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Poly(sarcosine)-block-oligo(l-tryptophan) Copolymers as Noncovalent Inhibitors of Protein Aggregation

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Enhanced and Prolonged Immunogenicity in Mice of Thermally Stabilized Fatty Acid-Conjugated Vaccine Antigen

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Quantitative Laser Diffraction Mediated Detection of Submicron and Subvisible Aggregates (100 nm–10 μm) in Biotherapeutics: Need for Regulatory Attention To this Neglected Particle Size Range

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The role of hydrophilic linkers in next-generation antibody-drug conjugates

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Enrichment strategy and initial characterization of heterodimers enriched from a co-formulated cocktail of therapeutic antibodies against SARS-COV-2

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Influence of pneumatic transportation on the stability of monoclonal antibodies

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Circular dichroism spectroscopy in protein engineering and pharmaceutical development: Applications in structural characterization and quality assessment

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Machine Learning-Enabled Image Comparability Assessment for Flow Imaging Microscopy Across Platforms

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A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years

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Detailed atomistic investigation of aggregation and interaction of teriparatide in aqueous media

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Conjugation Chemistry Markedly Impacts Toxicity and Biodistribution of Targeted Nanoparticles, Mediated by Complement Activation

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Preventing Protein Self‐Association Through Strategic Covalent Modification

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From discovery to therapeutic development of monoclonal antibodies

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Characterizing Silicone Oil-Induced Protein Aggregation with Stimulated Raman Scattering Imaging

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Thermoresponsive injectable sol-gel depot systems for long-acting antidiabetic drug delivery: a critical analysis of polymer chemistry, rheological engineering, and translational challenges

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Best Practices for Submission of NMR Data to Support Higher Order Structure Assessment of Generic Peptide Drugs

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Immunogenicity of Therapeutic Antibodies Used for Inflammatory Bowel Disease: Treatment and Clinical Considerations

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The characteristic changes of bovine casein hydrolyzed by Bacillus velezensis DB219 and its mutant E361I milk-clotting enzyme

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Avidity-Based Detection and Quantification of Igg Aggregates Using a Nanoplasmonic Fiber Optical Biosensor System

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Effect of Carrier Protein Size on Hapten Immunogenicity and Antibody Affinity in Mice

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Structural morphology of peptide nanofibrils dictates viral capture and cellular uptake in gene therapy applications

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Machine-guided dual-objective protein engineering for deimmunization and therapeutic functions

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Recent research on the druggability properties of chemical modification of endogenous substances

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Strategies to Overcome Undesired Physicochemical Changes in Particle Engineering for Inhalation

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A Deletion Variant of Human Factor VIII Displaying Low Immunogenicity in a Murine Model of Hemophilia A

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Harnessing the potential of 2-methyl imidazolium dihydrogen phosphate as a protein stabilizer: Assessing its toxicity and impact on aggregation, structural integrity, and functional efficacy of monoclonal antibodies

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A proteome scale study reveals how plastic surfaces and agitation promote protein aggregation

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Anti-Drug Antibody Response to Therapeutic Antibodies and Potential Mitigation Strategies

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Optical imaging and spectroscopic characterization of subvisible particles in protein therapeutics

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Immunological Considerations of Polysorbate as an Excipient in Botulinum Neurotoxin Type A Formulations: A Narrative Review

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Nanoplasmonic Avidity-Based Detection and Quantification of IgG Aggregates

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Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

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Recent advances in generative biology for biotherapeutic discovery

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Methionine sulfoxide reductases gene deletion strains of Salmonella Typhimurium accumulate higher order of protein oligomers, show impaired intraphagocytic survival and defective colonization in poultry

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Real‐world incidence and clinical characteristics of intraocular inflammation following intravitreal faricimab therapy: A safety study

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Acta Ophthalmologica, 2026
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Dynamic Light Scattering for Assessing Aggregation in [177Lu]Lu-DOTA-Trastuzumab: A Quality Control Approach for Radioimmunotherapy

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Automated optimisation of solubility and conformational stability of antibodies and proteins

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Purification and characterization of soluble recombinant Crimean-Congo hemorrhagic fever virus glycoprotein Gc expressed in mammalian 293F cells

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Unique structure of ozoralizumab, a trivalent anti-TNFα NANOBODY® compound, offers the potential advantage of mitigating the risk of immune complex-induced inflammation

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Impact of Monoclonal Antibody Aggregates on Effector Function Characterization

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Characterization of Conformational Instability of Monoclonal Antibodies During Chromatographic Purification

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Highly variable aggregation and glycosylation profiles and their roles in immunogenicity to protein-based therapeutics

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Analytical control strategy for biologics. Part I: Foundations

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Glycosylation shapes the efficacy and safety of diverse protein, gene and cell therapies

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Impact of Urea on Monoclonal Antibodies: Multiple Destabilization and Aggregation Effects for Therapeutic Immunoglobulin G Proteins

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Comprehensive physicochemical and functional analysis of pembrolizumab based on controlled degradation studies: Impact on antigen–antibody binding

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Electrochemical Protein-based Bioanalytical Devices for Drug Analysis

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Unraveling the Effects of Filtration, Process Interruptions, and Post-Process Agitation on Protein Aggregation

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Comparative Analysis of Protein Surface Hydrophobicity Maps Determined by Sparse Sampling INDUS and Spatial Aggregation Propensity

Imee Sinha, Shekhar Garde and Steven M. Cramer

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Shear flow during reciprocal shaking does not disrupt protein films at the solid–liquid interface

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Self-assembled nanonization of fatty acid-conjugated vaccine antigen for enhanced thermal stability

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Concentration‐dependent dimerization of staphylokinase variants with engineered surface charges

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Molecular Bases of Protein Antigenicity and Determinants of Immunogenicity, Anergy, and Mitogenicity

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Current PAT Landscape in the Downstream Processing of Biopharmaceuticals

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Analytical Science Advances, 2025, 6
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Neurodegeneration Through the Lens of Bioinformatics Approaches: Computational Mechanisms of Protein Misfolding

Mubashir Hassan, Saba Shahzadi, Ahmed A. Moustafa and Andrzej Kloczkowski

IJMS, 2025, 26, 11021
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Machine Learning for Predicting the Drug-to-Antibody Ratio (DAR) in the Synthesis of Antibody–Drug Conjugates (ADCs)

Lorenzo Angiolini, Fabrizio Manetti, Ottavia Spiga, Andrea Tafi, Anna Visibelli and Elena Petricci

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Advances in nanobody multimerization and multispecificity: from in vivo assembly to in vitro production

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Protein‐basierte Nanopartikel: Von Wirkstofftransport zu Bildgebung, Nanokatalyse und Proteintherapie

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rhGALNS Enzyme Stability in Physiological Buffers: Implications for Sustained Release

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Exploring Protein Aggregation in Biological Products: From Mechanistic Understanding to Practical Solutions

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A tacrolimus-eluting nerve guidance conduit enhances regeneration in a critical-sized peripheral nerve injury rat model

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Biomed Microdevices, 2024, 26
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Unveiling the Effects of Light Exposure on Bevacizumab Stability in Clinical Settings

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International Journal of Pharmaceutics, 2026, 691, 126578
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Novel approach for vaccine delivery using mRNA lipid nanoparticles for in vivo production of monoclonal antibodies

Kenneth Lundstrom

Molecular Therapy Nucleic Acids, 2026, 37, 102940
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Benchmarking Protein Nanoparticles for Drug Delivery and Clinical Translation

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Small Methods, 2026, 10
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US FDA-approved therapeutic antibodies with high-concentration formulation: summaries and perspectives

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Live Monitoring of Nanoparticle Aggregation and Sedimentation in Biological Fluids Using X-ray Photon Correlation Spectroscopy

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Human ADA2-specific IgY antibodies from hen eggs with tolerance to human IgG

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Redirecting the JAK‐STAT signal blocks the SARS‐CoV‐2 replication

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Unraveling the Microscopic Mechanism of Molecular Ion Interaction with Monoclonal Antibodies: Impact on Protein Aggregation

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“Biophysical and colloidal properties govern anti-drug antibody generation: A case study using the tumoricidal murine-derived monoclonal antibody 4713”

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International Journal of Biological Macromolecules, 2026, 355, 151430
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Nano-Analytical Techniques in Pharmaceutical Analysis

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tANCHOR fast and cost-effective cell-based immunization approach with focus on the receptor-binding domain of SARS-CoV-2

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Biology Methods and Protocols, 2023, 8
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Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer’s disease

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Strategy to mitigate aggregation during Protein A chromatography and low pH virus inactivation for a nivolumab biosimilar candidate

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A novel, widespread impurity in mass-compounded tirzepatide/B12 products: potential patient safety implications

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Aggregation Issues in Radioactive Copper-Labeled Antibodies

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