c02319

Laminated Au-TiO2/C Nanozyme for Ultrasensitive Detection of Cholesterol and Enhanced Bactericides

Xinxin Shi, Luqing Chen, Yu Chen, Lehan Gu, Xiuhui Wu, Guohai Yang, Chengzhou Zhu and Lu−Lu Qu

ACS Appl. Mater. Interfaces, 2025, 17, 36170
DOI: 10.1021/acsami.5c04606

Robust and sensitive colorimetric detection of glutathione with double-triggering MOF-Fe(DTNB)

Kaining Zhang, Hao Sun, Long Wei, Rui Hu, Hao Liu, Yongchao Lai and Xun Li

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 328, 125439
DOI: 10.1016/j.saa.2024.125439

Nanozyme-based biosensors with different combinations of sensing modes for clinical biomarker detection: Biosensing strategies, practical applications, and future perspectives

Xingzhi Yu, Weihua Zhuang, Weiyi Bai, Qing Li, Huiling Tan, Limei Zhang, Jiahui Zhang, Yongchao Yao, Shufen Li, Hao Bai, Jie Hu, Xuping Sun and Wenchuang Hu

Coordination Chemistry Reviews, 2025, 542, 216850
DOI: 10.1016/j.ccr.2025.216850

Application of MOF Nanoenzyme in Rapid Detection of Food Allergens System

Wei Wang, Xin Song, Chong Pang and Shengrong Ouyang

j biomed nanotechnol, 2024, 20, 1271
DOI: 10.1166/jbn.2024.3880

Novel nanozyme sensor array based on four different enzyme-like activities for the identification of multi-category pesticides

Jiatong Li, Qing Han, Xinyue Zhang, Linxue Zhen, Hui Huang and Yongxin Li

Journal of Hazardous Materials, 2026, 501, 140978
DOI: 10.1016/j.jhazmat.2025.140978

Rational synthesis of FeWO4 nanozyme with sonopiezoelectric and co-catalytic activity for colorimetric detection of deferiprone

Peng Shi, Shuishi Li, Ling Liang, Jia Wu, Shulin Zhao and Fanggui Ye

Microchemical Journal, 2024, 207, 112076
DOI: 10.1016/j.microc.2024.112076

Biomimetic Design of Tunable Nanozymes for Microbial Detection: A Review

Yilang Cheng, Yilin Zhao, Zhuo Wen, Heyuan Zhao, Gang Xiao and Haijia Su

ACS Appl. Nano Mater., 2025, 8, 15748
DOI: 10.1021/acsanm.5c02313

Spatially confining copper atom in flowerlike-CoFe hydroxides for smartphone-based ratiometric colorimetric dual-mode detection of nitrite

Qing Chen, Xin Yang, Ting Mao and Jiafu Xiao

Microchemical Journal, 2024, 201, 110578
DOI: 10.1016/j.microc.2024.110578

Accelerating the Phosphatase-like Activity of Uio-66-NH2 by Catalytically Inactive Metal Ions and Its Application for Improved Fluorescence Detection of Cardiac Troponin I

Yuefei Luo, Yusha Huang, Longcheng Gong, Min Wang, Zhining Xia and Lianzhe Hu

Anal. Chem., 2024, 96, 2684
DOI: 10.1021/acs.analchem.3c05499

Breaking through the pH Limitation of Fe1–xS Nanozymes Using Component-Modulated Coupled Nanoclay

Wenxin Bao, Luyuan Tian, Hao Wang, Aidong Tang and Huaming Yang

Inorg. Chem., 2024, 63, 3366
DOI: 10.1021/acs.inorgchem.3c03934

Real-time and visual monitoring coating damage and metal corrosion based on the multiple chromatic transition of TMB triggered by highly active N-CDs/Fe3O4 peroxidase mimics and Fe3+

Tianfei Qi, Ruonan Jia, Linbo Zhang, Guanyu Li, Xuefeng Wei, Jianting Ye, Ruilian Qi and Haiyuan Chen

Sensors and Actuators B: Chemical, 2024, 415, 136003
DOI: 10.1016/j.snb.2024.136003

A “super-off” photoelectrochemical biosensor based on Cu-BTC nanozyme quenching strategy for the detection of dibutyl phthalate plasticizer

Yajuan Liu, Shuai Wang, Yaqin Chai, Ruo Yuan, Hongbo Li and Hongyan Liu

Talanta, 2025, 284, 127241
DOI: 10.1016/j.talanta.2024.127241

Revolutionizing nanozyme technology with metal-organic frameworks: Classification, catalytic mechanisms, regulation and applications in biotechnology

Yiran Wang, Yaqiong Yang, Jiachen Liu, Xiangyu Zi, Huayue Zhu, Xiaolong Sun, Yingjie Miao and Yongqian Fu

Chemical Engineering Journal, 2024, 500, 156850
DOI: 10.1016/j.cej.2024.156850

Metal ions-driven multi-enzyme activity of PEI-carbon dots-based nanozyme to improve antibacterial ability

Qiuting Duan, Linyan Tang, Sanchun Xu, Dezhi Yang and Ya Xu

Chemical Engineering Journal, 2025, 511, 161957
DOI: 10.1016/j.cej.2025.161957

Highly stable enhanced peroxidase‐like new metal–organic framework for the colorimetric detection of phenol and hydrogen peroxide

Viktoriya Kim, Dong Woo Lee, Hye Ran Noh, Jong‐Yun Kim, Tung Cao‐Thanh Pham, Sang Ho Lim and Hyun Sung Kim

Bulletin Korean Chem Soc, 2025, 46, 957
DOI: 10.1002/bkcs.70063

Fe/Co-MOF-based cascade biocatalytic platform for ultrasensitive detection of α-amylase

Huan Liu, Yanlin Wang, Chaoqian Wu, Wanqiu Huang, Yin Han and Shaoning Yu

Microchim Acta, 2026, 193
DOI: 10.1007/s00604-026-07993-w

Bioactive Metal–Organic Frameworks as a Distinctive Platform to Diagnosis and Treat Vascular Diseases

Wen Liu, Ying Li, Yuanchao Wang and Yakai Feng

Small, 2024, 20
DOI: 10.1002/smll.202310249

Advances in the application of sensor arrays based on nanozymes

Ying Ma, Heng Liu, Bin Li and Na Lu

Biosensors and Bioelectronics: X, 2024, 21, 100542
DOI: 10.1016/j.biosx.2024.100542

Light/ultrasound enhance peroxidase activity of BaTiO3/graphdiyne/Au nanozyme for colorimetric detection of E. coli O157:H7

Di Zhang, Haoxin Li, Kai Wang, Yujian Sun, Chenguang Wang, Yingying Wang, Qiang Bai, Tianzhi Yu, Zhugen Yang, Ning Sui and Lina Wang

Sensors and Actuators B: Chemical, 2025, 430, 137378
DOI: 10.1016/j.snb.2025.137378

Rapid visual detection of glutathione in vegetables and distinguishing multiple sulfur-containing compounds by smartphone-assisted sensor based on calcined PPy@CuNi-ZIF-67 nanozyme with enhanced oxidase-like activity

Linchun Nie, Jiazhi Xia, Jiawei Liao, Na Liu, Meiling Xu, Dejing Meng, Wenjing Liu, Qingxiang Zhou and Chunmao Chen

Food Chemistry, 2025, 474, 143189
DOI: 10.1016/j.foodchem.2025.143189

Integrating molecular imprinting and Fe-based MOF peroxide-like nanozyme for highly sensitive and selective detection of diethylstilbestrol

Changchang Li, Yue Zhi, Minnan Zhu, Chengyu Yang, Yayang Tian, Tao Chen, Yuan Zhao, Jie Gao and Linfeng Chen

Microchemical Journal, 2024, 207, 112033
DOI: 10.1016/j.microc.2024.112033

Photoelectrochemical aptasensing of prostate-specific antigen using an engineered FeIn2S4/Bi2O2S heterojunction

Weilu Liu, Siyao Hu, Jing Zhao, Zehao Fang, Junyan Wang and Heinz-Bernhard Kraatz

Chemical Engineering Journal, 2026, 534, 175158
DOI: 10.1016/j.cej.2026.175158

One‐Step Synthesis of Self‐Assembled Flower Shape CuNi‐MOF‐Based Nanocomposite for Non‐Enzymatic Electrochemical Sensing of Atrazine in Real Sample

Shital Jyotsna Sahoo, Bhismadev Mahananda, Jyotiraditya Samantaray, Jaspreet Singh and Priyabrat Dash

Applied Organom Chemis, 2025, 39
DOI: 10.1002/aoc.70342

A novel laccase-like Cu-MOF for colorimetric differentiation and detection of phenolic compounds

Ziyi Gao, Jianping Guan, Meng Wang, Shenghong Liu, Kecen Chen, Qi Liu and Xiaoqing Chen

Talanta, 2024, 272, 125840
DOI: 10.1016/j.talanta.2024.125840

Synthesis of a COF-on-MOF hybrid nanomaterial for enhanced colorimetric biosensing

Haojie Xie, Lin Wang, Xiaomeng Yu, Tianci Zhou, Minghui Wang, Jie Yang, Tao Gao and Genxi Li

Talanta, 2024, 274, 126071
DOI: 10.1016/j.talanta.2024.126071

Mo-Incorporated Bimetallic Metal–Organic Framework for Electrochemical Detection of Hydrogen Peroxide: A Potential Biomimic System

Aswathi Mechoor, K. S. Lavanya Shri, Sheela Berchmans and V. Ganesh

Electrocatalysis, 2025, 16, 28
DOI: 10.1007/s12678-024-00891-w

Boron-doped g-C3N4 supporting Cu nanozyme for colorimetric-fluorescent-smartphone detection of α-glucosidase

Qingjie Fu, Shuang Liang, Siqi Zhang, Chenyu Zhou, Yuntai Lv and Xingguang Su

Analytica Chimica Acta, 2024, 1311, 342715
DOI: 10.1016/j.aca.2024.342715

Cu@MOF core-shell aerogel: High enzyme-like activity for ultratrace colorimetric detection of Hg2+ ions

Juan Li, Xiaoyue Shi, Wenjing Gao, Youcong Li, Zhenhuai Ma, Shuai Yuan, Jinhua Zhan and Bin Cai

Sensors and Actuators B: Chemical, 2024, 417, 136200
DOI: 10.1016/j.snb.2024.136200

FeBTC as peroxidase mimic for colorimetric cholesterol detection

Heba Abed, Rana Sabouni, Mehdi Ghommem, Muhammad Umar Azam, Khalid Askar and Nouha Alcheikh

Sci Rep, 2025, 16
DOI: 10.1038/s41598-025-32611-9

Metal-organic frameworks: Biosensor applications for diagnosis of cancers

Mojtaba Hosseine, Seyed Morteza Naghib and Navid Rabiee

Microchemical Journal, 2025, 208, 112341
DOI: 10.1016/j.microc.2024.112341

Bimetallic Cu–Zn Zeolitic Imidazolate Frameworks as Peroxidase Mimics for the Detection of Hydrogen Peroxide: Electrochemical and Spectrophotometric Evaluation

Aswathi Mechoor, Sheela Berchmans and Ganesh Venkatachalam

ACS Omega, 2023, 8, 39636
DOI: 10.1021/acsomega.3c05535

Copper-based fluorescent nanozyme used to construct a ratiometric sensor for visual detection of thiophanate methyl

Shuyi Liu, Hong Yu, Shuyun Zhu and Xian-En Zhao

Talanta, 2025, 285, 127417
DOI: 10.1016/j.talanta.2024.127417

Bacterial Outer Membrane Vesicle-Based Nanoreactor for Enhanced Photodynamic Therapy of Breast Cancer

Lu-Xin Liu, Zhong-Xia Lu, Lei Qi, Bai-Hai Wu, Sheng-Nan Wang, Xuan-Ping Xu, Feng Han, Xin-Zhi Lu and Wen-Gong Yu

ACS Appl. Nano Mater., 2026, 9, 2309
DOI: 10.1021/acsanm.5c04941

Bimetallic Valence Modulation Strategy Boosted Peroxidase-/Laccase-like Activity of a MoCu-2MI MOF Nanozyme for Portable-Device-Enabled Trimodal Sensing of D-Penicillamine and Colorimetric Analysis of Phenolic Pollutants

Daoqing Fan, Shuai Qin, Chuanping Li, Yujia Ren, Lilin Hao, Hengqian Zhang, Jiawen Han, Jingyu Hou, Juan Wang and Shaojun Dong

Anal. Chem., 2025, 97, 28363
DOI: 10.1021/acs.analchem.5c05901

Nanozymes in the field of antibacterial applications: mechanisms and optimization strategies

Zheng Hu, Huarong Xu, Yiduo Ding, Qing Zhou, Shuaipeng Feng, Yian Li, Donghua Di, Siling Wang and Qinfu Zhao

Coordination Chemistry Reviews, 2025, 543, 216939
DOI: 10.1016/j.ccr.2025.216939

Smartphone-assisted array sensor constructed with Cu, Ni doped ZIF-67 nanozyme for specific identification of sulfur-containing compounds and detection of thioglycolic acid

Guojin Tang, Linchun Nie, Shuai Yuan, Liushan Jiang, Jiawei Liao, Na Liu, Dejing Meng, Wenjing Liu and Qingxiang Zhou

Microchemical Journal, 2025, 217, 115045
DOI: 10.1016/j.microc.2025.115045