Emerging nanomaterials applied for tackling the COVID-19 cytokine storm

Xi Yang, Jia You, Yuanfeng Wei, Huawei Li, Ling Gao, Qing Guo, Ying Huang, Changyang Gong and Cheng Yi

J. Mater. Chem. B, 2021, 9, 8185
DOI: 10.1039/D1TB01446C

Sulfation of thiol–maleimide crosslinked hydrogels modulates material properties and cell biocompatibility

Lasse Riediger, Lei Wang, Peer Nölte, Cosmin Butnarasu, Peng Tang, Yannic Kerkhoff, Elisa Quaas, Justin Arenhoevel, Daniel Lauster, Yi-An Yang, Nan Ma and Rainer Haag

Mater. Adv., 2026, 7, 2738
DOI: 10.1039/D5MA01183C

Quantitative prediction of charge regulation in oligopeptides

Raju Lunkad, Anastasiia Murmiliuk, Pascal Hebbeker, Milan Boublík, Zdeněk Tošner, Miroslav Štěpánek and Peter Košovan

Mol. Syst. Des. Eng., 2021, 6, 122
DOI: 10.1039/D0ME00147C

Electrically Controlled Click‐Chemistry for Assembly of Bioactive Hydrogels on Diverse Micro‐ and Flexible Electrodes

Aruã Clayton Da Silva, Teuku Fawzul Akbar, Thomas Edward Paterson, Carsten Werner, Christoph Tondera and Ivan Rusev Minev

Macromol. Rapid Commun., 2022, 43
DOI: 10.1002/marc.202200557

The Influence of Sulfation Degree of Glycosaminoglycan-Functionalized 3D Collagen I Networks on Cytokine Profiles of In Vitro Macrophage–Fibroblast Cocultures

Franziska Ullm, Alexander Renner, Uwe Freudenberg, Carsten Werner and Tilo Pompe

Gels, 2024, 10, 450
DOI: 10.3390/gels10070450

Interaction of Heparin with Proteins: Hydration Effects

Weronika Malicka, Rainer Haag and Matthias Ballauff

J. Phys. Chem. B, 2022, 126, 6250
DOI: 10.1021/acs.jpcb.2c04928

Analysis of the Binding of Cytokines to Highly Charged Polymer Networks

Uwe Freudenberg, Passant Atallah, Jens‐Uwe Sommer, Carsten Werner and Matthias Ballauff

Macromolecular Bioscience, 2023, 23
DOI: 10.1002/mabi.202200561

Dynamic Hydrogels with Tunable Mechanics for 3D Organoid Derivation

Xueyong Xie, Xuewen Chen, Jian Zhou, Tiansong Wang, Gen Yang, Fei Han and Zhao Wei

Small, 2025, 21
DOI: 10.1002/smll.202501862

Tuning Barrier Properties of Biological Hydrogels

Jennifer L. Schiller and Samuel K. Lai

ACS Appl. Bio Mater., 2020, 3, 2875
DOI: 10.1021/acsabm.0c00187

Wechselwirkung von Polyelektrolyt‐Architekturen mit Proteinen und Biosystemen

Katharina Achazi, Rainer Haag, Matthias Ballauff, Jens Dernedde, Jayachandran N. Kizhakkedathu, Dusica Maysinger and Gerd Multhaup

Angewandte Chemie, 2021, 133, 3926
DOI: 10.1002/ange.202006457

Conductive Hydrogels for Exogenous Sensing and Cell Fate Control

Teuku Fawzul Akbar, Carlos Alejandro Jimenez‐Rodriguez, Railia Biktimirova, Ilka Hermes, Thomas Kurth, My Duyen Pham, Mikhail Tsurkan, Jens Friedrichs, Francis L. C. Morgan, Hans Kleemann, Olga Guskova, Uwe Freudenberg, Peter Fratzl, Carsten Werner, Christoph Tondera and Ivan R. Minev

Advanced Materials, 2026
DOI: 10.1002/adma.72866

Glycosaminoglycan-based biomaterials for growth factor and cytokine delivery: Making the right choices

Daniel Hachim, Thomas E. Whittaker, Hyemin Kim and Molly M. Stevens

Journal of Controlled Release, 2019, 313, 131
DOI: 10.1016/j.jconrel.2019.10.018

Inflammation‐Controlled Anti‐Inflammatory Hydrogels

Tina Helmecke, Dominik Hahn, Nadine Matzke, Lisa Ferdinand, Lars Franke, Sebastian Kühn, Gunter Fischer, Carsten Werner and Manfred F. Maitz

Advanced Science, 2023, 10
DOI: 10.1002/advs.202206412

Thermodynamic Analysis of the Interaction of Heparin with Lysozyme

Jacek Janusz Walkowiak, Matthias Ballauff, Ralf Zimmermann, Uwe Freudenberg and Carsten Werner

Biomacromolecules, 2020, 21, 4615
DOI: 10.1021/acs.biomac.0c00780

Breaking Bruch's: How changes in Bruch's membrane influence retinal homeostasis

Simon J. Clark, Christine Curcio, Andrew D. Dick, Sarah Doyle, Malia Edwards, Miguel Flores-Bellver, Daniel Hass, Rachel Lennon, Christopher B Toomey and Bärbel Rohrer

Experimental Eye Research, 2025, 255, 110343
DOI: 10.1016/j.exer.2025.110343

Microgels With Electrostatically Controlled Molecular Affinity to Direct Morphogenesis

Sebastian Kühn, Valentina Magno, Ralf Zimmermann, Yanuar Dwi Putra Limasale, Passant Atallah, Aukha Stoppa, Max J. Männel, Julian Thiele, Jens Friedrichs, Uwe Freudenberg and Carsten Werner

Advanced Materials, 2025, 37
DOI: 10.1002/adma.202409731

Tuning the Local Availability of VEGF within Glycosaminoglycan‐Based Hydrogels to Modulate Vascular Endothelial Cell Morphogenesis

Yanuar Dwi Putra Limasale, Passant Atallah, Carsten Werner, Uwe Freudenberg and Ralf Zimmermann

Adv Funct Materials, 2020, 30
DOI: 10.1002/adfm.202000068

Sulfation Pattern Dependent Iron(III) Mediated Interleukin‐8 Glycan Binding

Francesco Brunori, Deepak Kumar Padhi, Israel Alshanski, Joanna Freyse, Jan‐Niklas Dürig, Anja Penk, Luigi Vaccaro, Mattan Hurevich, Jörg Rademann and Shlomo Yitzchaik

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202100552

Ion Pairing and Dielectric Decrement in Glycosaminoglycan Brushes

James D. Sterling, Wenjuan Jiang, Wesley M. Botello-Smith and Yun L. Luo

J. Phys. Chem. B, 2021, 125, 2771
DOI: 10.1021/acs.jpcb.0c11571

Sustained Release of Human Adipose Tissue Stem Cell Secretome from Star‐Shaped Poly(ethylene glycol) Glycosaminoglycan Hydrogels Promotes Motor Improvements after Complete Transection in Spinal Cord Injury Rat Model

Deolinda Silva, Lucas Schirmer, Tiffany S. Pinho, Passant Atallah, Jorge R. Cibrão, Rui Lima, João Afonso, Sandra B‐Antunes, Cláudia R. Marques, João Dourado, Uwe Freudenberg, Rui A. Sousa, Carsten Werner and António J. Salgado

Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202202803

Role of pKA in Charge Regulation and Conformation of Various Peptide Sequences

Raju Lunkad, Anastasiia Murmiliuk, Zdeněk Tošner, Miroslav Štěpánek and Peter Košovan

Polymers, 2021, 13, 214
DOI: 10.3390/polym13020214

Polymer Hydrogels to Guide Organotypic and Organoid Cultures

Valentina Magno, Andrea Meinhardt and Carsten Werner

Adv Funct Materials, 2020, 30
DOI: 10.1002/adfm.202000097

Poly(2‐alkyl‐2‐oxazoline)‐Heparin Hydrogels—Expanding the Physicochemical Parameter Space of Biohybrid Materials

Dominik Hahn, Jannick M. Sonntag, Steffen Lück, Manfred F. Maitz, Uwe Freudenberg, Rainer Jordan and Carsten Werner

Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202101327

Mechanics of 3D Cell–Hydrogel Interactions: Experiments, Models, and Mechanisms

Franck J. Vernerey, Shankar Lalitha Sridhar, Archish Muralidharan and Stephanie J. Bryant

Chem. Rev., 2021, 121, 11085
DOI: 10.1021/acs.chemrev.1c00046

Understanding the Interaction of Polyelectrolyte Architectures with Proteins and Biosystems

Katharina Achazi, Rainer Haag, Matthias Ballauff, Jens Dernedde, Jayachandran N. Kizhakkedathu, Dusica Maysinger and Gerd Multhaup

Angew Chem Int Ed, 2021, 60, 3882
DOI: 10.1002/anie.202006457

Electronic tissue technologies for seamless biointerfaces

Ivan R. Minev

Journal of Polymer Science, 2023, 61, 1707
DOI: 10.1002/pol.20230111

Hemocompatible Coatings of Catheters Equipped with Electrochemical Sensors for Real-Time Monitoring of Critical Parameters in the Blood

Stephanie Klinghammer, Taufhik Hossain Tonmoy, Željko Janićijević, Manfred F. Maitz, Sascha Balakin, Marta Vicini, Leif Riemenschneider, Luis-Antonio Panes-Ruiz, Rebecca Bockholt, Lars Heubner, Peter Markus Spieth, Carsten Werner, Bergoi Ibarlucea, Larysa Baraban and Gianaurelio Cuniberti

ACS Appl. Polym. Mater., 2025, 7, 9349
DOI: 10.1021/acsapm.5c01708

Chemokine‐Capturing Wound Contact Layer Rescues Dermal Healing

Lucas Schirmer, Passant Atallah, Uwe Freudenberg and Carsten Werner

Advanced Science, 2021, 8
DOI: 10.1002/advs.202100293

Capturing Cytokines with Advanced Materials: A Potential Strategy to Tackle COVID‐19 Cytokine Storm

Qian‐Fang Meng, Rui Tian, Haiyi Long, Xianjia Wu, Jialin Lai, Olga Zharkova, Jiong‐Wei Wang, Xiaoyuan Chen and Lang Rao

Advanced Materials, 2021, 33
DOI: 10.1002/adma.202100012

Natural Presentation of Glycosaminoglycans in Synthetic Matrices for 3D Angiogenesis Models

Cornelia Zapp, Patricia Mundinger and Heike Boehm

Front. Cell Dev. Biol., 2021, 9
DOI: 10.3389/fcell.2021.729670

Mineralized Cryogel/Hydrogel Constructs to Recapitulate Early Breast Cancer Bone Metastasis In Vitro

Jana Sievers‐Liebschner, Petra B. Welzel, Maximilian Fusenig, Linda Sturm, Dagmar Pette, Wolfgang Wagermaier, Claudia Fischbach, Peter Fratzl and Carsten Werner

Advanced Science, 2026, 13
DOI: 10.1002/advs.202519798

Glycosaminoglycan Concentration and Sulfation Patterns of Biohybrid Polymer Matrices Direct Microvascular Network Formation and Stability

Yanuar Dwi Putra Limasale, Maximilian Fusenig, Marten Samulowitz, Passant Atallah, Jana Sievers, Nicholas Dennison, Uwe Freudenberg, Jens Friedrichs and Carsten Werner

Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202411475

A synthetic hydrogel niche reveals the interplay of matrix adhesion and mechanics in human epiblast model development

Yanuar Dwi Putra Limasale, Passant Atallah, Andrea Meinhardt, Ayham Frra, Aukha Stoppa, Manfred F. Maitz, Jens Friedrichs, Uwe Freudenberg and Carsten Werner

Materials Today, 2026, 92, 269
DOI: 10.1016/j.mattod.2025.12.007

Tuning the network charge of biohybrid hydrogel matrices to modulate the release of SDF-1

Sebastian Kühn, Joanna Freyse, Passant Atallah, Jörg Rademann, Uwe Freudenberg and Carsten Werner

Biological Chemistry, 2021, 402, 1453
DOI: 10.1515/hsz-2021-0175

Unravelling the molecular network structure of biohybrid hydrogels

Jana Sievers-Liebschner, Ron Dockhorn, Jens Friedrichs, Thomas Kurth, Peter Fratzl, Jens-Uwe Sommer, Carsten Werner and Uwe Freudenberg

Materials Today Bio, 2025, 34, 102249
DOI: 10.1016/j.mtbio.2025.102249

Precision Culture Scaling to Establish High‐Throughput Vasculogenesis Models

Nicholas R. Dennison, Maximilian Fusenig, Lisa Grönnert, Manfred F. Maitz, Maria Alejandra Ramirez Martinez, Manja Wobus, Uwe Freudenberg, Martin Bornhäuser, Jens Friedrichs, Peter D. Westenskow and Carsten Werner

Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202400388