Electrophilic aromatic substitution using fluorinated isoxazolines at the C5 position via C–F bond cleavage

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Regioselective cyclocondensations with thiobarbituric acid: spirocyclic and azocine products, X-ray characterization, and antioxidant evaluation

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Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams

Prasanta Das, Cord Carter, Gulrukh Shaheen and Ashton T. Hamme

RSC Adv., 2022, 12, 9628
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Recent advances on anticancer and antimicrobial activities of directly-fluorinated five-membered heterocycles and their benzo-fused systems

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Synthesis of novel chiral spiro-β-lactams from nitrile oxides and 6-(Z)-(benzoylmethylene)penicillanate: batch, microwave-induced and continuous flow methodologies

Américo J. S. Alves, João A. D. Silvestre and Teresa M. V. D. Pinho e Melo

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Recent progress in therapeutic applications of fluorinated five-membered heterocycles and their benzo-fused systems

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Synthesis and Cytotoxic Evaluation of Fluoro and Trifluoromethyl Substituents Containing Novel Naphthoquinone-Fused Podophyllotoxins

Nguyen Ha Thanh, Hoang Thi Phuong, Le Thi Tu Anh, Le Nhat Thuy Giang, Nguyen Thi Quynh Giang, Nguyen Tuan Anh, Dang Thi Tuyet Anh and Phan Van Kiem

Natural Product Communications, 2022, 17
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An Efficient One-pot Synthesis of Certain Stereoselective Spiro[pyrazole-4,5′-isoxazoline]-5-one Derivatives: In vitro Evaluation of Antitumor Activities, Molecular Docking and In silico ADME Predictions

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Chem. Res. Chin. Univ., 2022, 38, 1073
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Synthesis, Molecular Docking, and Cytotoxic Evaluation of Fluorinated Podophyllotoxin Derivatives

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Natural Product Communications, 2023, 18
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Regioselective synthesis of novel spiro-isoxazolines congeners as antimicrobial agents: in vitro and in-silico assessments

Rachid Bouzammit, Soumia Ait Assou, Mohammed Er-Rajy, Noura Aflak, Lahoucine Bahsis, Mohammed Chalkha, Mohammed El Hassouni, Mohammed Lachkar, Taibi Ben Hadda, Daryn Benson, Abdullah A. Alyousef, Mourad A. M. Aboul-Soud, John P. Giesy and Ghali Al Houari

Front. Chem., 2025, 13
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Synthesis of Novel N-Alkyl-3-mesityl-5-methyl-4,5-dihydro-isoxazole-5-carboxamide Molecules: In Vitro Antimicrobial, Antimalarial Evaluation, and In Silico Prediction Studies

Amit Chouhan, Sumit Kumar, Ajit Joshi and Satyanarayana Battula

Russ J Bioorg Chem, 2025, 51, 1262
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Design, synthesis and biological evaluation of 7–(5–((substituted – amino)-methyl)-thiophen–2–yl)-spiro-[chroman–2,4′–piperidin]–4–one hydrochloride analogues as anticancer agents

Surendar Chitti, Sravani Pulya, Adinarayana Nandikolla, Tarun Kumar Patel, Banoth Karan Kumar, Sankaranarayanan Murugesan, Balaram Ghosh and Kondapalli Venkata Gowri Chandra Sekhar

Bioorganic Chemistry, 2021, 112, 104865
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New Methods for the Synthesis of Spirocyclic Cephalosporin Analogues

Alan Zhao, Louise Horsfall and Alison Hulme

Molecules, 2021, 26, 6035
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Synthesis and Cytotoxic Evaluation of New Fluoro and Trifluoromethyl Substituents Containing Chromeno[2,3‐d]pyrimidines

Ha Thanh Nguyen, Ha Nguyen Van, Phuong Hoang Thi, Tuyet Anh Dang Thi, Giang Le‐Nhat‐Thuy, Quynh Giang Nguyen Thi, Anh Nguyen Tuan, Cham Ba Thi, Hung Tran Quang and Tuyen Van Nguyen

ChemistrySelect, 2023, 8
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Deciphering the cytotoxic and antioxidant potential of 3,5-disubstituted isoxazole-linked benzimidazolone derivatives

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Journal of Molecular Structure, 2025, 1320, 139683
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Construction of new quaternary carbon center of fluorinated isoxazolines at C5 position via C-F bond cleavage

Kazuyuki Sato, Kazuki Nakano, Takahiro Ueda, Yukine Kitamura, Yuna Tanaka, Yukiko Karuo, Atsushi Tarui, Kentaro Kawai and Masaaki Omote

Journal of Fluorine Chemistry, 2024, 279, 110335
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Synthesis of five-membered, CF3-containing lactones: structural and biological examinations

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Journal of Molecular Structure, 2026, 1360, 145422
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Assessment of anti-hyperglycemic and anti-hyperlipidemic effects of thiazolidine-2,4-dione derivatives in HFD-STZ diabetic animal model

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Synthesis, Antioxidant, and Antibacterial Activities of Two Novel Series of 3,5-Disubstituted Isoxazole Ether-Linked Isoxazolines and 3,5-Disubstituted Pyrazole Ether-Linked Isoxazolines Mediated by Chloramine-T

E. A. M. Saleh, S. Y. Kotian, A. M. Al Dawsari, I. Hassan, K. Husain, P. C. Abishad, K. Byrappa, R. S. S. AL Sharabi and K. M. L. Rai

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Review on the Synthesis of Bio-Active Spiro-Fused Heterocyclic Molecules

Geetika Patel, Ashok Raj Patel, Sameera Kheti, Parimal Kumar Sao, Gargee Rathore and Subhash Banerjee

COCAT, 2023, 10, 180
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Investigation of radiation protective features of azadispiro derivatives and their genotoxic potential with Ames/Salmonella test system

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Diastereoselective Synthesis of Spirocyclic Ether from ortho‐Carbonylarylacetylenols via Silver‐Catalyzed Cyclization under Acidic Conditions

Kanokwan Jaithum, Jumreang Tummatorn, Bundet Boekfa, Charnsak Thongsornkleeb, Kittipong Chainok and Somsak Ruchirawat

Adv Synth Catal, 2021, 363, 3812
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Structural, spectroscopic and computational studies of two new spirocompounds containing 2,3,4-trimethoxybenzyl group

Wulan Zeng, Xia Wang, Youwang Li, Xueao Li and Yuxing Zhang

Journal of Molecular Structure, 2022, 1269, 133806
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Theoretical and experimental study on a new spiro compound 3-(2-(2-hydroxyphenyl)hydrazono)-1,5-dioxaspiro[5.5]undecane-2,4-dione

Yunju Zhang, Xia Wang and Wulan Zeng

Struct Chem, 2026, 37, 247
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Synthesis, Structure, and Antiviral Activity of Camphene‐Based Spiroisoxazolines

Dmitry E. Shybanov, Yuri K. Grishin, Vitaly A. Roznyatovsky, Olga I. Yarovaya, Vladimir V. Zarubaev, Maria A. Niukalova, Angelica V. Garshinina, Nariman F. Salakhutdinov, Nikolai V. Zyk and Elena K. Beloglazkina

ChemistrySelect, 2025, 10
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