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Recent progress of porphyrin metal–organic frameworks for combined photodynamic therapy and hypoxia-activated chemotherapy

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G-quadruplex-driven molecular disassembly and type I-to-type II photophysical conversion of a heavy-atom-free photosensitizer for site-specific oxidative damage

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A dual-targeting photosensitizer for simultaneous mitochondrial and lysosomal disruption in cancer and antibacterial photodynamic therapy

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Mitochondria-targeting cyclometallated rhodium(iii) complexes appended with two rhodamine units as Type I photosensitisers for bioimaging and photocytotoxicity applications by inducing pyroptosis

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Achieving red-light anticancer photodynamic therapy under hypoxia using Ir(iii)–COUPY conjugates

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Mechanism-guided design of specific-activated photosensitizers for precision photodynamic therapy

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A nuclear targeted type-I photosensitizer for anti-tumor therapy

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Use of photosensitive molecules in the crosslinking of biopolymers: applications and considerations in biomaterials development

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Heavy-atom-free BODIPY-based photodynamic therapy agents activated at long wavelengths

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Recent advances in near-infrared organic photosensitizers for photodynamic cancer therapy

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Targeting sub-cellular organelles for boosting precision photodynamic therapy

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Photodynamic Therapy-Induced Anti-Tumor Immunity: Influence Factors and Synergistic Enhancement Strategies

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Pharmaceutics, 2023, 15, 2617
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Aggregation-Induced Emission Materials for Tumor Phototheranostics

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Chinese Journal of Organic Chemistry, 2024, 44, 2413
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Acid-Responsive Thiocarbonylated Coumarin Photosensitizer for Hypoxia-Tolerant Photodynamic Therapy

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Single Molecule for Trifecta PDT: Tailor-Made Three-Organelle-Targeting Type I Photosensitizer for Cancer Cell-Selective Photodynamic Therapy under Hypoxia

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Systematic review: Mechanisms of photoactive nanocarriers for imaging and therapy including controlled drug delivery

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Porphyrin‐Based Carbon Dots: Navigating the Nanoscale Frontier of Precision Biomedicine

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Trithio‐naphthalic anhydride‐based photosensitizer for photodynamic activity

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Bulletin Korean Chem Soc, 2026
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Isolation, Synthesis, and Use of Natural Photosensitizers in the Treatment of Central Nervous System Tumors

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Chemistry, 2025, 7, 148
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A versatile 980 nm excitable small molecule for short-wave infrared fluorescence imaging guided type-I photodynamic/photothermal therapy

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Activatable Photosensitizers: From Fundamental Principles to Advanced Designs

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Are tumour-associated carbonic anhydrases genuine therapeutic targets for photodynamic therapy?

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Recent advancement in photosensitizers for photodynamic therapy

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Charge Transfer Reactions (PDT Reaction I) Induced at 1064 nm (NIR-II) between Rhodamines and Folic Acid as the Basis for Biphotonic Photodynamic Therapy

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Dual enzyme responsive resorufin-based type-I/II photosensitizer for selective treatment of neuroblastoma cells under hypoxia

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Recent advances in NIR-II photothermal and photodynamic therapies for drug-resistant wound infections

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Materials Today Bio, 2025, 32, 101871
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Efficient type Ⅰ and type Ⅱ ROS generated aggregation-induced emission photosensitizer for mitochondria targeted photodynamic therapy

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Recent Advances in Near-Infrared Cyanine Dye-Based Fluorescent Nanoprobes for Tumor Imaging and Therapy

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Self-Reporting Conjugated Polymer Nanoparticles for Superoxide Generation and Detection

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OXPHOS-targeted nanoparticles for boosting photodynamic therapy against hypoxia tumor

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Molecularly Engineered Near-Infrared Aggregation-Induced Emission Photosensitizer for In Situ-Activated Light Irradiation-Free Photodynamic Therapy

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A Hypoxia‐Triggered Bioreduction of Hydrophilic Type I Photosensitizer for Switchable In Vivo Photoacoustic Imaging and High‐Specificity Cancer Phototherapy

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Anthraquinone-Centered Type I Photosensitizer with Aggregation-Induced Emission Characteristics for Tumor-Targeted Two-Photon Photodynamic Therapy

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激发态动力学在有机光学诊疗材料中的应用

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Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: Alleviating, exploiting and disregarding

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Nanoparticle-driven reactive oxygen species therapy: A new frontier in osteosarcoma treatment

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Fluorescent Albumin-Binding N-Propylbenzene Indolenine-Based Squaraines as Potential Candidates for Prostate Cancer Photodynamic Therapy Photosensitizers

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Rational Design of Type‐I Photodynamic Agents

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A Nitroreductase-Responsive Type I Photosensitizer with Aggregation-Induced Emission Characteristics for Precise Hypoxic Cancer Theranostics

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Atomic Engineering and Aggregation Effect to Regulate Synergistically Type I Reactive Oxygen Species of AIE‐Active Deep Red/Near Infrared Red Photosensitizer

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Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy

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Synergistic action of combining photodynamic therapy with immunotherapy for eradicating solid tumors in animal models: A systematic review

Ghazal Farahavar, Samira Sadat Abolmaali, Roya Biabanikhankahdani and Ali Mohammad Tamaddon

Critical Reviews in Oncology/Hematology, 2025, 209, 104691
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π-conjugated molecule Y6 combined with an electron sacrificial agent boosts photodynamic therapy via enhanced glutathione photooxidation

Zhimin Gao, Qian Zhang, Ziyan Huang, Feng Jin, Yongxin Huang, Xinyi Wang, Chen Lin, Guokang Chen, Chuanlong Wu, Fangwei Zhang, Wei Chen, Jiajia Wang and Zhiyao Hou

Precision Medicine and Engineering, 2026, 3, 100066
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Porphyrin-assembled nano-photosensitizer with near-infrared response for highly efficient type I photodynamic and photothermal therapy

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Mitochondrial-Targeting Nanotrapper Captured Copper Ions to Alleviate Tumor Hypoxia for Amplified Photoimmunotherapy in Breast Cancer

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ACS Appl. Mater. Interfaces, 2024, 16, 2166
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Advances in Photodynamic Therapy: Photosensitizers, Biological Mechanisms, and Artificial Intelligence-Driven Innovation

Jadwiga Inglot, Dorota Bartusik-Aebisher, Katarzyna Bania, Klaudia Dynarowicz and David Aebisher

Chemistry, 2026, 8, 31
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Novel one-/two-photon excited carbazole/quinolinium photosensitizers manifest nanomolar and hypoxia-resistant tumor photodynamic therapy by accelerating apoptosis, ferroptosis, and autophagy

Tiantian Sun, Kai Wang, Yifan Ma, Xiao Liu, Dongliang Ji, Zirui Zhang, Xudong Xie, Zhifei Yuan, Lei Wang, Gong-Qing Liu and Yong Ling

European Journal of Medicinal Chemistry, 2025, 290, 117523
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Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics

Yifan Di, Ruizhu Deng, Zhu Liu, Yuling Mao, Yikun Gao, Qinfu Zhao and Siling Wang

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Nanozyme-Based Cancer Nanotheranostics: Emerging Applications and Challenges in Brain Cancer Therapeutics

Alexandra A. P. Mansur and Herman S. Mansur

JNT, 2025, 6, 4
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Photocatalytic Production of Hydrogen Peroxide in Hypoxic Cancer Cells Enabled by Loose Ordered-Assembled Photosensitizer

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Silica-induced ROS in alveolar macrophages and its role on the formation of pulmonary fibrosis via polarizing macrophages into M2 phenotype: a review

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Biomolecule–Photosensitizer Conjugates: A Strategy to Enhance Selectivity and Therapeutic Efficacy in Photodynamic Therapy

Dominik M. Płaskonka, Dominik Barczyk, Paweł Repetowski, Marta Warszyńska and Janusz M. Dąbrowski

Pharmaceuticals, 2025, 19, 65
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Optical and Supramolecular Properties of Cyclometalated Palladium Nanostructures with Tumor Targeting Properties in Living Mice: A Quantum Mechanics Interpretation.

Costantino Zazza, Nico Sanna, Stefano Borocci and Felice Grandinetti

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An Electron Donor–Acceptor Structured Rhenium(I) Complex Photo‐Sensitizer Evokes Mutually Reinforcing "Closed‐Loop" Ferroptosis and Immunotherapy

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Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitizers for the Efficient Phototherapy of Hypoxic Tumors

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Rational Design of Naphthalimide-Based Type I Two-Photon Photosensitizers for Photodynamic Therapy

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Photo‐Induced Disproportionation‐Mediated Photodynamic Therapy: Simultaneous Oxidation of Tetrahydrobiopterin and Generation of Superoxide Radicals

Kun‐Xu Teng, Dongsheng Zhang, Bin‐Kai Liu, Zheng‐Fei Liu, Li‐Ya Niu and Qing‐Zheng Yang

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Selective antibacterial and antibiofilm activity of chlorinated hemicyanine against gram-positive bacteria

Nazli Atac, Hande Gunduz, Irem Koc, Kubra Onbasli, Minahil Khan, Samira Savani, Alphan Sennaroglu, Fusun Can, Havva Yagci Acar and Safacan Kolemen

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Optimizing Photosensitizers with Type I and Type II ROS Generation Through Modulating Triplet Lifetime and Intersystem Crossing Efficiency

Yifan Yue, Bowen Li, Dandan Wang, Chongzhi Wu, Zhiyao Li and Bin Liu

Adv Funct Materials, 2025, 35
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The revolution of type I organic photosensitizers: current strategies and future directions

Mengyao Yang, Luyan Zhou, Yuan-Yuan Zhao, Kunemadihalli Mathada Kotraiah Swamy, Aibing Chen and Juyoung Yoon

Science Bulletin, 2025, 70, 1203
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NIR-triggered synergistic Photothermal therapy and type I photodynamic therapy using supramolecular porphyrin-Phthalocyanine assemblies for the treatment of multidrug-resistant bacterial infections

Wei Su, Jiayin Chen, Chenxiang Lin, Jun-An Xiao and Peiyuan Li

Bioorganic Chemistry, 2026, 171, 109558
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Organelle-Specific Thiochromenocarbazole Imide Derivative as a Heavy-Atom-Free Type I Photosensitizer for Biomolecule-Triggered Image-Guided Photodynamic Therapy

Karolina Saczuk, Ahmad Kassem, Marta Dudek, Darío Puchán Sánchez, Lhoussain Khrouz, Magali Allain, Gregory C. Welch, Nasim Sabouri, Cyrille Monnereau, Pierre Josse, Clément Cabanetos and Marco Deiana

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Recent Advances in Photodynamic Therapy: Metal-Based Nanoparticles as Tools to Improve Cancer Therapy

Stefania Mariano, Elisabetta Carata, Lucio Calcagnile and Elisa Panzarini

Pharmaceutics, 2024, 16, 932
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Boosting curcumin derivatives' cytotoxicity in cancer cells with light: An in vitro study

Giulia Greco, Eleonora Turrini, Fabio Ferrini, Francesca Maffei, Giulia Neggiani, Matteo Calvaresi, Manuele Di Sante, Matteo Di Giosia, Federica Belluti, Piero Sestili and Carmela Fimognari

Biomedicine & Pharmacotherapy, 2025, 192, 118643
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A Hypoxia‐Triggered Bioreduction of Hydrophilic Type I Photosensitizer for Switchable In Vivo Photoacoustic Imaging and High‐Specificity Cancer Phototherapy

Yuan‐Yuan Zhao, Yihui Xu, Xiaojun Zhang, Zixuan Chen, Heejeong Kim, Xingshu Li and Juyoung Yoon

Angew Chem Int Ed, 2025, 64
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Engineering organic, inorganic, carbon, and hybrid materials for skin cancer theragnostic: a focus on melanoma and non-melanoma

Pachaiyappan Murugan, Vijayapoopathi Singaravel, Chitrarasu Manikandan, Loganathan Praburaman, Meivelu Moovendhan, Kirubakaran Dharmalingam and Shi-Yong Liu

Microchim Acta, 2026, 193
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Near-infrared photosensitizers adaptive to tumor hypoxic microenvironment for synergistic photothermal-photodynamic and immunotherapy

Xiangchun Meng, Yufang Han, Shaobo Wang, Xueyu Wang, Zeyu Zhang, Shuncheng Yao, Xingyi Wan, Zhirong Liu, Ziyi Ge and Linlin Li

Nano Today, 2023, 53, 102030
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A non-ionic phenothiazine-derived type I photosensitizer

Zhe Liu, Na Li, Ke Cheng, Qian Liu, Weijie Chi, Ji-Ting Hou and Jianliang Shen

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2026, 349, 127387
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Revolutionizing cancer therapies with organic photovoltaic non-fullerene acceptors: A deep dive into molecular engineering for advanced phototheranostics

Yaojun Li, Yun Li, Shenglong Liao, Yang Li and Shouchun Yin

Chinese Chemical Letters, 2025, 36, 110832
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Metal–Organic Frameworks for Precision Phototherapy of Breast Cancer

Fan Qi, Haitao Ren, Beibei Bie, Qiaofeng Wang, Guodong Fan, Zhaona Liu, Huanle Fang and Chuanyi Wang

Molecules, 2026, 31, 544
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Phenolato TiIV Complexes as Bifunctional Antitumor Agents: Synergistic Photodynamic Therapy, In Situ TiIII-Mediated Cytotoxicity, and Immune Activation

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Recent Progress of Molecular Design in Organic Type I Photosensitizers

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The Current Advances in Design Strategy (Indirect Strategy and Direct Strategy) for Type‐I Photosensitizers

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Advanced Science, 2025, 12
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Fluorescein-Functionalized Iridium(III) Complexes as Dual-Mode Type I Photosensitizers for Hypoxia-Tolerant Photodynamic and X-ray-Induced Therapy

Ji-Qiang Liu, Anfernee Kai-Wing Tse, Martina Koncošová, Tomáš Ruml, Yu-Chung Tse, Chuang-Jun Liu, Jaroslav Zelenka, Kaplan Kirakci, Kamil Lang, Chi-Sing Lee and Keith Man-Chung Wong

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Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

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Metabolic–photoimmunotherapy: A Shikonin–NIR-I photosensitizer nanoplatform reprograms glycolysis to potentiate phototherapy-induced antitumor immunity in hepatocellular carcinoma

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Oxygen tension regulating nanoformulation for the improved photodynamic therapy of hypoxic tumors

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The Development of meso-Methyl-BODIPY Conjugates with Boc-seco-CBI and Cabozantinib: The Practical Challenges of Red-Light-Activated Prodrugs for Anticancer PDT

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