Xin-Chen Jiang, Fang-Hai Tu, Li-Yuan Wei, Bo-Zheng Wang, Hao Yuan, Jing-Mei Yuan, Yong Rao, Shi-Liang Huang, Qing-Jiang Li, Tian-Miao Ou, Hong-Gen Wang, Jia-Heng Tan, Shuo-Bin Chen and Zhi-Shu Huang

J. Med. Chem., 2022, 65, 12346
DOI: 10.1021/acs.jmedchem.2c01058

Insights into the Molecular Structure, Stability, and Biological Significance of Non-Canonical DNA Forms, with a Focus on G-Quadruplexes and i-Motifs

Patrycja Obara, Paweł Wolski and Tomasz Pańczyk

Molecules, 2024, 29, 4683
DOI: 10.3390/molecules29194683

Selectively Identifying Exposed-over-Unexposed C–C+ Pairs in Human Telomeric i-Motif Structures with Length-Dependent Polymorphism

Tong Yang, Qiuda Xu, Jiahui Chen, Pei-Ke Jia, Bin-Bin Xie, Dandan Wang, Xiaoshun Zhou and Yong Shao

Anal. Chem., 2022, 94, 14994
DOI: 10.1021/acs.analchem.2c02875

Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response

Tong Che, Shuo-Bin Chen, Jia-Li Tu, Bo Wang, Yu-Qing Wang, Yan Zhang, Jing Wang, Zeng-Qing Wang, Ze-Peng Zhang, Tian-Miao Ou, Yong Zhao, Jia-Heng Tan and Zhi-Shu Huang

J. Med. Chem., 2018, 61, 3436
DOI: 10.1021/acs.jmedchem.7b01615

Identification and Classification of Functional Split G-Quadruplexes Using Machine Learning-Guided Activity Screening

Pranotosh Das, Avimanyu Das and Manish Debnath

ACS Appl. Bio Mater., 2025, 8, 4844
DOI: 10.1021/acsabm.5c00215

Modulating gene expression in breast cancer via DNA secondary structure and the CRISPR toolbox

Jessica A Kretzmann, Kelly L Irving, Nicole M Smith and Cameron W Evans

NAR Cancer, 2021, 3
DOI: 10.1093/narcan/zcab048

i-Motif-Binding Ligands and Their Effects on the Structure and Biological Functions of i-Motif

Shadi Sedghi Masoud and Kazuo Nagasawa

Chem. Pharm. Bull., 2018, 66, 1091
DOI: 10.1248/cpb.c18-00720

Modulation of Nrf2 expression by targeting i-motif DNA

E. F. Warner, D. Guneri, M. A. O’Connell, C. J. MacDonald and Z. A. E. Waller

Commun Chem, 2025, 8
DOI: 10.1038/s42004-024-01387-w

Furan-modified PNA probes for covalent targeting and ligation of nucleic acids

Lessandro De Paepe, Enrico Cadoni, Alex Manicardi and Annemieke Madder

Methods, 2023, 218, 210
DOI: 10.1016/j.ymeth.2023.08.010

i-Motif DNA: structural features and significance to cell biology

Hala Abou Assi, Miguel Garavís, Carlos González and Masad J Damha

Nucleic Acids Research, 2018, 46, 8038
DOI: 10.1093/nar/gky735

Peptides and Peptide Derivatives as G‐Quadruplex Targeting Ligands: A Brief Review

Shubhanwita Basak, Soumi Biswas and Jishu Naskar

ChemistrySelect, 2023, 8
DOI: 10.1002/slct.202302177

Ligand Design to Acquire Specificity to Intended G‐Quadruplex Structures

Sefan Asamitsu, Toshikazu Bando and Hiroshi Sugiyama

Chemistry A European J, 2019, 25, 417
DOI: 10.1002/chem.201802691

Design, Synthesis, and Evaluation of Novel p-(Methylthio)styryl Substituted Quindoline Derivatives as Neuroblastoma RAS (NRAS) Repressors via Specific Stabilizing the RNA G-Quadruplex

Wang Peng, Zhi-Yin Sun, Qi Zhang, Sui-Qi Cheng, Shi-Ke Wang, Xiao-Na Wang, Guo-Tao Kuang, Xiao-Xuan Su, Jia-Heng Tan, Zhi-Shu Huang and Tian-Miao Ou

J. Med. Chem., 2018, 61, 6629
DOI: 10.1021/acs.jmedchem.8b00257

Reversible Photocontrol of DNA Melting by Visible‐Light‐Responsive F4‐Coordinated Azobenzene Compounds

Marta Dudek, Marco Deiana, Ziemowit Pokladek, Krzysztof Pawlik and Katarzyna Matczyszyn

Chemistry A European J, 2018, 24, 18963
DOI: 10.1002/chem.201803529

G-Quadruplex and I-Motif Structures within the Telomeric DNA Duplex. A Molecular Dynamics Analysis of Protonation States as Factors Affecting Their Stability

Pawel Wolski, Krzysztof Nieszporek and Tomasz Panczyk

J. Phys. Chem. B, 2019, 123, 468
DOI: 10.1021/acs.jpcb.8b11547

Targeting c-MYC G-Quadruplexes for Cancer Treatment with Small Molecules

Prasanth Thumpati, Sachchida Nand Rai, Chandrabhan Prajapati, Kakarla Ramakrishna and Santosh Kumar Singh

Sci. Pharm., 2025, 93, 6
DOI: 10.3390/scipharm93010006

Synthesis and Biological Evaluation of Oleanolic Acid Derivatives as Selective Vascular Endothelial Growth Factor Promoter i-Motif Ligands

Huang Zeng, Shuangshuang Kang, Yu Zhang, Ke Liu, Qian Yu, Ding Li and Lin-Kun An

IJMS, 2021, 22, 1711
DOI: 10.3390/ijms22041711

5-Fluoro-2′-deoxyuridine as an efficient 19F NMR reporter for G-quadruplex and i-motif structures

Bhakti P. Rout, Sarupa Roy and Seergazhi G. Srivatsan

Bioorganic & Medicinal Chemistry Letters, 2025, 117, 130060
DOI: 10.1016/j.bmcl.2024.130060

An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer

Victoria Sanchez-Martin, Carmen Lopez-Pujante, Miguel Soriano-Rodriguez and Jose A. Garcia-Salcedo

IJMS, 2020, 21, 8900
DOI: 10.3390/ijms21238900

Targeting aloe active compounds to c-KIT promoter G-quadruplex and comparative study of their anti proliferative property

Abhi Das, Jeet Chakraborty, Soching Luikham, Sayanika Banerjee, Jhimli Bhattacharya and Sanjay Dutta

Journal of Biomolecular Structure and Dynamics, 2023, 41, 9686
DOI: 10.1080/07391102.2022.2145370

Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex

Debasish Dutta, Manish Debnath, Diana Müller, Rakesh Paul, Tania Das, Irene Bessi, Harald Schwalbe and Jyotirmayee Dash

Nucleic Acids Research, 2018, 46, 5355
DOI: 10.1093/nar/gky385

Syntheses and evaluation of new Quinoline derivatives for inhibition of hnRNP K in regulating oncogene c-myc transcription

Bing Shu, Ping Zeng, Shuangshuang Kang, Peng-Hui Li, Dexuan Hu, Guotao Kuang, Jiaojiao Cao, Xiaoya Li, Meiling Zhang, Lin-Kun An, Zhi-Shu Huang and Ding Li

Bioorganic Chemistry, 2019, 85, 1
DOI: 10.1016/j.bioorg.2018.12.020

Affinity-selected peptide ligands specifically bind i-motif DNA and modulate c-Myc gene expression

Dilek Guneri, Summer Rosonovski, Effrosyni Alexandrou, Shuang Chen, Jessica King, Christopher A Waudby, Shozeb Haider, Christoper J Morris and Zoë A E Waller

Nucleic Acids Research, 2025, 53
DOI: 10.1093/nar/gkaf1052

Syntheses and evaluation of acridone derivatives as anticancer agents targeting Kras promoter i-motif structure

Zuzhuang Wei, Xiaomin Lin, Siyi Wang, Jiahui Zhang, Dongsheng Ji, Xue Gong, Zhi-Shu Huang, Bing Shu and Ding Li

Bioorganic Chemistry, 2023, 136, 106526
DOI: 10.1016/j.bioorg.2023.106526

Aptamer-Functionalized Binary-Drug Delivery System for Synergetic Obesity Therapy

Xu Chen, Xiaoyun He, Ruxin Gao, Xinyue Lan, Longjiao Zhu, Keren Chen, Yanzhou Hu, Kunlun Huang and Wentao Xu

ACS Nano, 2022, 16, 1036
DOI: 10.1021/acsnano.1c08690

Interactions between a Bioflavonoid and c-MYC Promoter G-Quadruplex DNA: Ensemble and Single-Molecule Investigations

Sneha Paul, Sk Saddam Hossain, Bala Divya M and Anunay Samanta

J. Phys. Chem. B, 2019, 123, 2022
DOI: 10.1021/acs.jpcb.9b00335

G‐Quadruplex‐Binding Small Molecule Induces Synthetic Lethality in Breast Cancer Cells by Inhibiting c‐MYC and BCL2 Expression

Rakesh Paul, Tania Das, Manish Debnath, Ajay Chauhan and Jyotirmayee Dash

ChemBioChem, 2020, 21, 963
DOI: 10.1002/cbic.201900534

Regulation of gene expression by targeting DNA secondary structures

Ritapa Chaudhuri, Khushnood Fatma and Jyotirmayee Dash

J Chem Sci, 2021, 133
DOI: 10.1007/s12039-021-01898-2

Environment-Sensitive Nucleoside Probe Unravels the Complex Structural Dynamics of i-Motif DNAs

Saddam Y. Khatik and Seergazhi G. Srivatsan

Bioconjugate Chem., 2022, 33, 1515
DOI: 10.1021/acs.bioconjchem.2c00237

Of Molecules, Time, and Space Resolution: An Autobiography of Kankan Bhattacharyya

Kankan Bhattacharyya

J. Phys. Chem. B, 2022, 126, 3464
DOI: 10.1021/acs.jpcb.2c02492

Synthesis and biological properties of small molecules — ligands of non-canonical DNA and RNA structures

M. S. Abramovich, P. V. Zaikina, E. S. Barskaya and E. K. Beloglazkina

RUSS CHEM REV, 2024, 93, RCR5134
DOI: 10.59761/RCR5134

Interaction of Human Telomeric i-Motif DNA with Single-Walled Carbon Nanotubes: Insights from Molecular Dynamics Simulations

Pawel Wolski, Patrycja Wojton, Krzysztof Nieszporek and Tomasz Panczyk

J. Phys. Chem. B, 2019, 123, 10343
DOI: 10.1021/acs.jpcb.9b07292

G-Quadruplexes in c-MYC Promoter as Targets for Cancer Therapy

Bárbara Bahls, Israa M. Aljnadi, Rita Emídio, Eduarda Mendes and Alexandra Paulo

Biomedicines, 2023, 11, 969
DOI: 10.3390/biomedicines11030969

Molecular dynamics analysis of stabilities of the telomeric Watson-Crick duplex and the associated i-motif as a function of pH and temperature

Tomasz Panczyk and Pawel Wolski

Biophysical Chemistry, 2018, 237, 22
DOI: 10.1016/j.bpc.2018.03.006

Side-Chain-Dependent Binding of bis-Naphthalimide Self-Assembled Nanoparticles to G-Quadruplex DNA for Potential Anticancer Therapy

Goutam Kulsi, Annie Agnes Suganya Samson, Baskaran Purushothaman and Joon Myong Song

ACS Appl. Nano Mater., 2020, 3, 1339
DOI: 10.1021/acsanm.9b02187

Targeting a KRAS i‐motif forming sequence by unmodified and gamma‐modified peptide nucleic acid oligomers

Srijani Sarkar, Gabriela Colón‐Roura, Alexander Pearse and Bruce A. Armitage

Biopolymers, 2023, 114
DOI: 10.1002/bip.23529

Single-Molecule Analysis of Nanocircle-Embedded I-Motifs under Crowding

Anoja Megalathan, Kalani M. Wijesinghe, Leslie Ranson and Soma Dhakal

J. Phys. Chem. B, 2021, 125, 2193
DOI: 10.1021/acs.jpcb.0c09640

Chemical Regulation of DNA i‐Motifs for Nanobiotechnology and Therapeutics

Manish Debnath, Khushnood Fatma and Jyotirmayee Dash

Angewandte Chemie, 2019, 131, 2968
DOI: 10.1002/ange.201813288

Insights into the Folding Pathway of a c-MYC-Promoter-Based i-Motif DNA in Crowded Environments at the Single-Molecule Level

Sneha Paul, Sk Saddam Hossain and Anunay Samanta

J. Phys. Chem. B, 2020, 124, 763
DOI: 10.1021/acs.jpcb.9b10633

Development of a Smart Fluorescent Probe Specifically Interacting with C-Myc I-Motif

Zuzhuang Wei, Bobo Liu, Xiaomin Lin, Jing Wang, Zhi-Shu Huang and Ding Li

IJMS, 2022, 23, 3872
DOI: 10.3390/ijms23073872

Visible light-driven i-motif-based DNAzymes

Tong Yang, Shuzhen Peng, Ruidi Zeng, Qiuda Xu, Xiong Zheng, Dandan Wang, Xiaoshun Zhou and Yong Shao

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 270, 120845
DOI: 10.1016/j.saa.2021.120845

Detection of radon with biosensors based on the lead(II)-induced conformational change of aptamer HTG and malachite green fluorescence probe

Shiya Li, Hongwen Liu, Guiying Yang, Shimeng Liu, Ran Liu and Changyin Lv

Journal of Environmental Radioactivity, 2018, 195, 60
DOI: 10.1016/j.jenvrad.2018.09.021

Hypothesis: Regulation of neuroplasticity may involve I-motif and G-quadruplex DNA formation modulated by epigenetic mechanisms

German Todorov and Catarina Cunha

Medical Hypotheses, 2019, 127, 129
DOI: 10.1016/j.mehy.2019.04.003

A red light-triggered chemical tool for sequence-specific alkylation of G-quadruplex and I-motif DNA

Enrico Cadoni, Lessandro De Paepe, Gertjan Colpaert, Ruben Tack, Dries Waegeman, Alex Manicardi and Annemieke Madder

Nucleic Acids Research, 2023, 51, 4112
DOI: 10.1093/nar/gkad189

The interactions of 9-methoxyluminarine with Bcl-2 G-quadruplex

J. Nowak-Karnowska, A. Głuszyńska, J. Kosman, S. Haider and A. Dembska

Journal of Molecular Structure, 2025, 1348, 143531
DOI: 10.1016/j.molstruc.2025.143531

Live Cell Microscopy: A Physical Chemistry Approach

Somen Nandi, Surajit Ghosh and Kankan Bhattacharyya

J. Phys. Chem. B, 2018, 122, 3023
DOI: 10.1021/acs.jpcb.7b11689

Emerging roles of i-motif in gene expression and disease treatment

Xiaoqing Luo, Jianye Zhang, Yue Gao, Weifei Pan, Yayuan Yang, Xu Li, Lingfei Chen, Chang Wang and Yuqing Wang

Front. Pharmacol., 2023, 14
DOI: 10.3389/fphar.2023.1136251

Analysis of Interactions between Telomeric i‐Motif DNA and a Cyclic Tetraoxazole Compound

Shadi Sedghi Masoud, Yudai Yamaoki, Yue Ma, Adrien Marchand, Fernaldo Richtia Winnerdy, Valérie Gabelica, Anh Tuân Phan, Masato Katahira and Kazuo Nagasawa

ChemBioChem, 2018, 19, 2268
DOI: 10.1002/cbic.201800425

G4 Sensing Pyridyl‐Thiazole Polyamide Represses c‐KIT Expression in Leukemia Cells

Raj Paul, Debasish Dutta, Tania Das, Manish Debnath and Jyotirmayee Dash

Chemistry A European J, 2021, 27, 8590
DOI: 10.1002/chem.202100907

Quadruplex Ligands in Cancer Therapy

Victoria Sanchez-Martin, Miguel Soriano and Jose Antonio Garcia-Salcedo

Cancers, 2021, 13, 3156
DOI: 10.3390/cancers13133156

Microscopic Insight into pH-Dependent Conformational Dynamics and Noncanonical Base Pairing in Telomeric i-Motif DNA

Manas Mondal and Yi Qin Gao

J. Phys. Chem. Lett., 2022, 13, 5109
DOI: 10.1021/acs.jpclett.2c00640

Synthesis, and molecular docking studies of novel 1,2,3-triazoles-linked pyrazole carboxamides as significant anti-microbial and anti-cancer agents

Leila Kamrani Tamardash, Mohammad Bakherad, Hamid Bakherad, Fatemeh Jalali, Zeinab Mozafari and Ali Keivanloo

Results in Chemistry, 2024, 11, 101842
DOI: 10.1016/j.rechem.2024.101842

Discovery of “folded DNA” structures in human cells: Potential drug targets

Robert B. Raffa, Joseph V. Pergolizzi, Robert Taylor and Michael H. Ossipov

J Clin Pharm Ther, 2019, 44, 125
DOI: 10.1111/jcpt.12758

Synthesis and in vitro anticancer activities of substituted N -(4′-nitrophenyl)- l -prolinamides

Adejoke Osinubi, Josephat Izunobi, Xiaoguang Bao, Olayinka Asekun, Jiehong Kong, Chunshan Gui and Oluwole Familoni

R. Soc. Open Sci., 2020, 7
DOI: 10.1098/rsos.200906

Structural Characterization of i‐Motif Structure in the Human Acetyl‐CoA Carboxylase 1 Gene Promoters and Their Role in the Regulation of Gene Expression

Mangesh H. Kaulage, Santanu Bhattacharya and K. Muniyappa

ChemBioChem, 2018, 19, 1078
DOI: 10.1002/cbic.201800021

1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships

Zhi Xu, Shi-Jia Zhao and Yi Liu

European Journal of Medicinal Chemistry, 2019, 183, 111700
DOI: 10.1016/j.ejmech.2019.111700

Probing the Competition between Duplex, G‐Quadruplex and i‐Motif Structures of the Oncogenic c‐Myc DNA Promoter Region

Akanksha Pandey, Sarupa Roy and Seergazhi G. Srivatsan

Chemistry An Asian Journal, 2023, 18
DOI: 10.1002/asia.202300510

Novel triazole and morpholine substituted bisnaphthalimide: Synthesis, photophysical and G-quadruplex binding properties

Zhize Ou, Zhiyuan Li, Yunyan Gao, Wenli Xing, Hongdan Jia, Huan Zhang and Na Yi

Journal of Molecular Structure, 2019, 1185, 27
DOI: 10.1016/j.molstruc.2019.02.073

Switching off cancer – An overview of G-quadruplex and i-motif functional role in oncogene expression

Carolina Roxo and Anna Pasternak

Bioorganic & Medicinal Chemistry Letters, 2025, 116, 130038
DOI: 10.1016/j.bmcl.2024.130038

Deciphering the Nanoconfinement Effect on the Folding Pathway of c-MYC Promoter-Based Intercalated-Motif DNA by Single-Molecule Förster Resonance Energy Transfer

Laxmikanta Khamari and Saptarshi Mukherjee

J. Phys. Chem. Lett., 2022, 13, 8169
DOI: 10.1021/acs.jpclett.2c01893

Major Achievements in the Design of Quadruplex-Interactive Small Molecules

Eduarda Mendes, Israa M. Aljnadi, Bárbara Bahls, Bruno L. Victor and Alexandra Paulo

Pharmaceuticals, 2022, 15, 300
DOI: 10.3390/ph15030300

Advances in i-motif structures: Stability, gene expression, and therapeutic applications

Mengqing Wu, Yang Liu, Xiao Zhu, Xiaoke Zhang, Qinghong Kong, Wei Lu, Xiao Yuan, Yunlai Liu, Yang Liu, Keyu Lu, Yangxue Dai and Bo Zhang

International Journal of Biological Macromolecules, 2025, 311, 143555
DOI: 10.1016/j.ijbiomac.2025.143555

Mechanism of unfolding and relative stabilities of G-quadruplex and I-motif noncanonical DNA structures analyzed in biased molecular dynamics simulations

Tomasz Panczyk, Patrycja Wojton and Pawel Wolski

Biophysical Chemistry, 2019, 250, 106173
DOI: 10.1016/j.bpc.2019.106173

Chemical Regulation of DNA i‐Motifs for Nanobiotechnology and Therapeutics

Manish Debnath, Khushnood Fatma and Jyotirmayee Dash

Angew Chem Int Ed, 2019, 58, 2942
DOI: 10.1002/anie.201813288

Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation

Sabrina Pia Nuccio, Enrico Cadoni, Roxani Nikoloudaki, Silvia Galli, An-Jie Ler, Claudia Sanchez-Cabanillas, Thomas E. Maher, Ella Fan, Dilek Guneri, Gem Flint, Minghui Zhu, Ling Sum Liu, Christopher R. Fullenkamp, Zoë Waller, Luca Magnani, John S. Schneekloth and Marco Di Antonio

Nat Commun, 2025, 17
DOI: 10.1038/s41467-025-67074-z

Regulatory role of Non-canonical DNA Polymorphisms in human genome and their relevance in Cancer

Nirali Pandya, Sonali R. Bhagwat and Amit Kumar

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2021, 1876, 188594
DOI: 10.1016/j.bbcan.2021.188594