Photoredox catalyzed synthesis of β-trifluoromethyl β-aminoketones from N-trifluoroethyl hydroxylamine reagent and silyl enol ethers

Yuxi Feng, Shuai Liu, Weidong Meng and Yangen Huang

Org. Biomol. Chem., 2025, 23, 10929
DOI: 10.1039/D5OB01591J

Photocatalysed C–H amidation of indoles enabled by tert-butyl alkyl((perfluoropyridin-4-yl)oxy)carbamate

Ke-yi Deng, Zhi-wei Wang, Zhen-zhen Xie, Jun-tao He, Jian-ping Guan, Kai Chen, Hao-yue Xiang and Hua Yang

Chem. Commun., 2023, 59, 11401
DOI: 10.1039/D3CC03532H

Photoredox-catalyzed allylation of C(sp3)–H bonds in N-trifluoroethyl hydroxylamines or hydroxamides via hydrogen atom transfer

Jia-Yin Wang, Jin-Long Dai, Tao Wang, Ming-Xian Zhang, Hong-Kai Sha and Shenghu Yan

Org. Biomol. Chem., 2025, 23, 10051
DOI: 10.1039/D5OB01288K

Photocatalytic stereoselective synthesis of amido-substituted (E)-α-trifluoromethyl allylamines via Heck-type alkylation

Lingli Liu, Yangian Cheng, Changduo Pan and Jin-Tao Yu

Org. Biomol. Chem., 2025, 23, 2120
DOI: 10.1039/D4OB02102A

Review and Theoretical Analysis of Fluorinated Radicals in Direct CAr−H Functionalization of (Hetero)arenes

Anthony J. Fernandes, Rahul Giri, Kendall N. Houk and Dmitry Katayev

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202318377

Visible-Light-Induced Defluorinative α-C(sp3)–H Alkylation for the Synthesis of gem-Difluoroallylated α-Trifluoromethylamines

Bingran Chen, Qinlin Chen, Yang Liu, Jinxiu Chen, Xi Zhou, Haifeng Wang, Qiongjiao Yan, Wei Wang, Zeyu Cai and Fen-Er Chen

Org. Lett., 2023, 25, 9124
DOI: 10.1021/acs.orglett.3c03523

2‐Aminoindoles and 2‐Iminoindolines as Viable Precursors of Indole‐Fused Nitrogenated Polyheterocycles

Alessandro Palmieri and Marino Petrini

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.202401237

Nickel−Metallaphotoredox-Catalyzed Radical Cross-Couplings to Access α-Aryl-α-trifluoromethyl Amines Under Flow Conditions

Md Nuruzzaman Khan, Jia-Yi Shou and Feng-Ling Qing

J. Org. Chem., 2026, 91, 4487
DOI: 10.1021/acs.joc.6c00353

Visible-Light-Driven C,N-Selective Heteroarylation of N-Fluoroalkyl Hydroxylamine Reagents with Quinoxalin-2(1H)-ones

Yang Liu, Tongyao Zhou, Liangming Xuan, Yanchun Lin, Fuqi Li, Haifeng Wang, Jian Lyu, Qiongjiao Yan, Hui Zhou, Wei Wang and Fen-Er Chen

Org. Lett., 2023, 25, 8693
DOI: 10.1021/acs.orglett.3c03594

Visible-Light-Induced Radical Cascade Cross-Coupling via C(sp3)–H Activation and C–N/N–O Cleavage: Feasible Access to Methylenebisamide Derivatives

Jinglan Lei, Min Li, Qingqing Zhang, Shuyang Liu, Haifang Li, Lei Shi, Wen-Feng Jiang, Chunying Duan and Yunhe Jin

Org. Lett., 2023, 25, 2300
DOI: 10.1021/acs.orglett.3c00646

Divergent Synthesis of 3‐Trifluoroethyl Benzofurans Through Rh‐Catalyzed CC Bond Activation Coupled with Transfer Hydrogenation

Qi Wang, Qi Tang, Li‐Juan Zhang, Bi‐Qin Wang, Ping Hu, Hai‐Liang Ni and Feijie Song

Adv Synth Catal, 2026, 368
DOI: 10.1002/adsc.9608

N−H Trifluoroethylation of Indoles and other Aromatic N‐Heterocycles with CF3CHCl2 by Copper‐Mediated Cross‐Coupling Reaction

Zhen Deng, Liu‐Yan Qiu, Jie Chen, Hui Zhang, Weiguo Cao and Xiao‐Jun Tang

Adv Synth Catal, 2023, 365, 693
DOI: 10.1002/adsc.202201135

Visible-Light-Driven Tandem Cyclization of o-Hydroxyaryl Enaminones: Access to 3-(α-Arylsulfonamido)trifluoroethyl Chromones

Jinwei Yuan, Qiyang Liu, Xuanlin Liu, Da Wang, Meng Yan, Xianghui Meng, Ji Ma and Lingbo Qu

J. Org. Chem., 2025, 90, 6031
DOI: 10.1021/acs.joc.5c00424

Nitrogen-Based Organofluorine Functional Molecules: Synthesis and Applications

Shuai Liu, Jun Zhou, Lu Yu, Yingle Liu, Yangen Huang, Yao Ouyang, Guo-Kai Liu, Xiu-Hua Xu and Norio Shibata

Chem. Rev., 2025, 125, 4603
DOI: 10.1021/acs.chemrev.4c00661

Direct Assembly of Privileged α-CF3 Allylamines via Photoinduced Pd-Catalyzed C–H Aminoalkylation of Alkenes

Jie Zhou, Lu-Ping Hu, Xuan Fan, Peng-Hui Shen, Jun Xu and Hua-Jian Xu

Org. Lett., 2025, 27, 13380
DOI: 10.1021/acs.orglett.5c04528

Review and Theoretical Analysis of Fluorinated Radicals in Direct CAr−H Functionalization of (Hetero)arenes

Anthony J. Fernandes, Rahul Giri, Kendall N. Houk and Dmitry Katayev

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202318377

Organophotoredox-Driven Three-Component Synthesis of β-Trifluoromethyl β-Amino Ketones

Marta Gil-Ordóñez, Albert Gallego-Gamo, Pau Sarró, Roser Pleixats, Carolina Gimbert-Suriñach, Adelina Vallribera and Albert Granados

J. Org. Chem., 2025, 90, 2500
DOI: 10.1021/acs.joc.4c03142

Recent advances in C(sp³)–H functionalization via nitrogen-centered radical-mediated 1,2-hydrogen atom transfer

Yangbin Zhu, Lifang Jiang, Binbin Zhang and Fangxuan Fan

Sci. Sin.-Chim, 2026, 56, 371
DOI: 10.1360/SSC-2025-0280