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Poly(sarcosine)-block-oligo(l-tryptophan) Copolymers as Noncovalent Inhibitors of Protein Aggregation

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Enhanced and Prolonged Immunogenicity in Mice of Thermally Stabilized Fatty Acid-Conjugated Vaccine Antigen

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The Application of Nano Drug Delivery Systems in Female Upper Genital Tract Disorders

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Amphiphilic albumin-based nanoparticles designed for the efficient delivery of taxanes

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Protein‐based Nanoparticles: From Drug Delivery to Imaging, Nanocatalysis and Protein Therapy

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Quantitative Laser Diffraction Mediated Detection of Submicron and Subvisible Aggregates (100 nm–10 μm) in Biotherapeutics: Need for Regulatory Attention To this Neglected Particle Size Range

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The role of hydrophilic linkers in next-generation antibody-drug conjugates

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Enrichment strategy and initial characterization of heterodimers enriched from a co-formulated cocktail of therapeutic antibodies against SARS-COV-2

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Influence of pneumatic transportation on the stability of monoclonal antibodies

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Circular dichroism spectroscopy in protein engineering and pharmaceutical development: Applications in structural characterization and quality assessment

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Machine Learning-Enabled Image Comparability Assessment for Flow Imaging Microscopy Across Platforms

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Pharmaceuticals, 2026, 19, 107
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A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years

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Detailed atomistic investigation of aggregation and interaction of teriparatide in aqueous media

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Conjugation Chemistry Markedly Impacts Toxicity and Biodistribution of Targeted Nanoparticles, Mediated by Complement Activation

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Preventing Protein Self‐Association Through Strategic Covalent Modification

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Characterizing Silicone Oil-Induced Protein Aggregation with Stimulated Raman Scattering Imaging

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Best Practices for Submission of NMR Data to Support Higher Order Structure Assessment of Generic Peptide Drugs

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Immunogenicity of Therapeutic Antibodies Used for Inflammatory Bowel Disease: Treatment and Clinical Considerations

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The characteristic changes of bovine casein hydrolyzed by Bacillus velezensis DB219 and its mutant E361I milk-clotting enzyme

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Avidity-Based Detection and Quantification of Igg Aggregates Using a Nanoplasmonic Fiber Optical Biosensor System

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Effect of Carrier Protein Size on Hapten Immunogenicity and Antibody Affinity in Mice

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Structural morphology of peptide nanofibrils dictates viral capture and cellular uptake in gene therapy applications

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Machine-guided dual-objective protein engineering for deimmunization and therapeutic functions

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Recent research on the druggability properties of chemical modification of endogenous substances

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Strategies to Overcome Undesired Physicochemical Changes in Particle Engineering for Inhalation

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A Deletion Variant of Human Factor VIII Displaying Low Immunogenicity in a Murine Model of Hemophilia A

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Harnessing the potential of 2-methyl imidazolium dihydrogen phosphate as a protein stabilizer: Assessing its toxicity and impact on aggregation, structural integrity, and functional efficacy of monoclonal antibodies

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A proteome scale study reveals how plastic surfaces and agitation promote protein aggregation

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Anti-Drug Antibody Response to Therapeutic Antibodies and Potential Mitigation Strategies

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Optical imaging and spectroscopic characterization of subvisible particles in protein therapeutics

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Immunological Considerations of Polysorbate as an Excipient in Botulinum Neurotoxin Type A Formulations: A Narrative Review

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Nanoplasmonic Avidity-Based Detection and Quantification of IgG Aggregates

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Recent advances in generative biology for biotherapeutic discovery

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Methionine sulfoxide reductases gene deletion strains of Salmonella Typhimurium accumulate higher order of protein oligomers, show impaired intraphagocytic survival and defective colonization in poultry

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Dynamic Light Scattering for Assessing Aggregation in [177Lu]Lu-DOTA-Trastuzumab: A Quality Control Approach for Radioimmunotherapy

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Automated optimisation of solubility and conformational stability of antibodies and proteins

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Purification and characterization of soluble recombinant Crimean-Congo hemorrhagic fever virus glycoprotein Gc expressed in mammalian 293F cells

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Unique structure of ozoralizumab, a trivalent anti-TNFα NANOBODY® compound, offers the potential advantage of mitigating the risk of immune complex-induced inflammation

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Impact of Monoclonal Antibody Aggregates on Effector Function Characterization

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Characterization of Conformational Instability of Monoclonal Antibodies During Chromatographic Purification

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Highly variable aggregation and glycosylation profiles and their roles in immunogenicity to protein-based therapeutics

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Analytical control strategy for biologics. Part I: Foundations

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Glycosylation shapes the efficacy and safety of diverse protein, gene and cell therapies

Frances Rocamora, Angelo G. Peralta, Seunghyeon Shin, James Sorrentino, Mina Ying Min Wu, Eric A. Toth, Thomas R. Fuerst and Nathan E. Lewis

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Impact of Urea on Monoclonal Antibodies: Multiple Destabilization and Aggregation Effects for Therapeutic Immunoglobulin G Proteins

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ACS Omega, 2024, 9, 5517
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Comprehensive physicochemical and functional analysis of pembrolizumab based on controlled degradation studies: Impact on antigen–antibody binding

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European Journal of Pharmaceutics and Biopharmaceutics, 2024, 194, 131
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Electrochemical Protein-based Bioanalytical Devices for Drug Analysis

Caroline G. Sanz and Victor C. Diculescu

CTMC, 2023, 23, 1448
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Unraveling the Effects of Filtration, Process Interruptions, and Post-Process Agitation on Protein Aggregation

Christina Winter, Anna Springer, Jean-Loup Descamps, Joris Hoefinghoff, Salehi Mohammad-Sadegh, Amrit Paudel and Milica Stankovic-Brandl

AAPS PharmSciTech, 2025, 26
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Comparative Analysis of Protein Surface Hydrophobicity Maps Determined by Sparse Sampling INDUS and Spatial Aggregation Propensity

Imee Sinha, Shekhar Garde and Steven M. Cramer

J. Phys. Chem. B, 2023, 127, 10304
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Shear flow during reciprocal shaking does not disrupt protein films at the solid–liquid interface

Tetsuo Torisu, Nana Iwamoto, Rio Okada, Naohiro Degura, Susumu Uchiyama, Nozomu Osaka, Shota Kukimoto, Daiki Watanabe, Yutaro Motoori and Susumu Goto

International Journal of Pharmaceutics, 2026, 694, 126732
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Self-assembled nanonization of fatty acid-conjugated vaccine antigen for enhanced thermal stability

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Concentration‐dependent dimerization of staphylokinase variants with engineered surface charges

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Molecular Bases of Protein Antigenicity and Determinants of Immunogenicity, Anergy, and Mitogenicity

David Pedroza-Escobar, Irais Castillo-Maldonado, Tania González-Cortés, Dealmy Delgadillo-Guzmán, Pablo Ruíz-Flores, Jorge Haro Santa Cruz, Perla-Karina Espino-Silva, Erika Flores-Loyola, Agustina Ramirez-Moreno, Joaquín Avalos-Soto, Miguel-Ángel Téllez-López, Sergio-Everardo Velázquez-Gauna, Rubén García-Garza, Rubén Daniel Arellano Pérez Vertti and Cristian Torres-León

PPL, 2023, 30, 719
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Current PAT Landscape in the Downstream Processing of Biopharmaceuticals

Pavithra Sathiyapriyan, Shatanik Mukherjee, Thomas Vogel, Lars‐Oliver Essen, David Boerema, Martin Vey and Uwe Kalina

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Neurodegeneration Through the Lens of Bioinformatics Approaches: Computational Mechanisms of Protein Misfolding

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Machine Learning for Predicting the Drug-to-Antibody Ratio (DAR) in the Synthesis of Antibody–Drug Conjugates (ADCs)

Lorenzo Angiolini, Fabrizio Manetti, Ottavia Spiga, Andrea Tafi, Anna Visibelli and Elena Petricci

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Advances in nanobody multimerization and multispecificity: from in vivo assembly to in vitro production

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Protein‐basierte Nanopartikel: Von Wirkstofftransport zu Bildgebung, Nanokatalyse und Proteintherapie

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rhGALNS Enzyme Stability in Physiological Buffers: Implications for Sustained Release

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Exploring Protein Aggregation in Biological Products: From Mechanistic Understanding to Practical Solutions

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AAPS PharmSciTech, 2025, 26
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A tacrolimus-eluting nerve guidance conduit enhances regeneration in a critical-sized peripheral nerve injury rat model

Azur Azapagic, Jayant Agarwal, Bruce Gale, Jill Shea, Susan Wojtalewicz and Himanshu Sant

Biomed Microdevices, 2024, 26
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Unveiling the Effects of Light Exposure on Bevacizumab Stability in Clinical Settings

Elisabetta De Diana, Chiara Sottoriva, Giorgia Zorzetto, Giovanna Crivellaro, Nicoletta Rigamonti, Marina Coppola, Claudia Cecilia Vera, Claudio Darío Borsarelli, Benedetta Campara, Luca Menilli, Ilaria Battisti, Giulia Rocca, Giorgio Arrigoni and Giorgia Miolo

International Journal of Pharmaceutics, 2026, 691, 126578
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Benchmarking Protein Nanoparticles for Drug Delivery and Clinical Translation

Han Sol Lee, Suwon Choo, Mansingh Chaudhary, Ju Hee Park, Juhwan Chang, Yejun Byun, Ki‐Taek Kim and Jae‐Young Lee

Small Methods, 2026, 10
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US FDA-approved therapeutic antibodies with high-concentration formulation: summaries and perspectives

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Live Monitoring of Nanoparticle Aggregation and Sedimentation in Biological Fluids Using X-ray Photon Correlation Spectroscopy

Linfeng Wei, Chenhui Cui, Zimu Zhou, Songlin Li, Hanyu Song, Feng Tian, Xiuhong Li, Yihui Xu, Zhi Guo, Renzhong Tai and Huaidong Jiang

ACS Appl. Mater. Interfaces, 2025, 17, 45429
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Human ADA2-specific IgY antibodies from hen eggs with tolerance to human IgG

E. Yu. Sarkisyan, H. A. Haroutyunyan and Ye. G. Sargisova

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Redirecting the JAK‐STAT signal blocks the SARS‐CoV‐2 replication

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Journal of Medical Virology, 2023, 95
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Unraveling the Microscopic Mechanism of Molecular Ion Interaction with Monoclonal Antibodies: Impact on Protein Aggregation

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Mol. Pharmaceutics, 2024, 21, 1285
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“Biophysical and colloidal properties govern anti-drug antibody generation: A case study using the tumoricidal murine-derived monoclonal antibody 4713”

Sanjida Yesmin, M. Monirul Islam, Md. Din Islam, Hiromichi Tsurui, Tomonori Saotome, Shuji Matsuoka and Yutaka Kuroda

International Journal of Biological Macromolecules, 2026, 355, 151430
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Nano-Analytical Techniques in Pharmaceutical Analysis

C. Hima Bindu, T. Farmaan, K. Aparna, M. Sadan and T Reshma

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tANCHOR fast and cost-effective cell-based immunization approach with focus on the receptor-binding domain of SARS-CoV-2

Hubert Bernauer, Anja Schlör, Josef Maier, Norbert Bannert, Katja Hanack and Daniel Ivanusic

Biology Methods and Protocols, 2023, 8
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Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer’s disease

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Alz Res Therapy, 2023, 15
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Strategy to mitigate aggregation during Protein A chromatography and low pH virus inactivation for a nivolumab biosimilar candidate

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Journal of Chromatography A, 2025, 1743, 465698
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Aggregation Issues in Radioactive Copper-Labeled Antibodies

Muhammad Zeeshan, Huu Bao Nguyen and Jeongsoo Yoo

Nucl Med Mol Imaging, 2025
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Cosolute effects reveal the nature of weak forces governing GLP-1 oligomer stability

Anyah Settle, Rahul Mishra, Ramesh Kumar Shanmugam, Viv Lindo, Nathan BP. Adams, Thomas A. Jowitt, Tuck Seng Wong and Barbara Ciani

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Protein distribution in SBA-15: Insights from thermal decomposition and advanced imaging

Kristoffer Vorm, Chrysoula Stathaki, Pedro L. Oseliero Filho, Hery Mitsutake, Tereza S. Martins, Nikolay Kardjilov, Luis C. Cides-da-Silva, Márcia C.A. Fantini, François B. Lauze and Heloisa N. Bordallo

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Investigating Local Sequence‐Structural Attributes of Amyloidogenic Light Chain Variable Domains

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Proteins, 2025, 93, 1451
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Relationships between surface tensiometry properties and fluorescence intensity of dark and light exposed monoclonal antibody Nivolumab/Opdivo® by using the contact angle method: A pilot study

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Transformative protein scaffold designs for dual-modality cancer applications: Advances in therapeutic delivery and molecular imaging of tumor microenvironments

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International Journal of Biological Macromolecules, 2025, 318, 144881
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Stoichiometric Antibody–Polymer–Drug Conjugate for Effective Low-Dose Treatment of Breast Cancer

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