Development of a continuous synthesis process for carbamazepine using validated in-line Raman spectroscopy and kinetic modelling for disturbance simulation

Matthew Glace, Wei Wu, Harrison Kraus, David Acevedo, Thomas D. Roper and Adil Mohammad

React. Chem. Eng., 2023, 8, 1032
DOI: 10.1039/D2RE00476C

Keeping an “eye” on the experiment: computer vision for real-time monitoring and control

Rama El-khawaldeh, Mason Guy, Finn Bork, Nina Taherimakhsousi, Kris N. Jones, Joel M. Hawkins, Lu Han, Robert P. Pritchard, Blaine A. Cole, Sebastien Monfette and Jason E. Hein

Chem. Sci., 2024, 15, 1271
DOI: 10.1039/D3SC05491H

Enantioselective synthesis of (−)-tetrabenazine via continuous crystallization-induced diastereomer transformation

Andrew J. Kukor, Noah Depner, Isabelle Cai, John L. Tucker, Jeffrey C. Culhane and Jason E. Hein

Chem. Sci., 2022, 13, 10765
DOI: 10.1039/D2SC01825J

Review of the Application of PAT in the Pharmaceutical Continuous Crystallization Process

Bing Zhao, Hengchang Zang, Liang Zhong, Xiaobo Ma, Haowei Wang, Hui Zhang and Lian Li

CTMC, 2023, 23, 1699
DOI: 10.2174/1568026623666230420112709

Crystal measurement technologies for crystallization processes: Advances, applications, and challenges

Fangkun Zhang, Wenlve Li, Baoming Shan, Yinglong Wang, Zhaoyou Zhu, Yan Huo and Qilei Xu

Measurement, 2024, 231, 114672
DOI: 10.1016/j.measurement.2024.114672

Process Analytical Technology for the Production of Parenteral Lipid Emulsions According to Good Manufacturing Practices

Carsten Grumbach and Peter Czermak

Processes, 2022, 10, 1174
DOI: 10.3390/pr10061174

Real-time particle size analysis using focused beam reflectance measurement as a process analytical technology tool for continuous microencapsulation process

Muhaimin Muhaimin, Anis Yohana Chaerunisaa and Roland Bodmeier

Sci Rep, 2021, 11
DOI: 10.1038/s41598-021-98984-9

Continuous Antisolvent Crystallization of L-Histidine: Impact of Process Parameters and Kinetic Estimation

Peng Liu, Li Yang, Yixin Ma, Yan Zhang, Haoliang Wang, Jingcai Cheng and Chao Yang

Ind. Eng. Chem. Res., 2024, 63, 2831
DOI: 10.1021/acs.iecr.3c03870

In-situ measurement of particle length distribution by FBRM with application to needle- or rod-shape crystallization processes

Yan Cui, Tao Liu, Feiran Sun, Bo Song and Rolf Findeisen

Chemical Engineering Research and Design, 2024, 207, 12
DOI: 10.1016/j.cherd.2024.05.023

Nondestructive techniques for pharmaceutical drug product characterization

Sarwar Beg, Kailash Ahirwar, Waleed H. Almalki, Salem S. Almujri, Abdulrahman Alhamyani, Mahfoozur Rahman and Rahul Shukla

Drug Discovery Today, 2025, 30, 104249
DOI: 10.1016/j.drudis.2024.104249

Monitoring Aggregation Processes in Multiphase Systems: A Review

Maria Graça Rasteiro and Antti Koponen

Powders, 2024, 3, 77
DOI: 10.3390/powders3010007

Theoretical Analysis of the Factors Determining the Crystal Size Distribution (CSD) During Crystallization in Solution: Rates of Crystal Growth

Christo N. Nanev

Crystals, 2025, 15, 653
DOI: 10.3390/cryst15070653

Sensor Fusion and Calibration-Based Adaptive Image Analysis Procedure for In Situ Crystal Size Measurement

Wei-Lee Wu, Madeline M. Mills, Ulrich Schacht, Charlie Rabinowitz, Vaso Vlachos and Zoltan K. Nagy

Crystal Growth & Design, 2023, 23, 7076
DOI: 10.1021/acs.cgd.3c00273

Unravelling the polymorphic characteristics of carbamazepine through additive-assisted sonocrystallisation

Sandesh Shrinivas Kalantri and Manishkumar D. Yadav

Indian Chemical Engineer, 2024, 66, 670
DOI: 10.1080/00194506.2024.2381119

Automatic Control of Nucleation and Crystal Growth Using Online Raman Analyzer

Aofei Li, Boxue Chang, Zhen Li, Biao Chen, Kaidi Ji, Yangshun Chen, Shiqiang Ou, Fengming Zhang, Jiaoning Wei and Yinlan Ruan

Processes, 2024, 12, 774
DOI: 10.3390/pr12040774

Process analytical technology in Downstream-Processing of Drug Substances– A review

Peter Neugebauer, Manuel Zettl, Daniel Moser, Johannes Poms, Lisa Kuchler and Stephan Sacher

International Journal of Pharmaceutics, 2024, 661, 124412
DOI: 10.1016/j.ijpharm.2024.124412

Evaluating the Foaming Behavior of High-Viscosity Non-Newtonian Fluids

Jiahao Zhang, Zhendong Zhu, Feihong Wang, Wenhui Feng, Hongyuan Wei and Leping Dang

Ind. Eng. Chem. Res., 2024, 63, 11776
DOI: 10.1021/acs.iecr.4c00568

An audit of pharmaceutical continuous manufacturing regulatory submissions and outcomes in the US

Adam C. Fisher, William Liu, Andreas Schick, Mahesh Ramanadham, Sharmista Chatterjee, Raphael Brykman, Sau L. Lee, Steven Kozlowski, Ashley B. Boam, Stelios C. Tsinontides and Michael Kopcha

International Journal of Pharmaceutics, 2022, 622, 121778
DOI: 10.1016/j.ijpharm.2022.121778

Retrieving mean volumetric properties of multiphase flows from 2D images: A new approach combining deep learning algorithms and 3D modelling

Kassem Dia, Fabrice Lamadie and Johan Debayle

Chemical Engineering Science, 2023, 279, 118933
DOI: 10.1016/j.ces.2023.118933

Experimental Nonlinear Model Predictive Control of Crystal Size and Yield in Batch Cooling Crystallization Enabled by Soft Sensor and Symbolic-Based Calibration Model

Fernando Arrais Romero Dias Lima, Marcellus Guedes Fernandes de Moraes, Argimiro Resende Secchi, Maurício B. de Souza and Martha A. Grover

Ind. Eng. Chem. Res., 2025, 64, 23582
DOI: 10.1021/acs.iecr.5c03894

Modeling and Predictive Control of Cooling Crystallization of Potassium Sulfate by Dynamic Image Analysis: Exploring Phenomenological and Machine Learning Approaches

Marcellus Guedes Fernandes de Moraes, Fernando Arrais Romero Dias Lima, Paulo Laranjeira da Cunha Lage, Maurício B. de Souza, Amaro Gomes Barreto and Argimiro Resende Secchi

Ind. Eng. Chem. Res., 2023, 62, 9515
DOI: 10.1021/acs.iecr.3c00739

Models for converting CLD to PSD for bimodal distributions of particles

Vaishnavi G. Honavar, Ajinkya V. Pandit, Mehakpreet Singh and Vivek V. Ranade

Chemical Engineering Research and Design, 2023, 200, 576
DOI: 10.1016/j.cherd.2023.11.021

Design and optimization of antisolvent crystallization of L-aspartic acid using response surface model: Focused beam reflectance measurements

Sudhakar P, Alka Kumari, Sazal Kundu, Vivek Ravi Sankar, Prathap Kumar Thella, Kalpit Shah and Suresh K. Bhargava

Chemical Engineering Research and Design, 2023, 191, 172
DOI: 10.1016/j.cherd.2023.01.020

Recent Advances in the Monitoring of Protein Crystallization Processes in Downstream Processing

Brigitte Walla, Daniel Bischoff, Iliana Corona Viramontes, Sergio Montes Figueredo and Dirk Weuster-Botz

Crystals, 2023, 13, 773
DOI: 10.3390/cryst13050773

Rapid, Automated Measurement of Dynamic Size Distributions and Size-Dependent Growth Rates of Crystal Ensembles within Microfluidic Flow Cells

Ariel Yi Hui Chua, Gian Yion Tan, Eunice Wan Qi Yeap, David Millar Walker, Joel M. Hawkins and Saif A. Khan

Crystal Growth & Design, 2022, 22, 2869
DOI: 10.1021/acs.cgd.1c01215

Residence Time Distribution Characterization and Proof-of-Concept of a Novel Stacked 7-Stage Continuous Crystallizer Cascade with Diaphragm-Driven Slurry Transfer

Giovanni Aprile, Ajinkya V. Pandit, Jody Albertazzi, Thomas Vetter, Robert Viano, Lorenzo Milani, Andrea Adamo, Allan S. Myerson and Torsten Stelzer

Ind. Eng. Chem. Res., 2024, 63, 18199
DOI: 10.1021/acs.iecr.4c02153

Effectiveness of kinetic hydrate promoters in improving gas hydrate-based flare gas uptake rate reduced by mechanical optimization in stirred cell reactor system

Joshua Worley, Sriram Ravichandran, Ramesh A. Kini, Nirav Shah and Carolyn Koh

Journal of Environmental Chemical Engineering, 2025, 13, 119703
DOI: 10.1016/j.jece.2025.119703

Targeting Particle Size Specification in Pharmaceutical Crystallization: A Review on Recent Process Design and Development Strategies and Particle Size Measurements

Fan Liu, Sujay D. Bagi, Qinglin Su, Rajshree Chakrabarti, Rita Barral, Janaka C. Gamekkanda, Chuntian Hu and Salvatore Mascia

Org. Process Res. Dev., 2022, 26, 3190
DOI: 10.1021/acs.oprd.2c00277

Impurity Profiling for a Scalable Continuous Synthesis and Crystallization of Carbamazepine Drug Substance

Matthew Glace, Harrison Kraus, Wei Wu, David Acevedo, Dongxia Liu, Thomas D. Roper and Adil Mohammad

Org. Process Res. Dev., 2024, 28, 2013
DOI: 10.1021/acs.oprd.4c00081