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Mechanistic elucidation of enzymatic C-glycosylation: facilitation by proton transfer to UDP-glucose

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Progress in Identification of UDP-Glycosyltransferases for Ginsenoside Biosynthesis

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Mechanistic origin of C- over O-glycosylation in glycosyltransferase GgCGT: a QM/MM study

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Bulletin of the Chemical Society of Japan, 2026, 99
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Discovery of glycosidated glycyrrhetinic acid derivatives: Natural product-based soluble epoxide hydrolase inhibitors

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Functional and structural dissection of glycosyltransferases underlying the glycodiversity of wolfberry-derived bioactive ingredients lycibarbarspermidines

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Highly Regio-/Stereoselective Synthesis of Carbohydrates with Unsaturated Glycosyl Donors under Mild Conditions

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Synlett, 2025, 36, 1179
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Structure‐Function Analysis of the S‐Glycosylation Reaction in the Biosynthesis of Lincosamide Antibiotics

Takahiro Mori, Xin Sun, Stanislav Kadlcik, Jiri Janata and Ikuro Abe

Angewandte Chemie, 2023, 135
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Genome-wide analysis of UDP-glycosyltransferase family in Citrus sinensis and characterization of a UGT gene encoding flavonoid 1–2 rhamnosyltransferase

Jing Chen, Xiaojun Qiu, Zhimin Sun, Mingbao Luan and Jianhua Chen

International Journal of Biological Macromolecules, 2024, 280, 135752
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Identification of UDP-dependent glycosyltransferases in the wallflower cardenolide biosynthesis pathway

Owen S. Patrick, Gordon C. Younkin, Rebecca G. Brody, Jessica W. Hem, Georg Jander and Cynthia K. Holland

Journal of Biological Chemistry, 2025, 301, 108565
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Uncovering the Functional Role of UGT73F/P Subfamilies toward Triterpenoids Glycosylation in Legume Medicinal Plants

Liang Zhang, Xinhe Liu, Yongxing Li, Xudong Feng and Chun Li

ACS Synth. Biol., 2026
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Gastrointestinal digestion of olive leaf waste from olive mill production chain in a simulator of the gastrointestinal tract

María Esther Martínez‐Navarro, Jorge Escobar‐Talavera, Cristina Cebrián‐Tarancón, Silvia Llorens, Gonzalo L Alonso and M. Rosario Salinas

J Sci Food Agric, 2024, 104, 7550
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Directed Evolution of the UDP-Glycosyltransferase UGTBL1 for Highly Regioselective and Efficient Biosynthesis of Natural Phenolic Glycosides

Chenhao Zhang, Yongchao Cai, Zehua Zhang, Nan Zheng, Huimin Zhou, Yumeng Su, Shuang Du, Asif Hussain and Xiaole Xia

J. Agric. Food Chem., 2024, 72, 1640
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Functional Characterization of UGT90A2 and Its Application in One-Pot Synthesis of Quercetin 3,4′-di-O-β-d-glucoside

Yu-Feng Mao, Rui-Qi Su, Jun-Hui Bi, Ruo-Lin Wang, Li-Wen Zhu, Xiaonan Liu, Qingqing Bi, Han Hu and Kai-Zhi Jia

J. Agric. Food Chem., 2026, 74, 8473
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Discovery, characterization, and comparative analysis of new UGT72 and UGT84 family glycosyltransferases

Tuo Li, Annika J. E. Borg, Leo Krammer, Hansjörg Weber, Rolf Breinbauer and Bernd Nidetzky

Commun Chem, 2024, 7
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Characterization and Engineering of Multifunctional Glycosyltransferase HtUGT73EW3 for the Highly Efficient Synthesis of Flavonoid Mono/di-O-glycosides

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J. Agric. Food Chem., 2025, 73, 9144
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Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3

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ACS Catal., 2024, 14, 475
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Hidden O‐Deglycosylation Activity Triggers O → C Rearrangement for Aryl Di‐C‐Glucoside Formation by the C‐Glycosyltransferase From Fortunella crassifolia

Tuo Li, Annika J. E. Borg, Leo Krammer, Rolf Breinbauer and Bernd Nidetzky

Biotech & Bioengineering, 2026
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Lectin microarray based glycan profiling of exosomes for dynamic monitoring of colorectal cancer progression

Xudong Sun, Bowen Chen, Yongjie Shan, Minghong Jian and Zhenxin Wang

Analytica Chimica Acta, 2024, 1316, 342819
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Engineering an Ancestral Glycosyltransferase for Biosynthesis of 2-Phenylethyl-β-d-Glucopyranoside and Salidroside

Ting Zhang, Shaowei Tian, Zhen Gao, Yan Li and Honghua Jia

J. Agric. Food Chem., 2024, 72, 19966
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Enzymmaschinerie für bakteriellen Glucosidmetabolismus über einen konservierten nicht‐hydrolytischen Abbauweg

Klara Kastner, Johannes Bitter, Martin Pfeiffer, Christoph Grininger, Gustav Oberdorfer, Tea Pavkov‐Keller, Hansjörg Weber and Bernd Nidetzky

Angewandte Chemie, 2024, 136
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Structural and biochemical basis for regiospecificity of the flavonoid glycosyltransferase UGT95A1

Sasilada Sirirungruang, Vincent Blay, Yasmine F. Scott, Jose H. Pereira, Michal Hammel, Collin R. Barnum, Paul D. Adams and Patrick M. Shih

Journal of Biological Chemistry, 2024, 300, 107602
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Solvent Engineering for Nonpolar Substrate Glycosylation Catalyzed by the UDP-Glucose-Dependent Glycosyltransferase UGT71E5: Intensification of the Synthesis of 15-Hydroxy Cinmethylin β-d-Glucoside

Jihye Jung, Hui Liu, Annika J. E. Borg and Bernd Nidetzky

J. Agric. Food Chem., 2023, 71, 13419
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UDP‐glucosyltransferases from UGT73 family catalyze 3‐O‐glucosylation of isosteroidal and steroidal alkaloids in Fritillaria unibracteata var. wabuensis

Jingjin Wang, Zikun Wang, Hsihua Wang, Mingxin Pai, Tingting Li, Hengyang Zhang, Bengui Ye, Lin Tang, Rao Fu and Yang Zhang

The Plant Journal, 2025, 121
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Structure‐Function Analysis of the S‐Glycosylation Reaction in the Biosynthesis of Lincosamide Antibiotics

Takahiro Mori, Xin Sun, Stanislav Kadlcik, Jiri Janata and Ikuro Abe

Angew Chem Int Ed, 2023, 62
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Comprehensive engineering of novel glycosyltransferase for efficient, donor-promiscuous, and regioselective glycosylation of flavonoids

Yang Lu, Lianghua Xie, Jiahong Xie, Gexin Liu, Jiaqi Fu, Luheng Zou, Qiu Lin, Yong Wang and Wei Chen

Sci. Adv., 2025, 11
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Restoration of glucose metabolic homeostasis for treating CNS diseases: mechanistic insights and potential clinical prospect

Yi-Yue Zhang, Xing-Yu Long, Bi-Feng Yao, Jing Tian, Jun Peng and Xiu-Ju Luo

Free Radical Biology and Medicine, 2025, 241, 411
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A α-L-rhamnosidase from Echinacea purpurea endophyte Simplicillium sinense EFF1 and its application in production of Calceorioside B

Yali Ban, Hongwang Yang, Jixuan Jiang, Chengbin Wang, Bo Lv and Yongjun Feng

International Journal of Biological Macromolecules, 2024, 270, 132090
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Regio-specific synthesis of flavonoid glucuronides using plant UDP-glucuronosyltransferase expressed in yeast

Mst Julia Sultana, Takuto Kurakawa, Miyu Nishikawa and Shinichi Ikushiro

Bioscience, Biotechnology, and Biochemistry, 2025, 89, 954
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Hybrid genome and enzyme characterization uncover novel glycosyltransferases associated with benzylisoquinoline alkaloid chemodiversity in lotus

Hedi Zhao, Xinyi Qi, Yan Liu, Zhuyin Chen, Yifan Wang, Jing Que, Yanyan Su, Ling Yuan, Gangqiang Dong, An Liu, Zhennan Wang and Sha Chen

Journal of Advanced Research, 2026
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Conserved Local Structural Motifs in Glycoside Hydrolase Families Facilitate the Discovery of Functional Enzymes

Yu-Peng Liang, Ya-Lan Zhao, Zhong-Wei Yin, Xiao-Wei Gong, Xiu-Lin Han and Meng-Liang Wen

J. Agric. Food Chem., 2025, 73, 11983
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β-Carotene alleviates substrate inhibition caused by asymmetric cooperativity

Jieren Liao, Umar F. Shahul Hameed, Timothy D. Hoffmann, Elisabeth Kurze, Guangxin Sun, Wieland Steinchen, Alessandro Nicoli, Antonella Di Pizio, Christina Kuttler, Chuankui Song, Dragana A. M. Catici, Farhah Assaad-Gerbert, Thomas Hoffmann, Stefan T. Arold and Wilfried G. Schwab

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Discovery and mechanistic exploration of promiscuous xylosyltransferase based on protein engineering

Huanyu Zhang, Yanfang Su, Wei Yuan, Yaping Bo, Weiyi Zhao, Qingzhi Gao, Jianjun Qiao, Guoqi Zhang, Jie Meng, Luqi Huang, Juan Wang, Wenyuan Gao and Lanping Guo

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Enzyme Machinery for Bacterial Glucoside Metabolism through a Conserved Non‐hydrolytic Pathway

Klara Kastner, Johannes Bitter, Martin Pfeiffer, Christoph Grininger, Gustav Oberdorfer, Tea Pavkov‐Keller, Hansjörg Weber and Bernd Nidetzky

Angew Chem Int Ed, 2024
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Association analysis of maize stem vascular bundle micro-characteristics with yield components based on micro-CT and identification of related genes

Yanru Wang, Ying Zhang, Guanmin Huang, Jinglu Wang, Lujia Lv, Shuaihao Zhao, Xianju Lu, Minggang Zhang, Minkun Guo, Changyu Zhang, Qingmei Men, Xinyu Guo and Chunjiang Zhao

Sci Rep, 2025, 15
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Glycosyltransferases: Pioneering roles in agriculture and medicine

Qian Liu, Fabin Yang, Yanan Zhang, Qingli Liu, Wenjian Ma and Ying Wang

Plant Science, 2025, 356, 112520
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Functional characterization of plant UGT93s producing prenylated phenolic glycosides

Hong‐Ye Li, Jian‐Lin Zou, Bao Nie, Zi‐Long Wang, Meng Zhang, Chun‐Xue Zhao, Yan‐Fang Yang, Xi‐Ran Zhang, Xin‐Yue Zhan, Li Wang and Min Ye

JIPB, 2026, 68, 1218
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Mining and Engineering the Di-O-glycosylation Pattern of UGT72B1 for the Highly Efficient O-Glycosylation of Endogenous Quercetin

Zhi Geng, Ting Zhao, Ke Li, Li-Ling Liang, Ming-Xuan Chen, Zhijing Zhou, Jun Dai, Zongjie Dai and Kai-Zhi Jia

J. Agric. Food Chem., 2024, 72, 25219
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Plant UGTs: Functional diversity, catalytic mechanisms and rational design for metabolic engineering

Ruijun Wang, Chang Wang and Jikun Du

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A new UDP-glycosyltransferase for rare ginsenoside biosynthesis from Gynostemma pentaphyllum (Thunb.)

Qiaoxiang Wu, Yangyang Chen, Mingxing Ye, Yuanping Chen, Xiaoxuan Yuan, Xiaofen Liu, Zehao Huang, Shaohua Xu, Wei Xu, Hua Li and Yaqian Feng

Carbohydrate Research, 2025, 558, 109703
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Promiscuous Yet Specific: A Methionine–Aromatic Interaction Drives the Reaction Scope of the Family 1 Glycosyltransferase GmUGT88E3 from Soybean

Ruben M. de Boer, Dan E. H. Hvid, Elisa Davail, Dovydas Vaitkus, Jens Ø. Duus, Ditte H. Welner and David Teze

Biochemistry, 2023, 62, 3343
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Unearthing “Sweet” Secrets: Recent Advances in Novel Actinomycetes-Derived Glycosides and Their Bioactivities

Haotian Wang, Meilin Zhu, Yixuan Zhang, Yajuan Cong, Lanying Li, Liang Zhu and Hao Liu

J. Agric. Food Chem., 2025, 73, 31700
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Identification and Functional Characterization of a Novel C-Glycosyltransferase from Euscaphis konishii Hayata and Its Role in C-Glycoside Biosynthesis

Wei Liu, Wang-ke Yang, Jia-li Liu, Guo-feng Wu, Wan-yi Liu, Guan-peng Huang, Chang-mei Chen, Shuang-quan Zou, Hua-qin He and Wei Huang

J. Agric. Food Chem., 2026
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