Hybrid lipoplex co-delivering siPD-L1/miR-140-5p reverses T cell exhaustion via post-transcriptional regulation for in situ photothermal vaccination

Qunjie Bi, Huan Yang, Shiyi Li, Haoyue Chen, Yichun Wang, Binbin Yang, Tao Zhang, Xia He, Matthias Barz, Heyang Zhang, Rongrong Jin and Yu Nie

Nanoscale, 2026, 18, 5295
DOI: 10.1039/D5NR05275K

Hybrid Lipoplex Boosts Neuron‐Microglia Crosstalk for Treatment of Alzheimer's Disease through Aβ‐Targeted‐Autophagy and ApoE2 Gene Supplementation

Yiyao Pu, Xue‐Lin Dai, Yichun Wang, Yanbing Chen, Chengheng Wu, Xiangyu Zhou, Meiwan Chen, Yi‐Hung Chen, Xintao Shuai, Rongrong Jin and Yu Nie

Advanced Materials, 2025, 37
DOI: 10.1002/adma.202418560

Aged-Signal-Eliciting Nanoparticles Stimulated Macrophage-Mediated Programmed Removal of Inflammatory Neutrophils

Kaige Chen, Zheng Zhang, Ziyuan Fang, Jiachen Zhang, Qian Liu, Wang Dong, Yang Liu, Yucai Wang and Jun Wang

ACS Nano, 2023, 17, 13903
DOI: 10.1021/acsnano.3c03815

Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery

Lulu Xue, Gan Zhao, Ningqiang Gong, Xuexiang Han, Sarah J. Shepherd, Xinhong Xiong, Zebin Xiao, Rohan Palanki, Junchao Xu, Kelsey L. Swingle, Claude C. Warzecha, Rakan El-Mayta, Vivek Chowdhary, Il-Chul Yoon, Jingcheng Xu, Jiaxi Cui, Yi Shi, Mohamad-Gabriel Alameh, Karin Wang, Lili Wang, Darrin J. Pochan, Drew Weissman, Andrew E. Vaughan, James M. Wilson and Michael J. Mitchell

Nat. Nanotechnol., 2025, 20, 132
DOI: 10.1038/s41565-024-01747-6

Chitosan polyplexes for targeted gene delivery: From mechanisms to clinical applications

Radhika Joshi, Tripti Paliwal, Swapnil Sharma, Devesh U. Kapoor and Bhupendra G. Prajapati

Carbohydrate Polymers, 2025, 368, 124080
DOI: 10.1016/j.carbpol.2025.124080

The hybrid lipoplex induces cytoskeletal rearrangement via autophagy/RhoA signaling pathway for enhanced anticancer gene therapy

Xueyi Hu, Yichun Wang, Ruohan Wang, Yiyao Pu, Rongrong Jin, Yu Nie and Xintao Shuai

Nat Commun, 2025, 16
DOI: 10.1038/s41467-024-55727-4

Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery

Pei Huang, Hongzhang Deng, Changrong Wang, Yongfeng Zhou and Xiaoyuan Chen

Advanced Materials, 2024, 36
DOI: 10.1002/adma.202307822

Emerging lipid nanoparticle systems capable of efficient intramuscular RNA delivery

Aun Raza, Runtong Zhang, Ruonan Lu, Jingyuan Wen and Wei Wu

Nanomedicine, 2025, 20, 2545
DOI: 10.1080/17435889.2025.2555507

Leveraging high-throughput screening technologies in targeted mRNA delivery

Yuchen Zhang, Zhifei Gao, Xiao Yang, Qinglong Xu and Yao Lu

Materials Today Bio, 2024, 26, 101101
DOI: 10.1016/j.mtbio.2024.101101

ATRA derived lipid nanoparticles for co-delivery of siCYP26A1 to overcome metabolic limitations of differentiation therapy in solid tumors

Huan Yang, Yiyao Pu, Xueyi Hu, Haili Zhang, Shiyi Li, Wei Zhang, Meiwan Chen, Heyang Zhang, Rongrong Jin and Yu Nie

Journal of Controlled Release, 2025, 384, 113933
DOI: 10.1016/j.jconrel.2025.113933

Endo/Lysosomal-Escapable Lipid Nanoparticle Platforms for Enhancing mRNA Delivery in Cancer Therapy

Jiapeng Wang, Renjie Chen, Yongyi Xie, Xuanting Qin, You Zhou and Chuanshan Xu

Pharmaceutics, 2025, 17, 803
DOI: 10.3390/pharmaceutics17070803

A novel proliferation synergy factor cocktail maintains proliferation and improves transfection efficiency in muscle cells and fibroblasts under low-serum conditions

Jianan Li, Jingqi Huang, Zeyang Gao, Chunpeng He, Zaiyan Xu and Bo Zuo

Front. Cell Dev. Biol., 2025, 13
DOI: 10.3389/fcell.2025.1680263

Fibrous topology promoted pBMP2-activated matrix on titanium implants boost osseointegration

Ting He, Yichun Wang, Ruohan Wang, Huan Yang, Xueyi Hu, Yiyao Pu, Binbin Yang, Jingyuan Zhang, Juan Li, Chongxiang Huang, Rongrong Jin, Yu Nie and Xingdong Zhang

Regenerative Biomaterials, 2024, 11
DOI: 10.1093/rb/rbad111

Ether bond-modified lipid nanoparticles for enhancing the treatment effect of hepatic fibrosis

Runxuan Chu, Jianglong Kong, Qiang Gao, Yani Yang, Ting Pan, Xiaohong Lu, Zhefeng Wang, Yi Wang and Jun He

International Journal of Pharmaceutics, 2025, 671, 125192
DOI: 10.1016/j.ijpharm.2025.125192

Molecular Chameleon Carriers for Nucleic Acid Delivery: The Sweet Spot between Lipoplexes and Polyplexes

Sophie Thalmayr, Melina Grau, Lun Peng, Jana Pöhmerer, Ulrich Wilk, Paul Folda, Mina Yazdi, Eric Weidinger, Tobias Burghardt, Miriam Höhn, Ernst Wagner and Simone Berger

Advanced Materials, 2023, 35
DOI: 10.1002/adma.202211105

Design and evaluation of methionine based sulfonium lipid for nucleic acid delivery

Jing Li, Yue Lin, Xinrui Bi, Wenyang Chen, Chenghao Jin, Yan Sun and Guinan Shen

Journal of Drug Delivery Science and Technology, 2025, 108, 106956
DOI: 10.1016/j.jddst.2025.106956

Aromatic Ionizable Lipids Enhance mRNA Delivery via Coordinating Multiple Mechanisms

Lixin Lin, Xinyue Zhang, Xinxin Yan, Lu Shi, Kexin Su, Shun He, Mengyao Yu, Xudong Fu, Xin Sheng, Na Kong and Shuai Liu

J. Am. Chem. Soc., 2026, 148, 6960
DOI: 10.1021/jacs.5c16971

Boosting Lipofection Efficiency Through Enhanced Membrane Fusion Mechanisms

Rais V. Pavlov, Sergey A. Akimov, Erdem B. Dashinimaev and Pavel V. Bashkirov

IJMS, 2024, 25, 13540
DOI: 10.3390/ijms252413540

Interactions of lipid nanocarriers with a bacterial model membrane

Biserka Lakic, Ewan W. Blanch, Brendan Dyett and Charlotte E. Conn

Journal of Colloid and Interface Science, 2026, 702, 138833
DOI: 10.1016/j.jcis.2025.138833