Chemopreventive effects of atractylenolide-III on mammary tumorigenesis via activation of the Nrf2/ARE pathway through autophagic degradation of Keap1

Fangyi Long, Pinghan Wang, Yu Ma, Xudong Zhang and Ting Wang

Biomedicine & Pharmacotherapy, 2024, 176, 116852
DOI: 10.1016/j.biopha.2024.116852

Hypoxia inducible factor-1α (HIF-1α) in breast cancer: The crosstalk with oncogenic and onco-suppressor factors in regulation of cancer hallmarks

Sepideh Mirzaei, Bijan Ranjbar, Saeed Hesami Tackallou and Amir Reza Aref

Pathology - Research and Practice, 2023, 248, 154676
DOI: 10.1016/j.prp.2023.154676

Bixin alleviates radiation-induced intestinal damage via inflammation regulation and barrier recovery

Han Byul Kim, Hyewon Kim, Su-Hyun Oh, Min-Ji Kang, Jung Hwan Park, Seung Bum Lee, Sehwan Shim, Hae-June Lee, Ki-Chun Yoo and Hyosun Jang

International Journal of Radiation Biology, 2025, 101, 720
DOI: 10.1080/09553002.2025.2505523

Modulation of carcinogenesis with selected GRAS nutraceuticals via Keap1‐Nrf2 signaling pathway

Bhagyalakshmi Nair, Jayaprakash K. Adithya, Gopika Chandrababu, P. K. Lakshmi, Joel Joy Koshy, Sreedharan Vilasini Manoj, D. B. Ambiliraj, Balachandran S. Vinod, Gautam Sethi and Lekshmi R. Nath

Phytotherapy Research, 2023, 37, 4398
DOI: 10.1002/ptr.7940

Mitigating Effect of Dietary Dioclea reflexa (Hook F) Seed Inclusion in Experimental Colon Carcinogenesis

Uju Dorathy Iliemene-Ejike, Sunday Ene-Ojo Atawodi and Changmou Xu

Journal of Food Biochemistry, 2023, 2023, 1
DOI: 10.1155/2023/2823143

Deciphering the roles of aryl hydrocarbon receptor (AHR) in regulating carcinogenesis

Zhi Xiong Chong, Chean Yeah Yong, Alan Han Kiat Ong, Swee Keong Yeap and Wan Yong Ho

Toxicology, 2023, 495, 153596
DOI: 10.1016/j.tox.2023.153596

Hollow Spherical Curcumin Nanomicelles CUR@PLA@PF127: A New Trial on Breast Cancer Cells

Fatma S. El-Banna, Nemany A. N. Hanafy, Magdy E. Mahfouz and Maged El-Kemary

Biotechnol Bioproc E, 2023, 28, 842
DOI: 10.1007/s12257-023-0075-7

Activation of Nrf2 pathway as a protective mechanism against oxidative stress-induced diseases: Potential of astaxanthin

Osman N. Kanwugu and Tatiana V. Glukhareva

Archives of Biochemistry and Biophysics, 2023, 741, 109601
DOI: 10.1016/j.abb.2023.109601

Association of serum carotenoids and SII among general people, based on NHANES 2001–2006

Shao-Hua Yan, Wenqing Nai, LuShan Peng and Junpu Wang

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-94594-x

The Role of Nrf2/sMAF Signalling in Retina Ageing and Retinal Diseases

Jialing Zhang, Ting Zhang, Shaoxue Zeng, Xinyuan Zhang, Fanfan Zhou, Mark C. Gillies and Ling Zhu

Biomedicines, 2023, 11, 1512
DOI: 10.3390/biomedicines11061512

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

Vy Ngo and Martin L. Duennwald

Antioxidants, 2022, 11, 2345
DOI: 10.3390/antiox11122345

Treatment strategies targeting the phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin pathway against triple-negative breast cancer

Chun-Xiao Ni, Jia-Ju Xu, Yu Pang and Jia-Ju Xu

World J Clin Oncol, 2025, 16
DOI: 10.5306/wjco.v16.i5.104623

Antioxidant Activities of Plant Extracts (Ammannia multiflora, Ammannia coccinea, and Salix gracilistyla) Activate the Nrf2/HO-1 Signaling Pathway

Jayasingha Arachchige Chathuranga Chanaka Jayasingha, Yung Hyun Choi, Chang-Hee Kang, Mi-Hwa Lee, Moon-Soo Heo and Gi-Young Kim

Applied Sciences, 2023, 13, 6701
DOI: 10.3390/app13116701

Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol

Sumio Hayakawa, Tomokazu Ohishi, Yumiko Oishi, Mamoru Isemura and Noriyuki Miyoshi

Antioxidants, 2022, 11, 2352
DOI: 10.3390/antiox11122352

Kaempferol targets Src to exert its chemopreventive effects on mammary tumorigenesis via regulation of the PI3K/AKT pathway

Pinghan Wang, Yu Ma, Xiaohui Rao, Qianwen Luo, Xiao Xiao, Ting Wang and Fangyi Long

Phytomedicine, 2025, 141, 156701
DOI: 10.1016/j.phymed.2025.156701

Nrf2/Keap1/ARE regulation by plant secondary metabolites: a new horizon in brain tumor management

Saikat Dewanjee, Hiranmoy Bhattacharya, Chiranjib Bhattacharyya, Pratik Chakraborty, Joshua Fleishman, Athanasios Alexiou, Marios Papadakis and Saurabh Kumar Jha

Cell Commun Signal, 2024, 22
DOI: 10.1186/s12964-024-01878-2

Pharmacodynamics (PD), Pharmacokinetics (PK) and PK-PD Modeling of NRF2 Activating Dietary Phytochemicals in Cancer Prevention and in Health

Ahmad Shannar, Pochung Jordan Chou, Rebecca Peter, Parv Dushyant Dave, Komal Patel, Yuxin Pan, Jiawei Xu, Md Shahid Sarwar and Ah-Ng Kong

Curr. Pharmacol. Rep., 2024, 11
DOI: 10.1007/s40495-024-00388-6

Milk-derived exosomes in breast cancer therapy: Mechanisms and therapeutic potential

Deju Zhang, Shunjia Xing, Chengyuan Wang, Xinyao Wang, Yaqi Rong, Yiming Gan, Xuanyu Yang and Ni Xie

Food Bioscience, 2025, 74, 107953
DOI: 10.1016/j.fbio.2025.107953

Interplay between Nrf2 and ROS in regulating epithelial-mesenchymal transition: implications for cancer metastasis and therapy

Yi Xu, Shuning Hu, Rui Chen, Sheng Xu, Guangyang Yu and Lili Ji

Mol Biol Rep, 2025, 52
DOI: 10.1007/s11033-025-10731-9

Bioactive profiles and antimicrobial efficacy of common vegetable extracts: A review

Chinmaya Kumar Swain, Madhusmita Pradhan, Pravu Kalyan Mohanty, Kiran Kumar Mohapatra, Manasi Beria and Santanu Mohanty

Pharmacological Research - Natural Products, 2026, 10, 100592
DOI: 10.1016/j.prenap.2026.100592

Prognostic Potential of the NRF2 Transcription Factor in Canine Mammary Neoplasms

Vitor de Moraes Pina de Carvalho, Anna Hielm-Björkman, Karine Araújo Damasceno, Thanielle Novaes Fontes, Carlos Humberto da Costa Vieira-Filho, Simone Nunes, Diego Carlos dos Reis, Robin Moore, Stella Maria Barrouin-Melo, Geovanni Dantas Cassali and Alessandra Estrela-Lima

Cancers, 2026, 18, 1107
DOI: 10.3390/cancers18071107

Therapeutic Effects of Natural Products in the Treatment of Chronic Diseases: The Role in Regulating KEAP1–NRF2 Pathway

Yaling Li, Xijia Wang, Shuyue Li, Lei Wang, Ningning Ding, Yali She and Changtian Li

Am. J. Chin. Med., 2025, 53, 67
DOI: 10.1142/S0192415X25500041

Mechanistic role of Nrf2 modulators in lipid peroxidation: a perspective towards carcinogenesis

Anju Singh, Ritushree Kukreti, Luciano Saso and Shrikant Kukreti

Explor Med, 2025, 6
DOI: 10.37349/emed.2025.1001372

Induction of apoptosis by ethanol extract of sapodilla leaf in HGT-1 cells involved caspase-independent signal transduction pathway and activation of Nrf2/HO-1

Bee Ling Tan and Lee Chin Chan

Front. Pharmacol., 2026, 17
DOI: 10.3389/fphar.2026.1803513

The Multi-Faceted Consequences of NRF2 Activation throughout Carcinogenesis

Christopher J. Occhiuto, Jessica A. Moerland, Ana S. Leal, Kathleen A. Gallo and Karen T. Liby

Molecules and Cells, 2023, 46, 176
DOI: 10.14348/molcells.2023.2191

The Regulatory Effect of Phytochemicals on Chronic Diseases by Targeting Nrf2-ARE Signaling Pathway

Wen-Jiang He, Cheng-Hao Lv, Zhong Chen, Meng Shi, Chao-Xi Zeng, De-Xing Hou and Si Qin

Antioxidants, 2023, 12, 236
DOI: 10.3390/antiox12020236