Customized materials-assisted microorganisms in tumor therapeutics

Qi-Wen Chen, Ji-Yan Qiao, Xin-Hua Liu, Cheng Zhang and Xian-Zheng Zhang

Chem. Soc. Rev., 2021, 50, 12576
DOI: 10.1039/D0CS01571G

Engineering bacterial surface interactions using DNA as a programmable material

Yuhan Kong, Qi Du, Juan Li and Hang Xing

Chem. Commun., 2022, 58, 3086
DOI: 10.1039/D1CC06138K

Engineered bacteria for augmentedin situtumor vaccination

Xinyuan Shen, Chaojie Zhu, Xutao Liu, Hanqi Zheng, Qing Wu, Jijin Xie, Hao Huang, Ziyan Liao, Jiaqi Shi, Kewang Nan, Junxia Wang, Xuming Mao, Zhen Gu and Hongjun Li

Biomater. Sci., 2023, 11, 1137
DOI: 10.1039/D2BM01593E

Promising dawn in tumor microenvironment therapy: engineering oral bacteria

Zifei Wang, Wansu Sun, Ruixue Hua, Yuanyin Wang, Yang Li and Hengguo Zhang

Int J Oral Sci, 2024, 16
DOI: 10.1038/s41368-024-00282-3

The Rise of AIE‐Peptide Systems: Design Principles, Multifunctional Applications, and Future Perspectives

Yang Qian Hou, Ben Zhong Tang and Dong Wang

Advanced Materials, 2026, 38
DOI: 10.1002/adma.202514134

Developing the Limosilactobacillus reuteri Chassis through an Endogenous Programmable Endonuclease-Based Genome Editing Tool

Qiujin Guo, Yiting Yan, Zhenting Zhang, Boya Xu, Hina lqbal Bangash, Xin Sui, Yalin Yang, Zhigang Zhou, Shumiao Zhao and Nan Peng

ACS Synth. Biol., 2023, 12, 3487
DOI: 10.1021/acssynbio.3c00450

Hybrid Bacteria System with Nanomaterials for Tumor Therapy

Qinyi Zhang, Xiaotu Ma and Xiao Zhao

Advanced NanoBiomed Research, 2023, 3
DOI: 10.1002/anbr.202300003

Harnessing the gut microbiome to enhance cancer immunotherapy: Current advances and future directions in microbiota‐based therapeutic strategies

Binyan Zhao, Bailing Zhou, Qing Li, Chunyan Su, Jing Ma and Li Yang

MedComm – Future Medicine, 2024, 3
DOI: 10.1002/mef2.70006

Progress of engineered bacteria for tumor therapy

Jin-Xuan Fan, Mei-Ting Niu, You-Teng Qin, Yun-Xia Sun and Xian-Zheng Zhang

Advanced Drug Delivery Reviews, 2022, 185, 114296
DOI: 10.1016/j.addr.2022.114296

Expanding Our Horizons: AIE Materials in Bacterial Research

Michelle M. S. Lee, Eric Y. Yu, Joe H. C. Chau, Jacky W. Y. Lam, Ryan T. K. Kwok and Ben Zhong Tang

Advanced Materials, 2025, 37
DOI: 10.1002/adma.202407707

Engineered bacteria as drug delivery vehicles: Principles and prospects

Yuxi Zhou and Yong Han

Engineering Microbiology, 2022, 2, 100034
DOI: 10.1016/j.engmic.2022.100034

Engineered Bacteria-Based Living Materials for Biotherapeutic Applications

Rabia Omer, Muhammad Zubair Mohsin, Ali Mohsin, Bilal Sajid Mushtaq, Xumeng Huang, Meijin Guo, Yingping Zhuang and Jiaofang Huang

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.870675

Harnessing bacteria for tumor therapy: Current advances and challenges

Lina Guo, Jinsong Ding and Wenhu Zhou

Chinese Chemical Letters, 2024, 35, 108557
DOI: 10.1016/j.cclet.2023.108557

Engineered Bacteria-Nano Hybrid System: The Intelligent Drug Factory for Next-Generation Cancer Immunotherapy

Guisha Zi, Wei Zhou, Ling Zhou, Lingling Wang, Pengdou Zheng and Shuang Wei

Pharmaceutics, 2025, 17, 1349
DOI: 10.3390/pharmaceutics17101349

Universal Fluorescence Light-Up Gram-Staining Technique for Living Bacterial Differentiation

Xingang Liu, Guobin Qi, Min Wu, Yutong Pan and Bin Liu

Chem. Mater., 2021, 33, 9213
DOI: 10.1021/acs.chemmater.1c02817

Multilayered safety framework for living diagnostics in the colon

Sonia Mecacci, Lucía Torregrosa-Barragán, Enrique Asin-Garcia and Robert W. Smith

Front. Syst. Biol., 2023, 3
DOI: 10.3389/fsysb.2023.1240040

Enhancing the antitumor phototherapy efficacy of PCSK9 nanobody-engineered bacteria coated with photosensitizer lipids

Chao Shi, Tingting Wu, Zongfeng Niu, Yingying Wang, Huan Zhao, Yuesheng Gui, Chuan Wang, Kairui Xiao, Weining Yuan, Bo Wang, Yanping Hu, Tingjie Wang, Ran Li, Shixing Wang, Yanan Yu, Yang Wang, Hao Tang, Zhen Li and Yongjun Guo

Materials & Design, 2025, 260, 115121
DOI: 10.1016/j.matdes.2025.115121

Engineered Microorganisms for Advancing Tumor Therapy

Jinxuan Jia, Xiaocheng Wang, Xiang Lin and Yuanjin Zhao

Advanced Materials, 2024, 36
DOI: 10.1002/adma.202313389

Salmonella-based therapeutic strategies: improving tumor microenvironment and bringing new hope for cancer immunotherapy

Xiaoe He, Jiayin Guo, Yanrui Bai, Hui Sun and Jing Yang

Med Oncol, 2024, 42
DOI: 10.1007/s12032-024-02578-0

Advances in Salmonella Typhimurium-based drug delivery system for cancer therapy

Wenfei Chen, Yining Zhu, Zhirong Zhang and Xun Sun

Advanced Drug Delivery Reviews, 2022, 185, 114295
DOI: 10.1016/j.addr.2022.114295

Harnessing Engineered Immune Cells and Bacteria as Drug Carriers for Cancer Immunotherapy

Jingwen Jiang, Yanjuan Huang, Zishan Zeng and Chunshun Zhao

ACS Nano, 2023, 17, 843
DOI: 10.1021/acsnano.2c07607

Bioorthogonal reactions and AIEgen-based metabolically engineered theranostic systems

Kenry and Bin Liu

Chem, 2023, 9, 2078
DOI: 10.1016/j.chempr.2023.04.004

Advances in the combined treatment of solid tumors with nanodelivery systems based on engineered bacteria-TME modulation

Bingjie Guo, Zhaokai Li, Yahui Wang, Baojuan Li, Junyi Zhou, Hang Chen, Meichai Li, Youfa Xu and Xin Wu

Colloids and Surfaces B: Biointerfaces, 2026, 262, 115558
DOI: 10.1016/j.colsurfb.2026.115558

Recent Advances in Spatiotemporal Manipulation of Engineered Bacteria for Precision Cancer Therapy

Xueke Chang, Xiaolin Liu, Xiumei Wang, Lin Ma, Jing Liang and Yan Li

IJN, 2025, Volume 20, 5859
DOI: 10.2147/IJN.S516523

Synthetic engineered bacteria for cancer therapy

Tong Gong and Jinhui Wu

Expert Opinion on Drug Delivery, 2023, 20, 993
DOI: 10.1080/17425247.2023.2241367

Engineering living therapeutics and diagnostics: A new frontier in human health

Raja Selvakumar, Ishita Kumar, Glory J. Onajobi, Yongjoon Yu and Corey J. Wilson

Current Opinion in Systems Biology, 2024, 37, 100484
DOI: 10.1016/j.coisb.2023.100484

Engineering bacteria for enhanced tumor therapy: from surface modification to synthetic genetic circuits

Yuanxiang Wang, Susu Xiao, Wei Yu, Bo Han and Gang Guo

J Hematol Oncol, 2025, 19
DOI: 10.1186/s13045-025-01766-3

Thermo-amplifier circuit in probiotic E. coli for stringently temperature-controlled release of a novel antibiotic

Sourik Dey, Carsten E. Seyfert, Claudia Fink-Straube, Andreas M. Kany, Rolf Müller and Shrikrishnan Sankaran

J Biol Eng, 2024, 18
DOI: 10.1186/s13036-024-00463-y

Top-down bioinspired nanotheranostics with AIE luminogens

Xiaoyu Xu, Luojia Chen, Liupiaopiao Yang, Baoping Li, Yujin Kim, Changyu Yoon, Jiyoung Yoo, Lianrong Wang, Shi Chen, Meijia Gu and Jong Seung Kim

Coordination Chemistry Reviews, 2025, 537, 216681
DOI: 10.1016/j.ccr.2025.216681

Diverse interactions between AIEgens and biomolecules/organisms: Advancing from strategic design to precision theranostics

Qihang Ding, Xiaoyu Xu, Yang Li, Baoping Li, Qimanguli Saiding, Meijia Gu, Wei Tao, Ben Zhong Tang and Jong Seung Kim

Chem, 2024, 10, 2031
DOI: 10.1016/j.chempr.2024.06.018

Bacteria-based immunotherapy for cancer: a systematic review of preclinical studies

Min Zhou, Yucheng Tang, Wenjie Xu, Xinyan Hao, Yongjiang Li, Si Huang, Daxiong Xiang and Junyong Wu

Front. Immunol., 2023, 14
DOI: 10.3389/fimmu.2023.1140463

AIEgen-biomacromolecule conjugates: Visualized delivery and light-controlled theranostic platforms

Siqin Chen, Bowen Li and Bin Liu

Journal of Controlled Release, 2025, 378, 605
DOI: 10.1016/j.jconrel.2024.12.047

Development and Applications of D‐Amino Acid Derivatives‐based Metabolic Labeling of Bacterial Peptidoglycan

Yongfang Zheng, Xinyu Zhu, Mingyi Jiang, Fangfang Cao, Qing You and Xiaoyuan Chen

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202319400

Bacteria-based bioactive materials for cancer imaging and therapy

Ying Chen, Zi-Hao Li, Xuan Zeng and Xian-Zheng Zhang

Advanced Drug Delivery Reviews, 2023, 193, 114696
DOI: 10.1016/j.addr.2023.114696

Advancements in synthetic biology-based bacterial cancer therapy: A modular design approach

Andrés Arboleda-García, Ivan Alarcon-Ruiz, Lissette Boada-Acosta, Yadira Boada, Alejandro Vignoni and Eloisa Jantus-Lewintre

Critical Reviews in Oncology/Hematology, 2023, 190, 104088
DOI: 10.1016/j.critrevonc.2023.104088

The potential use of bacteria and their derivatives as delivery systems for nanoparticles in the treatment of cancer

Shiva Ahmadishoar, Samaa Mones Saeed, Morug Salih Mahdi, Waam Mohammed Taher, Mariem Alwan, Mahmod Jasem Jawad, Atheer Khdyair Hamad and Hossein Gandomkar

Journal of Drug Targeting, 2025, 33, 1272
DOI: 10.1080/1061186X.2025.2489979

Direct Synthesis of Photosensitizable Bacterial Cellulose as Engineered Living Material for Skin Wound Repair

Xingang Liu, Min Wu, Meng Wang, Qida Hu, Jingjing Liu, Yukun Duan and Bin Liu

Advanced Materials, 2022, 34
DOI: 10.1002/adma.202109010

Synergistic Brilliance: Engineered Bacteria and Nanomedicine Unite in Cancer Therapy

Yaofeng Zhou, Qianying Li, Yuhao Wu, Wan Zhang, Lu Ding, Chenlin Ji, Ping Li, Tingtao Chen, Lili Feng, Ben Zhong Tang and Xiaolin Huang

Advanced Materials, 2024, 36
DOI: 10.1002/adma.202313953

Organic functional substance engineered living materials for biomedical applications

Tongtong Wang, Min Wu, Lei Cao and Bin Liu

Biomaterials, 2023, 301, 122248
DOI: 10.1016/j.biomaterials.2023.122248

Development and Applications of D‐Amino Acid Derivatives‐based Metabolic Labeling of Bacterial Peptidoglycan

Yongfang Zheng, Xinyu Zhu, Mingyi Jiang, Fangfang Cao, Qing You and Xiaoyuan Chen

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202319400